中大職務
- 醫學院副院長 (內地事務)
- 卓敏生物醫學研究教授，內科及藥物治療學系
- 李嘉誠健康科學研究所副所長
- 和聲書院院務委員
專業範疇
免疫病理學
分子病理學
教育及資歷
MBBS, MMed (SYSU); PhD (Monash)
專注研究
- 生長轉化因子－β信號傳導通路與腎臟和心血管疾病
- 生長轉化因子－β信號傳導通路與腫瘤微環境
更多資訊
獎項及榮譽
- 國家科學技術進步獎二等獎, 2016
- 中華醫學科技一等獎, 2015
- 澳大利亞西澳大學 Rain 訪問教授, 2014
- 高等學校科學研究優秀成果獎自然科學二等獎, 2014
- 香港腎臟病學會陳煥章紀念獎, 2010
專業服務
- 中國腎臟病生理學會副主任
- Clinical Experimental Pharmacology and Physiology 編輯
- Frontier in Physiology 副編輯
- Journal of Cellular and Molecular Medicine 副編輯
- Journal of the American Society of Nephrology 編輯委員會會員
- Molecular Therapy 編輯委員會會員
- International Journal of Biological Sciences 編輯委員會會員
- Scientific Reports 編輯委員會會員
- Kidney Diseases 編輯委員會會員
中大教學職務
- 動物倫理委員會主席
- 和聲書院國際學生交流計畫委員會主席
部分論文 (只有英文版本)
(https://scholar.google.com/citations?hl=en&view=&user=6cC_60cAAAAJ)
- Tang PM, Zhou S, Li CJ, Liao J, Xiao J, Wang QM, Lian GY, Li J, Huang XR, To KF, Ng CF, Chong CC, Ma RC, Lee TL, Lan HY. The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int.93(1):173-187, 2018.
- Sun SF, Tang PMK, Feng M, Xiao J, Huang XR, Li P, Ma RCW, Lan HY. Novel lncRNA Erbb4-IR Promotes Diabetic Kidney Injury in db/db Mice by Targeting miR-29b. Diabetes. 67(4):731-744, 2018.
- Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nat Commun.8:14677, 2017.
- Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, To KF, Nikolic-Paterson DJ, Lan HY, Chen JH. Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury. J Am Soc Nephrol. 28(7):2053-2067, 2017.
- Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Lan HY. Disrupted Smad4 impairs TGF-/Smad3 and Smad7 transcriptional regulation in renal inflammation and fibrosis in vivo and in vitro. Kidney Int 81:266-79, 2012.
- Zhong X, Chung AC, Chen HY, Meng XM, Lan HY. Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis. J Am Soc Nephrol. 22:1668-81, 2011.
- Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY. TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. J Am Soc Nephrol. 22:1462-1474, 2011.
- Chen H, Huang XR, Wang W, Li J, Heuchel RL, Chung AC, Lan HY. The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential. Diabetes. 60:590-601, 2011.
- Meng X, Huang XR, Chung ACK, Shao X, Igarashi P, Ju W, Berttinger E, Lan HY: Smad2 protects against TGF-/Smad3-mediated extracellular matrix production and renal fibrosis in vitro and in vivo. J Am Soc Nephrol 21:1477-87, 2010.
- Chung AC, Huang XR, Meng X, Lan HY. miR-192 Mediates TGF-{beta}/Smad3-Driven Renal Fibrosis. J Am Soc Nephrol. 21: 1317-1325,2010.
- Koka V, Wang W , Huang XR , Kim-Mitsuyama S, Truong LD, Lan HY: Advanced Glycation End Products Activate a Chymase-Dependent Angiotensin II Generating Pathway in Diabetic Complications. Circulation 113(10):1353-60, 2006.
- Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY: Essential role of Smad3 in Angiotensin II-Induced Vascular Sclerosis. Circ. Res. 98:1032-9, 2006.