Dr. KO Ho, Owen
Assistant Dean (Research)
Assistant Professor, Department of Medicine and Therapeutics
CUHK Employment
Assistant Dean (Research), Faculty of Medicine
Assistant Professor, Department of Medicine and Therapeutics, School of Biomedical Science
Assistant Professor (by courtesy), Department of Psychiatry
Associate Director, Margaret K. L Cheung Research Centre for Management of Parkinsonism
Principal Investigator, Li Ka Shing Institute of Health Sciences
Principal Investigator, Gerald Choa Neuroscience Centre
Expertise
- Neuroscience
Education & Qualifications
BMedSc (CUHK), MBChB (CUHK), PhD (UCL)
Research Interests
- Glial and vascular cell dysfunction in neurodegenerative disorders
- Neural circuits
- Development of imaging tools
Additional Information
Award and Honour
- Awardee, Excellent Young Scientists Fund (Hong Kong and Macau), The National Natural Science Foundation of China, 2021
- Croucher Innovation Award, The Croucher Foundation, 2020
- Finalist, Eppendorf and Science Prize for Neurobiology, 2014
Selected Publications
Researcher ID: https://publons.com/researcher/2254191/ho-ko/
- Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau CN, Chan CCY, Chan DCW, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H. Antibody stabilization for thermally accelerated deep immunostaining. Nature Methods. 2022 (accepted)
- Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Lai HM, Mok VCT, Ko H. Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner. Communications Biology. 2021 Jun 2;4(1):656.
- Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H. Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nature Communications. 2020 Sep 4;11(1):4413.
- Li Q*, Ko H*, Qian ZM, Yan LYC, Chan DCW, Arbuthnott GW, Ke Y, Yung WH. Refinement of learned skilled movement representation in motor cortex deep output layer. Nature Communications. 2017 Jun 9; 8:15834.
- Ko H. Runner-up, Eppendorf and Science Prize for Neurobiology 2014. Functional organization of synaptic connectivity in the neocortex. Science. 2014 Oct 31; 346(6209):555.
- Ko H, Mrsic-Flogel TD, Hofer SB. Emergence of feature-specific connectivity in cortical microcircuits in the absence of visual experience. Journal of Neuroscience. 2014 July 16:34(29):9812-9816.
- Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD. The emergence of functional microcircuits in visual cortex. Nature. 2013 Apr 4;496(7443):96-100.
- Hofer SB*, Ko H*, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD. Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex. Nature Neuroscience. 2011 Jul 17;14(8):1045-52.
- Ko H, Hofer SB, Pichler B, Buchanan KA, Sjöström PJ, Mrsic-Flogel TD. Functional specificity of local synaptic connections in neocortical networks. Nature. 2011 May 5;473(7345):87-91.