Research Assistant Professor
Room 245 Science Centre
(852) 3943 1326
Education
| 2015-2020 | Ph.D. | City University of Hong Kong |
| 2009-2012 | B.Sc. | The University of Hong Kong |
Position
| Since 2021 | Research Assistant Professor, The Chinese University of Hong Kong |
Research Interests
| My research will focus on |
| 1. functionalizing biocompatible nanomaterials with theranostic agents for diagnosis and therapy |
| 2. developing nanodevices for bioanalytical, computing or other biological applications |
Honours and Awards
| 2019 | Best Poster Award (Analytical & Environmental Chemistry), 2019, The 26th Symposium on Chemistry Postgraduate Research in Hong Kong |
| 2017-2019 | Outstanding Academic Performance Award for Research Degree Students (local UGC-funded students), 2017-2019, SGS of City University of Hong Kong |
Representative Publications
| 1. | Tam, D. Y.,‡ Ho, J. W-T.,‡ Chan, M. S., Lau, C. H., Chang, T. J. H., Leung, H. M., Liu, L. S., Wang ,F., Chan, L. L. H., Tin, C., & Lo, P. K., Penetrating the Blood–Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy, 20 May 2020 In: ACS Applied Materials & Interfaces. 12, 26, p. 28928-28940 |
| 2. | Tam, D. Y., Zhuang, X., Wong, S. W. & Lo, P. K., Photoresponsive Self-Assembled DNA Nanomaterials: Design, Working Principles, and Applications, 26 Jun 2019, In: Small. 15, 26, 1805481. |
| 3. | Tam, D. Y., Leung, H. M., Chan, M. S. & Lo, P. K., G-Quadruplex-Mediated Molecular Switching of Self-Assembled 3D DNA Nanocages, 1 Oct 2017, In: ChemNanoMat. 3, 10, p. 750-754 |
| 4. | Tam, D. Y., Dai, Z., Chan, M. S., Liu, L. S., Cheung, M. C., Bolze, F., Tin, C. & Lo, P. K., A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations, 4 Jan 2016, In: Angewandte Chemie – International Edition. 55, 1, p. 164-168 |
| 5. | Tam, D. Y. & Lo, P. K., Multifunctional DNA nanomaterials for biomedical applications, 19 Mar 2015, In: Journal of Nanomaterials. 2015, 765492 |
| 6. | Wang, F., Liu, L.S., Li, P., Leung, H.M, Tam, D.Y. & Lo, P. K., Biologically stable threose nucleic acid-based probes for real-time microRNA detection and imaging in living cells, 8 Mar 2022, In: Molecular Therapy – Nucleic Acids. 27, 787-796. |
| 7. | Leung, H. M., Lau, C. H., Ho, J. W-T., Chan, M. S., Chang, T. J. H., Law, L. H., Wang, F., Tam, D. Y., Liu, L. S., Chan, K. W. Y., Tin, C., & Lo, P. K. Targeted brain tumor imaging by using discrete biopolymer-coated nanodiamonds across the blood-brain barrier, 7 Feb 2021 In: Nanoscale. 13, 5, p. 3184-3193. |
| 8. | Wang, F., Liu, L. S., Lau, C. H., Han Chang, T. J., Tam, D. Y., Leung, H. M., Tin, C. & Lo, P. K, Synthetic α-L-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy, 23 Oct 2019, In: ACS Applied Materials and Interfaces. 11, 42, p. 38510−38518 |
| 9. | Liu, C., Zhou, B., Geng, Y., Tam, D. Y., Feng, R., Miao, H., Xu, N., Shi, X., You, Y., Hong, Y., Zhong, B., Lo, P.K., Kuryavyi, V. & Zhu, G., A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution, 7 Jan 2019, In: Chemical Science. 10, 1, p. 218-226 |
| 10. | Liu, L. S., Leung, H. M., Tam, D. Y., Lo, T. W., Wong, S. W. & Lo, P. K., α- L -Threose Nucleic Acids as Biocompatible Antisense Oligonucleotides for Suppressing Gene Expression in Living Cells, 21 Mar 2018, In: ACS Applied Materials and Interfaces. 10, 11, p. 9736-9743 |
| 11. | Wang, Z., Tam, D. Y., Susha, A. S., Chan, M. S., Kershaw, S. V., Lo, P. K. & Rogach, A. L., Aggregation-free DNA nanocage/Quantum Dot complexes based on electrostatic adsorption, 20 Apr 2016, In: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 495, p. 62-67 |
| 12. | Chan, M. S., Tam, D. Y., Dai, Z., Liu, L. S., Ho, J. W., Chan, M. L., Xu, D., Wong, M.S., Tin, C. & Lo, P.K., Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers, 10 Feb 2016, In: Small. 12, 6, p. 770-781 |
| 13. | Dai, Z., Tam, D. Y., Xu, H., Chan, M. S., Liu, L. S., Bolze, F., Sun, X. H. & Lo, P. K., Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation, 2 Sep 2015, In: Small. 11, 33, p. 4090-4096 |
| 14. | Chan, M. S., Xu, D., Guo, L., Tam, D. Y., Liu, L. S., Chen, Y., Wong, M. S. & Lo, P. K., Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection, 14 Jul 2015, In: Organic and Biomolecular Chemistry. 13, 26, p. 7307-7312 |
| 15. | Guo, L., Chan, M. S., Xu, D., Tam, D. Y., Bolze, F., Lo, P. K. & Wong, M. S., Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging 15 May 2015, In: ACS Chemical Biology. 10, 5, p. 1171-1175 |
Major Grant
CUHK, Direct grant (2021/2022). G-quadruplex-based horseradish peroxidase mimicking DNAzyme activating chemiluminescence-mediated photodynamic therapy, PI, 2021-2022
Patents
| LO, P. K. P., LIU, L. S., & TAM, D. Y. (Accepted/In press). Methods And Compositions for Synthesis of Two-photon Cleavable Phosphoramidite Molecules for Oligonucleotide Conjugation. |