Department of Anaesthesia and Intensive Care CUHK

Prof. Lowell LING
LMCHK, MBBS (UK), MPhil (Cantab), MRCP (UK), FHKCA (IC), FHKAM (Anaes), FCICM

Assistant Professor
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Assistant Professor
Intensive Care Unit,
Prince of Wales Hospital

Research Interests
My research interests are in sepsis, organ dysfunction and critical care. I am currently researching on epidemiology of sepsis in Hong Kong and using genomic approaches to understand sepsis. I am a steering committee member of Asian Pacific Sepsis Alliance and serve on the editorial board of Journal of Intensive Care.

Publications:

For a list of my publications and citations please refer to:
https://scholar.google.com/citations?user=1S6mAacAAAAJ&hl=en
ORCID: 0000-0001-6639-7344

2021

Ling L*, Ho CM, Ng PY, Chan KCK, Shum HP, Chan CY, Yeung AWT, Wong WT, Au SY, Leung KHA, Chan JKH, Ching CK, Tam OY, Tsang HH, Liong T, Law KI, Dharmangadan M, So D, Chow FL, Chan WM, Lam KN, Chan KM, Mok OF, To MY, Yau SY, Chan C, Lei E, Joynt GM. Characteristics and outcomes of patients admitted to adult intensive care units in Hong Kong: a population retrospective cohort study from 2008 to 2018. J Intensive Care. 2021;9(1):2.
https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-020-00513-9
Yeoh YK, Zuo T, Lui GC, Zhang F, Liu Q, Li AY, Chung AC, Cheung CP, Tso EY, Fung KS, Chan V, Ling L, Joynt G, Hui DS, Chow KM, Ng SSS, Li TC, Ng RW, Yip TC, Wong GL, Chan FK, Wong CK, Chan PK, Ng SC. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut. 2021. doi:10.1136/gutjnl-2020-323020
https://gut.bmj.com/content/70/4/698
Ling L*, Joynt GM, Lipman J. A narrative review on antimicrobial therapy in septic shock: updates and controversies. Curr Opin Anaesthesiol. 2021;34(2):92-98.
https://journals.lww.com/co-anesthesiology/Fulltext/2021/04000/A_narrative_review_on_antimicrobial_therapy_in.6.aspx
Kwak GH, Ling L*, Hui P. Deep reinforcement learning approaches for global public health strategies for COVID-19 pandemic. PLoS One. 2021;16(5):e0251550.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251550
Zuo T, Liu Q, Zhang F, Yeoh YK, Wan Y, Zhan H, Lui GCY, Chen Z, Li AYL, Cheung CP, Chen N, Lv W, Ng RWY, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chan FKL, Chan PKS, Ng SC. Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity. Microbiome. 2021;9(1):91.
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01008-x

2020

Kwak GH, Ling L*, Hui P. Predicting the Need for Vasopressors in the Intensive Care Unit Using an Attention Based Deep Learning Model. Shock. 2020. https://journals.lww.com/shockjournal/Abstract/9000/Predicting_the_Need_for_Vasopressors_in_the.97350.aspx

Siu BMK, Kwak GH, Ling L*, Hui P. Predicting the need for intubation in the first 24 h after critical care admission using machine learning approaches. Sci Rep. 2020;10(1):20931.
https://www.nature.com/articles/s41598-020-77893-3

Phua J, Weng L, Ling L, Egi M, Lim C-M, Divatia JV, Shrestha BR, Arabi YM, Ng J, Gomersall CD, Nishimura M, Koh Y, Du B. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506-517.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30161-2/fulltext

Ling L*, Joynt GM, Lipman J, Constantin JM, Joannes-Boyau O. COVID-19: a critical care perspective informed by lessons learnt from other viral epidemics. Anaesth Crit Care Pain Med. 2020;39(2):163-166.
https://www.sciencedirect.com/science/article/pii/S2352556820300291?via%3Dihub

Ling L*, So C, Shum HP, Chan PKS, Lai CKC, Kandamby DH, Ho E, So D, Yan WW, Lui G, Leung WS, Chan MC, Gomersall CD. Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study. Crit Care Resusc. 2020;22(2):119-125.
https://ccr.cicm.org.au/supplementary-june-2020/original-article-covid19

Phua J, Faruq MO, Kulkarni AP, Redjeki IS, Detleuxay K, Mendsaikhan N, Sann KK, Shrestha BR, Hashmi M, Palo JEM, Haniffa R, Wang C, Hashemian SMR, Konkayev A, Mat Nor MB, Patjanasoontorn B, Nafees KMK, Ling L, Nishimura M, Al Bahrani MJ, Arabi YM, Lim CM, Fang WF. Critical Care Bed Capacity in Asian Countries and Regions. Crit Care Med. 2020;48(5):654-662.
https://journals.lww.com/ccmjournal/Abstract/onlinefirst/Critical_Care_Bed_Capacity_in_Asian_Countries_and.95746.aspx

Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK. Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care. 2020;24(1):47.
https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-2754-5
Ling L*, Wong WT, Wan WTP, Choi G, Joynt GM. Infection control in non-clinical areas during COVID-19 pandemic. Anaesthesia. 2020;75(7):962-963.
https://onlinelibrary.wiley.com/doi/abs/10.1111/anae.15075
Lui G, Ling L, Lai CK, Tso EY, Fung KS, Chan V, Ho TH, Luk F, Chen Z, Ng JK, Chow KM, Cheng PK, Chan RC, Tsang DN, Gomersall CD, Hui DS, Chan PK. Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19. J Infect. 2020;81(2):318-356.
https://www.sciencedirect.com/science/article/pii/S0163445320302255?via%3Dihub
Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, Wan Y, Chung A, Cheung CP, Chen N, Lai CKC, Chen Z, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chan FKL, Chan PKS, Ng SC. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. Gastroenterology. 2020.
https://www.sciencedirect.com/science/article/pii/S0016508520347016?dgcid=rss_sd_all
Lai CKC, Chen Z, Lui G, Ling L, Li T, Wong MCS, Ng RWY, Tso EYK, Ho T, Fung KSC, Ng ST, Wong BKC, Boon SS, Hui DSC, Chan PKS. Prospective study comparing deep-throat saliva with other respiratory tract specimens in the diagnosis of novel coronavirus disease (COVID-19). J Infect Dis. 2020.
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiaa487/5879767
Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L*. A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC Infect Dis. 2020;20(1):652.
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05330-x
Ling L*, Gomersall CD. Potential Aerosol Generation by Bronchoscopy And Intubation: Another Piece in the Puzzle. Chest. 2020;158(6):2251-2252. https://journal.chestnet.org/article/S0012-3692(20)34333-6/fulltext
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira A, Renieri A, Gen OI, Investigators I, Initiative C-HG, andMe I, Investigators B, Gen CI, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Genetic mechanisms of critical illness in Covid-19. Nature. 2020.
https://www.nature.com/articles/s41586-020-03065-y

Before 2019

Ng WT, Ling L, Joynt GM, Chan KM. An audit of mortality by using ECMO specific scores and APACHE II scoring system in patients receiving extracorporeal membrane oxygenation in a tertiary intensive care unit in Hong Kong. J Thorac Dis. 2019;11(2):445-455.
http://jtd.amegroups.com/article/view/26528/20042

Leung CCH, Joynt GM, Gomersall CD, Wong WT, Lee A, Ling L, Chan PKS, Lui PCW, Tsoi PCY, Ling CM, Hui M. Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial. J Hosp Infect. 2019;101(1):84-87.
https://www.sciencedirect.com/science/article/pii/S0195670118305425

Ling L, Chan KM. Weaning adult patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation by pump-controlled retrograde trial off. Perfusion. 2018;33(5):339-345.
Joynt GM, Wong WT, Ling L, Lee A. Medical students and professionalism - Do the hidden curriculum and current role models fail our future doctors? Med Teach. 2018;40(4):395-399.

Tse AHW, Ling L, Lee A, Joynt GM. Altered Pharmacokinetics in Prolonged Infusions of Sedatives and Analgesics Among Adult Critically Ill Patients: A Systematic Review. Clin Ther. 2018;40(9):1598-1615.e1592.

Tse AH, Ling L, Joynt GM, Lee A. Prolonged infusion of sedatives and analgesics in adult intensive care patients: A systematic review of pharmacokinetic data reporting and quality of evidence. Pharmacol Res. 2017;117:156-165.

Ling L, Gomersall CD, Samy W, Joynt GM, Leung CCh, Wong WT, Lee A. The Effect of a Freely Available Flipped Classroom Course on Health Care Worker Patient Safety Culture: A Prospective Controlled Study. J Med Internet Res. 2016;18(7):e180.

Ling L, Maguire JJ, Davenport AP. Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. Br J Pharmacol. 2013;168(2):283-295.

Ling L, Kuc RE, Maguire JJ, Davie NJ, Webb DJ, Gibbs P, Alexander GJ, Davenport AP. Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice. Life Sci. 2012;91(13-14):716-722.

Mahony O, Tsigkou O, Ionescu C, Minelli C, Ling L, Hanly R, Smith ME, Stevens MM, Jones JR. Silica-Gelatin Hybrids with Tailorable Degradation and Mechanical Properties for Tissue Regeneration. Advanced Functional Materials. 2010;20(22):3835-3845.