Danny SC NG

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Dr Danny SC NG

Associate Professor of Practice in Ophthalmology and Visual Sciences

BSc Hons(Johns Hopkins), MBBS(HKU), MPH(HKU), FRCSEd(Ophth), FCOphthHK, FHKAM(Ophth)

Contact :

(852) 3943 5824

dannyng@cuhk.edu.hk

Request An Appointment :

(852) 3943 5886

eyecentre@cuhk.edu.hk

Academic Appointments

  • Associate Professor of Practice in Ophthalmology and Visual Sciences, Department of Ophthalmology & Visual Sciences, CUHK
  • Vice Director, CUHK Jockey Club Ophthalmic Microsurgical Training Programme
  • Honorary Associate Consultant in Hong Kong Eye Hospital
  • Honorary Associate Consultant in hospitals under the New Territories East Cluster
  • Member, Asia-Pacific Vitreo-retina Society
  • Member, Hong Kong Ophthalmological Society

Biography

Dr. Danny Ng is a clinician scientist with expertise in retinal disease and vitreoretinal surgery.  Prior to medical school, he studied Biomedical Engineering at Johns Hopkins University, United States, where he graduated with honors. As an academic ophthalmologist, Dr. Ng is devoted to training and education. He has taken up the predominant task of implementing unprecedented, structured simulation training for residents and fellows in Hong Kong as Vice Director of the CUHK Jockey Club Ophthalmic Microsurgical Training Programme (CUHK JC OMTP).

Dr. Ng had more than 60 publications in peer reviewed scientific journals, authored 3 book chapters, delivered over 40 conference papers and presented in over 25 invited lectures at international scientific congresses.  He is the principal investigator and grant holder of a number of vigorous research programmes leading to robust characterisation of retinal diseases phenotypes and clinical trials to optimise vision in patients. Dr. Ng is an Executive Committee Member at the Clinical Trials Centre and participated in over 15 sponsored clinical trials.

Dr. Ng was the recipient of the Asia-Pacific Vitreo-retina Society Leadership Development Program Gold Medal Award and Best Self-Initiated Project Award in 2018.  He was also the recipient of the Asia-Pacific Academy of Ophthalmology Achievement Award.  His research was recognized by the Best Scientific Poster Award at the 40th Annual Macular Society.  He served in scientific committees at the World Ophthalmology Congress, Asia-Pacific Academy of Ophthalmology Congresses and Asia-Pacific Vitreo-retina Society Congresses.

As a professional ophthalmologist, Dr. Ng is devoted to public clinical service at the CUHK Eye Centre and Hong Kong Eye Hospital.  He is proficient in cataract surgery, vitrectomy, macular surgery and eyelid surgery.  During subspecialty fellowship, Dr. Ng had overseas training at Bascom Palmer Eye Institute, United States, Samsung Medical Centre, South Korea, and Singapore National Eye Centre.

Research Areas

  1. Imaging in vitreoretinal conditions for diagnosis, disease classification, as biomarker for prognostication, for determining treatment strategy and for monitoring of treatment response.
  2. The natural history and clinical outcomes of pachychoroid disorders such as central serous chorioretinopathy (CSCR),.
  3. Novel therapeutics in retinal and choroidal angiogenesis and cystoid macular oedema.
  4. Pathologic myopia manifestations and therapeutic interventions.
  5. Research of innovative technology for ophthalmic microsurgical education and the translational effect on enhancing clinical outcomes.

Academic Activities

Secretary for Academia, Research, Teaching and Education in Ophthalmology The 34th Asia-Pacific Academy of Ophthalmology Congress 2019 (Bangkok, Thailand)
Leadership Development Programme Asia Pacific Vitreo-retina Society Congress 2018 (Seoul, Korea)
Scientific Program Committee Subspecialty Liaison World Congress of Ophthalmology 2018 (Barcelona, Spain)
Exhibition Committee Chairman The 33rd Asia-Pacific Academy of Ophthalmology Congress 2018 (Hong Kong)
Scientific Committee Member 11th International Symposium of Ophthalmology 2015 (Shantou, China)

Research Highlights

Research Programmes

  1. The clinical safety and efficacy of pharmaceutical and laser interventions in medical retina diseases, including age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC).
  2. Imaging techniques of the choroid and its morphological changes.
  3. Imaging studies and clinical interventions in pathologic myopia.
  4. Phenotype-genotype studies of the role of angiogenesis in medical retina diseases and aging.
  5. The translational benefits of Virtual Reality phacoemulsification cataract extraction simulation training on patient surgical outcomes

Results of Note

  1. Macular diseases with predilection to Asians, including polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSCR), which are especially prevalent in Chinese as compared to Caucasians. Phenotypic studies using advanced ophthalmic imaging with novel computer analytic techniques to reveal microstructure alterations of the choroid, retina and retinal pigment epithelium to elucidate their pathogenic processes. This research area has gained international reputation given our effective detection and treatment of one of the largest study cohorts of PCV and CSCR in the world.
  2. Identification of biomarkers for optimisation of therapeutic response in retinal diseases. Morphology study of choroidal neovascular complex associates with treatment outcomes in pathologic myopia and chronic central serous chorioretinopathy (CSCR). The prime objective is to advance early detection for effective treatment.
  3. Predictors on the natural course of retinal microvascular diseases and early intervention strategies. Optical coherence tomography angiography metrics reveal the progression of retinal microaniopathy. We are establishing effective treatment protocols to prevent blinding outcomes of these patients
  4. Research on innovative technology for ophthalmic microsurgical education and its translation into enhancing patient outcomes. Cost-effective strategies in phacoemulsification cataract extraction surgical simulation training for residents have been established.

Representative Publications:

  1. Ng DSC*, Lai TYY. Insights Into the Global Epidemic of High Myopia and Its Implications. JAMA Ophthalmol. 2021 Dec 16.
  2. Ng DSC*, Ho M, Iu LPL, Lai TYY. Safety review of anti-VEGF therapy in patients with myopic choroidal neovascularization. Expert Opin Drug Saf. 2022 Jan;21(1):43-54.
  3. Ng DS*, Ho M, Chen LJ, Yip FL, Teh WM, Zhou L, Mohamed S, Tsang CW, Brelén ME, Chen H, Pang CP, Lai TYY. Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy. Am J Ophthalmol. 2021 Dec;232:70-82.
  4. Ng DS*, Chan LK, Ng CM, Lai TYY. Visualising the choriocapillaris: Histology, imaging modalities and clinical research. Clin Exp Ophthalmol. 2021 Aug 12. doi: 10.1111/ceo.13984.
  5. Ng DSC*, Fung NSK, Yip FLT, Lai TYY. Ranibizumab for myopic choroidal neovascularization. Expert Opin Biol Ther. 2020 Dec;20(12):1385-1393.
  6. Rong SS, Lee BY, Kuk AK, Yu XT, Li SS, Li J, Guo Y, Yin Y, Osterbur DL, Yam JC, Cheung CY, Chen LJ, Wong TY, Ng DS*. Comorbidity of Dementia and Age-Related Macular Degeneration Calls for Clinical Awareness: A Meta-analysis. Br J Ophthalmol. 2019;0:1–
  7. Sun Z, Tang F, Wong R, Lok J, Szeto SKH, Chan JCK, Chan CKM, Tham CC, Ng DS, Cheung CY. OCT Angiography Metrics Predict Progression of Diabetic Retinopathy and Development of Diabetic Macular Edema: A Prospective Study. Ophthalmology. 2019 Dec;126(12):1675-1684.
  8. Ng DS*, Yip YW, Bakthavatsalam M, Chen LJ, Ng TK, Lai TY, Pang CP, Brelén ME. Elevated angiopoietin 2 in aqueous of patients with neovascular age related macular degeneration correlates with disease severity at presentation. Sci Rep. 2017 Mar 27;7:45081.
  9. Ng DS*, Bakthavatsalam M, Lai FH, Cheung CY, Cheung GC, Tang FY, Tsang CW, Lai TY, Wong TY, Brelén ME. Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1054-1062.
  10. Bakthavatsalam M, Ng DS*, Lai FH, Tang FY, Brelén ME, Tsang CW, Lai TY, Cheung CY. Choroidal structures in polypoidal choroidal vasculopathy, neovascular age-related maculopathy, and healthy eyes determined by binarization of swept source optical coherence tomographic images. Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):935-943.
  11. Huang Y, Huang W, Ng DS, Duan A. Risk factors for development of macular hole retinal detachment after pars plana vitrectomy for pathologic myopic foveoschisis. Retina. 2017 Jun;37(6):1049-1054.
  12. Ng DS*, Kwok AK, Tong JM, Chan CW, Li WW. Factors influencing need for retreatment and long-term visual outcome after intravitreal bevacizumab for myopic choroidal neovascularization. Retina. 2015 Dec;35(12):2457-68.

 

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