Professor CHAN Man Lok, Andrew
Director, School of Biomedical Sciences
CUHK Employment
- Director and Professor, School of Biomedical Sciences
- Associate Director, Brain and Mind Institute
- Fellow, CW Chu College
Expertise
- Cancer Biology
Education & Qualifications
BSc in Biochemistry (Lancaster University), Ph.D. in Molecular Biology (University of London)
Research Interests
- Cancer cell signaling
- Genetics of Autism and Alzheimer’s Disease
- Mouse models of human diseases
Additional Information
Award & Honour
- Fogarty International Fellow, National Institutes of Health, United States, 1989-1992
- Irma T. Hirschl Career Scientist Award, Mount Sinai School of Medicine, United States, 1996-2001
- Visiting Professor, Southwest Medical University, China
Professional Service
- Grant Reviewer, Department of Defence, United States
- Grant Reviewer, PO1, SRRB, SBIT/STTR, RC2, TPM Study Sections, National Institutes of Health, United States
- Member, Grant Review Board, Health and Medical Research Fund, Food and Health Bureau, Hong Kong
- Regional Editor, Recent Patents on Anti-Cancer Drug Discovery
- Member, Editorial Board, Cancer Letters
Academic Engagement in CUHK
- Chief, Cancer Biology & Experimental Therapeutics Thematic Research Programme
- Chairman, External Links and Exchange Committee, CW Chu College
- Member, Management Board of the Institute of Biotechnology
- Member, Committee on BSc in Biomedical Sciences Programme
Selected Publications
- Wong CW, Or PMY, Wang Y, Li L, Li J, Yan M, Cao Y, Luk HM, Tong TMF, Leslie NR, Lo IFM, Choy RKW, Chan AM. Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays and macrocephaly. Autism Research, 11, 1098-1109. 2018.
- Yan M, Wang Y, Wong CW, Or PM, Wong KL, Li L, Many AM, Guan H, Khoo US, Chan AM. PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model. Cancer Lett, 430, 67-78. 2018.
- Knafo S, Sanchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordonez-Guiterrez L, Wandosell F, Vina J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA. PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nature Neuroscience, 19, 443-45 2016.
- Singh, G., Hashimoto, D., Yan, X., Helft, J., Ma, G., Qiao, R.F., Kennedy, C.R., Chen, S.-H., Merad, M., & Chan, A.M. (2012). R-Ras is required for Murine Dendritic cell maturation and CD4+ T-cell priming. Blood, 119, 1693-1701.
- Odriozola, L., Singh, G., Hoang, T., & Chan, A.M. (2007). Regulation of PTEN Activity by its Carboxyl-terminal Autoinhibitory domain. J Biol Chem, 282, 23306-2331
- Goutham N., Heath, K.E., Reeves, H.L., Li, D., Giono, L.E., Kimmelman, A.C., Glucksman, M.J., Narla, J., Eng, F.J., Chan, A.M., Ferrari, A.C., Martignetti, J.A., & Friedman, S.L. (2001). KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science, 294, 2563-256
- Tolkacehva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A.C., & Chan, A.M. (2001). Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at Threonine codon 382 & 383. Cancer Research, 61, 4985-4989.
- Clark, J., Rocques, P.J., Crew, A.J., Gill, S., Shipley, J., Chan, A.M., Gusterson, B.A., & Cooper, C.S. (1994). Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics, 7, 502-50
- Chan, A.M., Miki, T., Meyers, K.A., & Aaronson, S.A. (1994). A new human oncogene of the ras superfamily unmasked by expression cDNA cloning. Proc Natl Acad Sci USA, 91, 7558-7562.
- Bottaro, D.P., Rubin, J.S., Falletto, D.L., Chan, A.M., Kmiecik, T.E., Vande Woude, G.F., & Aaronson, S.A. (1991). Identification of the HGF receptor as the c-met protooncogene product. Science, 251, 802-804.