Dr. Allen T C LEE,
Assistant Professor (Clinical)

• Honorary Associate Consultant, New Territories East Cluster, Hospital Authority
• Vice President, The Chinese Dementia Research Association
• Council member, Hong Kong College of Psychiatrists
• Education Committee member, Hong Kong College of Psychiatrists
• Publications Committee member, Hong Kong College of Psychiatrists
• Editorial Board member, East Asian Archives of Psychiatry (EAAP)

• Distinguished Young Fellow, awarded by the Hong Kong Academy of Medicine on 16 November 2017

• Epidemiology, prevention, early detection, and intervention for neurocognitive disorders
• Determinants of healthy aging
• Associations among physical, mental, and cognitive health

1. Can increasing participation in habitual intellectual activities enhance functional connectivity of default mode network in community-living Chinese adults with subjective cognitive decline? A randomized controlled trial.
   (Funded by Early Career Scheme, RGC 2019/2020. Capacity: PI. Ref. number: 24114519. Funding: $1,190,840. Study duration: 1/1/2020-31/12/2021)
2. Can whole-body vibration treatment optimize cognitive function in older adults who have sarcopenia and are at risk of dementia? A randomized controlled trial
   (Funded by HMRF. Capacity: PI. Reference number: 08190476. Funding: $1,386,977. Study duration: 17/12/2021-16/12/2023)
3. Structured frontal lobe based cognitive stimulation to older adults with subjective cognitive decline and comorbid depressive symptoms
   (Funded by CUHK Direct Grant for Research 2018/2019. Reference number: 2018.076. Capacity: PI. Funding: $149,947. Study duration: 30/6/2019-29/6/2022)
4. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
   (Funded by HMRF Commissioned Study 2018. Ref. number: CFS-CUHK3. Capacity: Co-PI. PI: Linda Lam, Dept of Psychiatry, CUHK. Funding: $7,492,300. Study duration: 1/7/2019-30/6/2022)
5. Small Data Learning for Alzheimer’s Disease: From Digital Biomarker to Early Detection and Intervention
   (Funded by CRF. Capacity: Co-PI. Reference number: C4034-21GF. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: $8,230,720. Study duration: 1/1/2022-31/12/2024.)
6. Machine learning technologies for advancing digital biomarkers for Alzheimer’s Disease
   (Funded by the Alzheimer’s Drug Discovery Foundation. Capacity: Co-PI. Reference number: GDADB-201906-2019049. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: USD$641,204. Study duration: 1/7/2020-30/6/2023)
7. A 9-year follow-up of the Hong Kong Mental Morbidity Survey (HKMMS) on Chinese adults with depressive and anxiety symptoms.
   (Funded by HMRF Commissioned Study 2018. Ref number: CFS-CUHK4.Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $7,767,730. Study duration:1/7/2019-31/12/2023)
8. The Hong Kong Mental Morbidity Survey for Older People – MMSOP
   (Funded by HMRF Commissioned Study 2018. Ref. number: MHS-P1(Part 3)-CUHK. Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $14,996,125. Study duration: 1/1/2019-31/12/2022)
9. Combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment: a randomized controlled trial
   (Funded by HMRF 2017. Capacity: Co-I. Reference number: 16170421. PI: Professor Samuel Wong, School of Public Health and Primary Care, CUHK. Funding: $1,499,589. Study duration: 16/9/2019-15/3/2024)
10. Mortality among older persons with schizophrenia in Hong Kong
    (Funded by HMRF. Capacity: Co-I. Reference number: 18192331. PI: Dr. WC Chan, Department of Psychiatry, HKU. Funding: $732,624. Study duration: 3/1/2022-2/1/2024)
11. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly
    (Funded by HMRF. Capacity: Co-I. Reference number: 09200246. PI: Dr. SL Ma, Department of Psychiatry, CUHK. Funding: $1,446,240. Study duration: 1/4/2022-31/3/2025)
12. Novel MRI-based machine learning tool to detect mild cognitive impairment associated with Alzheimer’s disease
    (Funded by HMRF. Capacity: Co-I. Reference number: 08190666. PI: Dr. Ho Ko, CUHK. Funding: $911,140. Study duration: 5/2/2022-4/2/2024)
13. The role of big data in addressing the determinants of non-communicable diseases in the ageing era – collaboration between CUHK and Worldwide Universities Network (WUN) partners
    https://wun.ac.uk/wun/research/view/the-role-of-big-data-in-addressing-the-determinants-of-non-communicable-diseases-in-the-ageing-era

    http://www.oal.cuhk.edu.hk/201909-41-cuhk-wun/

1. Lai VKY, Fung AWT, Lam LCW, Lee ATC.
   Is sleep quality a potential predictor of neurocognitive disorders? A 6-year follow-up study in Chinese older adults.
   International Journal of Geriatric Psychiatry. 2022 Aug;37(8).   
2. Lee ATC, Chiu HFK, Peisah C.
   Clinical considerations when using assessment tools to identify depression in older adults with mild cognitive impairment.
   International Psychogeriatrics. 2022 May;34(5):413-416.
3. Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Late-life longitudinal blood pressure trajectories as predictor of dementia.
   Scientific Reports. 2022 Jan 31;12(1):1630.
4. Lee ATC, Cheng GWH, Lin C, Wong BHC, Lam LCW.
   Do people with mental health problems have lower adherence to precautionary measures in COVID-19 pandemic? A cross-sectional observational study in Hong Kong.
   BMJ Open. 2021 Aug 12;11(8):e046658.
5. Lam LCW, Lee ATC.
   Is cognitive screening useful for long-term prediction of incident dementia?
   The Lancet Healthy Longevity. 2021 July 1;2(7):e387-e388.
6. Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL.
   The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.
   Ophthalmology. 2021 Jul;128(7):981-992.
7. Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee ATC, Kwok C, Lai M, Mok V, Lau A.
   Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.
   Brain Communications. 2021 June;3(3):fcab124.
8. Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Risk of incident dementia varies with different onset and courses of depression.
   Journal of Affective Disorders. 2021 Mar 1;282:915-920.
9. Chan WC, Lee ATC, Lam LCW.
   Exercise for the prevention and treatment of neurocognitive disorders: new evidence and clinical recommendations.
   Current Opinion in Psychiatry. 2021 Mar 1;34(2):136-141.
10. Lee ATC, Mo FYM, Lam LCW.
    Higher psychogeriatric admissions in COVID-19 than in severe acute respiratory syndrome.
    International Journal of Geriatric Psychiatry. 2020 Dec;35(12):1449-1457.

Guest Editor for:

• Age and Ageing
• Alzheimer’s & Dementia
• Alzheimer’s & Dementia: Translational Research & Clinical Interventions
• Behavioral Sleep Medicine
• BJPsych Open
• BMC Geriatrics
• BMJ Open
• Frontiers in Dementia
• Frontiers in Psychiatry
• International Psychogeriatrics
• Stress & Health

Supervised over 10 Master and PhD students at CUHK

Serving as a mentor for GPS Medical Students at CUHK