Dr DING Xiaofan John    
丁肖凡

Biography

Xiaofan Ding obtained his PhD degree in the Division of Life Science at HKUST in 2014 and pursued his post-doctoral training in CUHK (2014-2019). Xiaofan Ding’s research focuses on two fundamental areas in HCC: (1) Intra- and inter-tumor (epi)genetic heterogeneity, (2) cancer epigenetics and functional genomics. He managed to employ a variety of computational methods to integrate information from multiple sources, such as transcriptome, cancer genomics and epigenetics, to generate molecular alteration landscape and identify key regulatory elements in HCC.

Research Interests

• Cancer genomics and epigenetics
• Intra- and inter-tumor heterogeneity
• Epigenetic regulation

Selected Publications

1. Ding XF, He M, Chan AW, Song QX, Sze SC, Chen H, Man MK, Man K, Chan S, Lai P, Wang X, Wong N*. Genomic and epigenomic features of primary and recurrent hepatocellular carcinomas. Gastroenterology 2019; 157:1630-1645.
2. Wong AM, Ding XF, Wong AM, Chan AW, Song QX, Kwong J, Xu M, You W, Man MKH, He M, Chen J, Zhang Z, Lau C, Yu AC, Wei Y, Yuan Y, Lai PBS, Zhao J, Man K, Yu J, Kahn M, Wong N*. Molecular Distinctions of Non-Alcoholic Fatty Liver Disease-associated Liver Cancer accentuate β-Catenin-mediated Immune Evasion. (Journal of Hepatology 2021) (under review) (Co-first).
3. Ding XF, Tsang SY, Ng SK, Xue H*. Application of Machine Learning to Development of Copy Number Variation-based Prediction of Cancer Risk. Genomics Insights 2014; 7:1-11.