Academic Publications in Gynaecological Endoscopy
The Gynaecological Endoscopy Team has both clinical and basic research interests not only in Gynecological Endoscopic surgery, but also in endometriosis, uterine fibroids as well as postmenopausal bleeding. The following are the highlights of publications.
Endometriosis
Current hormonal and surgical treatment for endometriosis still cannot avoid undesired endocrine side effects and disease recurrence. We are the first group studying therapeutic effects of green tea on endometriosis (Xu et al Hum Reprod 2009). We showed a green tea polyphenol, epigallocatchin-3-gallate (EGCG), as a potent anti-angiogenesis agent for endometriosis (Xu et al Fertil Steril 2011, Xu et al Angiogenesis 2013a). We also had patented an acetylated EGCG as prodrug of EGCG, pro-EGCG, and successfully achieved higher bioavailability and better inhibition in angiogenesis and growth of endometriosis (Wang et al Angiogenesis 2013b).
Postmenopausal Bleeding
Endometrial cancer is currently the most common malignancy of female genital tract in Hong Kong, up to 90 % of women presenting as postmenopausal bleeding (PMB). We set up One- Stop PMB Clinic since 2002 aiming to streamline the management of PMB women. We found the E. coli, B. fragilis, and Enterococcus are the commonest microorganisms isolated in PMB women with uterine collection ( Yeung et al 2014 ). From our study ( n=4383 ), the sensitivity on detecting endometrial malignancy using endometrial thickness 3-, 4-, 5-mm cut-offs were 97%, 94.1% and 93.5% respectively . The specificity were 45.3%, 66.8% and 74% respectively (Wong et al BJOG 2016).
Uterine Fibroid
Our studies have found that the transcervical intralesional injection of vasopressin is useful in decrease fluid absorption, blood loss in hysteroscopic myomectomy patients (Wong et al J Laparoendose Adv Surg Tech 2013; Wong et al Obstetrics and Gynecology 2014). Apart from the surgical treatment, we are also liaised with the Department of Imaging and Interventional Radiology to provide alternative treatments to uterine fibroids, like uterine artery embolization, high-intensity focused ultrasound, especially to women failed medical treatment (Leung et al J Ultrasound Med 2014).
The following are selected publications in endometriosis, uterine fibroids and postmenopausal bleeding.
Endometriosis
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Angiogenic vascular endothelial growth factor C is expressed in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis.
Xu H, Zhang T, Man GCW, May KE, Becker CM, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Wong AWY, Wang CC_.
Angiogenesis 2013a;16:541-551. - Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice.
Wang CC_, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, Cheng JTY, Li G, He YX, Qin L, Lau TS, Kwong J, Chan TH
Angiogenesis 2013b;16:59–69. - Green tea epigallocatchin-3-gallate inhibits angiogenesis and suppresses VEGFC/VEGFR2 expression and signaling in experimental endometriosis in vivo.
Xu H, Becker CM, Lui WT, Chu CY, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Man GCW, Wang CC_.
Fertil Steril 2011;96:1021-1028. -
Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model.
Xu H, Lui WT, Chu CY, Ng PS_, Wang CC_, Rogers MS.
Hum Reprod 2009;24(3): 608-618.
Postmenopausal Bleeding
- Epidemiology and spectrum of positive bacteriological culture in intrauterine fluid collected from women with postmenopausal bleeding.
Yeung SW, Cheung CW, Wong ASW, Fan HL, Chan JHY, Sahota DS, Lao TTTH.
Menopause 2014;21(8):794-8 - Reappraisal of endometrial thickness for the detection of endometrial cancer in postmenopausal bleeding: a retrospective cohort study.
Wong ASW, Lao TTH, Cheung CW, Yeung SW, Fan HL, Ng PS_, Yuen PM, Sahota DS.
BJOG 2016; 123(3):439-446
Uterine fibroid
- Transcervical Intralesional Vasopressin Injection in Hysteroscopic Myomectomy-Description of a New Technique.
Wong ASW, Cheung ECW, Leung VKT, Yeung SW, Leung TY, Fung TY
J Laparoendose Adv Surg Tech 2013;23(3): 258 – 262 - Transcervical Intralesional Vasopressin Injection Compared With Placebo in Hysteroscopic Myomectomy: A Randomized Controlled Trial.
Wong ASW, Cheung ECW, Yeung SW, Fan HL, Leung TY, Sahota DS.
Obstetrics Gynecology 2014;124(5):897-903 - Safety and efficacy of sonographically guided high intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol.
Leung JH, Yu SC, Cheung EC, Wong AS, Tong MM, Ho SS, Leung VY, Ahuja AT
J Ultrasound Med. 2014 Oct;33(10):1811-8. doi: 10.7863/ultra.33.10.1811
| 1 | Development and Validation of Prediction Models for Endometrial Cancer in Postmenopausal Bleeding. Wong ASW, Cheung ECW, Fung LWY, Lao TTH, Mol BWJ, Sahota DS Eur J Obstet Gyn R B 2016;203: 220 - 224 |
| 2 | Reappraisal of Endometrial Thickness for the Detection of Endometrial Cancer in Postmenopausal Bleeding: A Retrospective Cohort. Wong ASW, Lao TTH, Cheung ECW, Yeung SW, Fan HL, Ng PS, Yuen PM, Sahota DS BJOG 2016;123(3): 439 - 446 |
| 3 | Transcervical Intralesional Vasopressin Injection Compared with Placebo in Hysteroscopic Myomectomy. Wong ASW, Cheung ECW, Yeung SW, Fan HL, Leung TY, Sahota DS Obstet Gynecol 2014;124(5): 897 - 903 |
| 4 | Transcervical Intralesional Vasopressin Injection in Hysteroscopic Myomectomy-Description of a New Technique. Wong ASW, Cheung ECW, Leung VKT, Yeung SW, Leung TY, Fung TY J Laparoendose Adv Surg Tech 2013;23(3): 258 - 262 |
| 5 | Comparison of the different types of "laparoscopic total hysterectomy". Leung SW, Chan CS, Lo LSF, Pang CP, Pun TC, Yuen PM J Minim Invasive Gynecol 2007;14(1): 91 - 96 |
| 6 | A cost-utility analysis of hysterectomy, endometrial resection and ablation and medical therapy for menorrhagia. You JHS, Sahota DS, Yuen PM Hum Reprod 2006;21(7): 1878 - 1883 |
| 7 | Postablation-tubal sterilization syndrome following thermal balloon endometrial ablation. Leung PL, Yuen PM Acta Obstet Gyn Scan 2006;85(4): 504 - 505 |
| 8 | Isolated vulval varicosity in the non-pregnant state: a case report with review of the treatment options. Leung SW, Leung PL, Yuen PM, Rogers MS Aust NZ J Obstet Gyn 2005;45(3): 254 - 256 |
| 9 | Outcome in laparoscopic management of persistent adnexal mass during the second trimester of pregnancy. Yuen PM, Ng PS, Leung PL, Rogers MS Surg Endosc 2004;18(9): 1354 - 1357 |
| 10 | Comparison of Peritoneal Oxidative Stress During Laparoscopy and laparostomy. De Souza A, Rogers MS, Wang CC, Yuen PM, Ng PS J Am Assoc Gyn Lap 2003;10(1): 65 - 74 |
| 11 | Hysteroscopic appearance of the endometrial cavity following thermal balloon endometrial ablation. Leung PL, Tam WH, Yuen PM Fertil Steril 2003;79(5): 1226 - 1228 |
| 12 | Intrauterine pathology in women with abnormal uterine bleeding taking hormone replacement therapy. Leung PL, Tam WH, Kong GWS, Yuen PM J Am Assoc Gyn Lap 2003;10(2): 260 - 262 |
| 13 | Life-table analysis of the success of thermal balloon endometrial ablation in the treatment of menorrhagia. Lok IH, Leung PL, Ng PS, Yuen PM Fertil Steril 2003;80(5): 1255 - 1259 |
| 14 | Measurement of Trocar Insertion Force Using a Piezoelectric Transducer. Ng PS, Sahota DS, Yuen PM J Am Assoc Gyn Lap 2003;10(4): 534 - 538 |
| 15 | Successful treatment of ruptured interstitial pregnancy with laparoscopic surgery. A report of 2 cases. Chan Louis YS, Yuen PM J Reprod Med 2003;48(7): 569 - 571 |
| 16 | The effect of intra-abdominal pressure on the generation of 8-iso prostaglandin F2α during laparoscopy in rabbits De Souza A, Wang CC, Chu NCY, Lam PM, Rogers MS Hum Reprod 2003;18(10): 2181 - 2188 |
| 17 | Intrauterine Adhesions after Conservative and Surgical Management of Spontaneous Abortion. Tam WH, Lau WC, Cheung LP, Yuen PM, Chung TKH J Am Assoc Gyn Lap 2002;9(2): 182 - 185 |
| 18 | Patient-Controlled Sedation for Outpatient Thermal Balloon Endometrial Ablation. Lok IH, Chan MTV, Tam WH, Leung PL, Yuen PM J Am Assoc Gyn Lap 2002;9(4): 436 - 441 |
| 19 | Randomized double-masked comparison of radially expanding access device and conventional cutting tip trocar in laparoscopy. Yim SF, Yuen PM Obstet Gynecol 2001;97(3): 435 - 438 |
| 20 | Use of diclofenac as an analgesic in outpatient hysteroscopy: a randomized, double-blind, placebo-controlled study. Tam WH, Yuen PM Fertil Steril 2001;76(5): 1070 - 1072 |
| 21 | A randomised double-blind placebo-controlled trial of transcervical intrauterine local anaesthesia in outpatient hysteroscopy. Lau WC, Tam WH, Lo KWK, Yuen PM BJOG 2000;107(5): 610 - 613 |
| 22 | Complications of Laparoscopic Surgery for Benign Ovarian Cysts. Lok IH, Sahota DS, Rogers MS, Yuen PM J Am Assoc Gyn Lap 2000;7(4): 529 - 534 |
| 23 | Paracervical anaesthesia in outpatient hysteroscopy: a randomised double-blind placebo controlled trial. Lau WC, Yuen PM BJOG 2000;107(1): 143 - 144 |
| 24 | Small bowel herniation through subumbilical port site following laparoscopic surgery at the time of reversal of anesthesia Leung TY, Yuen PM Gynecol Obstet Inves 2000;49(3): 209 - 210 |
| 25 | The role of outpatient diagnostic hysteroscopy in the identifying anatomic pathology and histopathology in the endometrial cavity. Lo KWK, Yuen PM J Am Assoc Gyn Lap 2000;7(3): 381 - 385 |
| 26 | Ectopic pregnancy diagnosed by laparoscopic ultrasound scan. Leung TY, Ng PS, Fung TY Ultrasound Obst Gyn 1999;13(4): 281 - 282 |
| 27 | Mortality following Laparoscopic Surgery. Lo KWK, Yuen PM Gynecol Obstet Inves 1999;48(3): 203 - 204 |
| 28 | Paracervical anaesthesia in outpatient hysteroscopy: a randomised double-blind placebo-controlled trial. Lau WC, Lo KWK, Tam WH, Yuen PM BJOG 1999;106(4): 356 - 359 |
| 29 | Patient's acceptability to outpatient hysteroscopy. Lau WC, Ho RYF, Tsang MK, Yuen PM Gynecol Obstet Inves 1999;47(3): 191 - 193 |
| 30 | Hysteroscopic metroplasty under laparoscopic ultrasound guidance. Lo KWK, Yuen PM Acta Obstet Gyn Scan 1998;77: 580 - 581 |
| 31 | Intraoperative laparoscopic sonography improves pre-operative sonographic pathological characterisation of adnexal masses. Yang WT, Yuen PM, Ho SSY, Leung TN, Metreweli C J Ultras Med 1998;17(1): 53 - 61 |
| 32 | Laparoscopic adnexal ultrasonography: tecnhique in search of an indication. Yang WT, Yuen PM J Ultras Med 1998;17(5): 339 - 340 |
| 33 | Metabolic and inflammatory responses after laparoscopic and abdominal hysterectomy. Yuen PM, Mak TWL, Yim SF, Ngan Kee WD, Lam CWK, Rogers MS, Chang AMZ Am J Obstet Gynecol 1998;179(1): 1 - 5 |
| 34 | 電視腹腔鏡術在子宮內膜異位症診治的應用 Yuen PM, Wong YF Chin J Prac Gynecol Obstet 1997;13(6): 329 - 330 |
| 35 | A randomized prospective study of laparoscopy and laparotomy in the management of benign ovarian masses. Yuen PM, Yu KM, Yip SK, Lau WC, Rogers MS, Chang AMZ Am J Obstet Gynecol 1997;177(1): 109 - 114 |
| 36 | A review of laparoscopy and laparotomy in the management of tubal pregnancy. Yuen PM, Rogers MS, Chang AMZ Hong Kong Med J 1997;3(2): 153 - 157 |
| 37 | Complications of Laparoscopic Hysterectomy: a Literature Review. Yuen PM ELSA 1997;2(2): 36 - 40 |
| 38 | Laparoscopic management of adnexal mass during pregnancy. Yuen PM, Chang AMZ Acta Obstet Gyn Scan 1997;76: 173 - 176 |
| 39 | Controversies in laparoscopic management of ovarian tumours. Yuen PM ELSA 1996;1(4): 84 - 85 |
| 40 | Is laparoscopically-assisted vaginal hysterectomy associatied with low operative morbidity? Yuen PM, Rogers MS Aust NZ J Obstet Gyn 1996;36(1): 39 - 43 |
| 41 | Unexpected ovarian malignancy diagnosed after laparoscopic surgery. Yuen PM, Leung TN Aust NZ J Obstet Gyn 1996;36(1): 98 - 99 |
| 42 | A comparison of laparotomy and laparoscopy in the management of ovarian masses. Yuen PM, Lo KWK, Rogers MS J Gynecol S 1995;11(1): 19 - 25 |
| 43 | Adenomyosis following endometrial rollerball ablation. Yuen PM Aust NZ J Obstet Gyn 1995;35(3): 335 - 336 |
| 44 | Early incisional hernia following laparoscopic surgery. Yuen PM Aust NZ J Obstet Gyn 1995;35(2): 211 - 212 |
| 45 | The use of an Atad Ripener Device in the management of inferior epigastric artery injury during operative laparoscopy. Yuen PM, Rogers MS Acta Obstet Gyn Scan 1995;74(8): 645 - 646 |
| 46 | Transvaginal endoscopic oophorectomy. Yuen PM Am J Obstet Gynecol 1995;173(3): 976 - 977 |
| 47 | Case report: Laparoscopic removal of a retained surgical gauze after vaginal hysterectomy. Yuen PM, Rogers MS, Chang AMZ Eur J Obstet Gyn R B 1994;57(3): 209 - 210 |
| 48 | Combined laparoscopic and micro-laparotomy removal of benign cystic teratomata. Yuen PM BJOG 1994;101(7): 647 - 648 |
| 49 | Laparoscopic hysterectomy: do we need to remove the cervix? Yuen PM, Rogers MS Aust NZ J Obstet Gyn 1994;34(4): 464 - 466 |
| 50 | Laparoscopic management of ovarian masses - the initial experience and learning curve. Yuen PM, Rogers MS Aust NZ J Obstet Gyn 1994;34: 191 - 194 |
| 51 | Laparoscopic removal of ovarian cysts using a zipper storage bag. Yuen PM, Rogers MS Acta Obstet Gyn Scan 1994;73(10): 829 - 831 |
| 52 | Laparoscopic surgery in gynaecology. Yuen PM HK Pract 1994;16(1): 24 - 28 |
| 53 | Wound recurrence by implantation of a borderline ovarian tumour following laparoscopic removal. Yuen PM BJOG 1994;101(11): 1026 - 1027 |
| 54 | Laparoscopic removal of dermoid cysts using Endopouch. Yuen PM, Rogers MS Aust NZ J Obstet Gyn 1993;33(4): 397 - 399 |
| 55 | Endometrial Ablation - Conservative surgery for the treatment of menorrhagia. Lau TK, Leung AKL HK Pract 1991;13: 1737 - 1741 |
| 56 | Endometrium ablation for the treatment of menorrhageia. Wong YF, Leung KL Abroad Med 1991;18: 345 - 347 |
| 57 | Hysteroscopy - A 1990 update. Lau TK, Leung AKL HK Pract 1991;13: 1433 - 1436 |
| 58 | Recent advances in gynaecolgy-laparoscopic CO2 laser surgery. Wong FWS HK Pract 1991;13: 1422 - 1425 |
| 59 | Laparoscopy. Mao KR, Li CY, Chang AMZ HK Pract 1986;8(8): 1969 - 1974 |