Poemen PM CHAN

Research Programmes

1. Ocular Hypertension: risk assessment, treatment approach and the applicability of new imaging technique in the management algorithm.
2. Cost-effectiveness analysis of various glaucoma treatments – particularly, management approaches that could reduce medication use (which constitute the major cost of treatment) and improve quality of life.
3. New surgical techniques and devices of glaucoma surgery – improvement of success rate, reduction of surgical complication and the use of medication.
4. Genetic in glaucoma: Phenotypic characterisation, family linkage, genomic investigation of Juvenile open angle glaucoma and
5. Ocular imaging: new anterior segment devices, risk assessment in primary angle closure glaucoma, microvascular assessment in normal tension glaucoma and primary angle closure glaucoma
6. Primary angle closure disease and normal tension glaucoma – new treatment approaches, risk assessment and ocular imagining

Results of Note

1. Developed a safe, protocol-driven system of reducing medication use for patients with ocular hypertension
2. Established the largest number of ocular hypertensive cohort in the Asian population and currently undergoing a randomized controlled trial.
3. Demonstrated that combined phacotrabeculectomy is more cost-effective than phacoemulsification alone for treating primary angle closure glaucoma, as well as the importance of medication cost and how this would affect the cost-effectiveness of treatment in primary angle closure glaucoma.
4. Demonstrated how different methods of assessing vertical cup-to-disc ratio could affect the risk assessment for untreated ocular hypertensive eyes and how such variability could affect treatment decision.

Representative Publications:

1. Shen R, Wang YM, Cheung CY, Chan PP#, Tham CC. Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma. Sci Rep. 2021 Nov 20;11(1):23136.
2. Chan TCY, Yu MCY, Chiu V, Lai G, Leung CKS, Chan PPM#. Comparison of two novel swept-source optical coherence tomography devices to a partial coherence interferometry-based biometer. Sci Rep. 2021 Jul 21;11(1):14853.
3. Chan PP#, Tang FY, Leung DY, Lam TC, Baig N, Tham CC. Ten-year clinical outcomes of acute primary angle closure randomized to receive early phacoemulsification versus laser peripheral iridotomy. J Glaucoma. 2021 Arp 1;30(4):332-339. – selected as Paper of the month by the Associate Advisory Broad of the World Glaucoma Association.
4. Wong MO, Lai SW, Chan PP, Chan N, Chan A, Chiu V, Lai G, Leung CK. Efficacy and safety of selective laser trabeculoplasty and pattern scanning laser trabeculoplasty – a randomized clinical trial. Br J Ophthalmol. 2021 Apr;105(4):514-520.]
5. Chan PP, Lai, G, Chiu V, Chong A, Yu M, Leung CK. Anterior chamber angle imaging with swept-source optical coherence tomography: comparison between CASIAII and ANTERION. Sci Rep. 2020 Oct 30;10(1):18771.
6. Chan PP#, Wong LY, Chan TC, Lai G, Baig N. The Tenons’ layer repositioning approach of trabeculectomy – a longitudinal case series of a mixed group of glaucoma patients. J Glaucoma. 2020 May;29(5):386-392.
7. AR Ran, CY Cheung, X Wang, H Chen, L Luo, PP Chan, MOM Wong, RT Chang, SS Mannil, AL Young, HW Yung, CP Pang, PA Heng, CC Tham. Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis. The Lancet Digital Health vol.1 no.4 e172-e182 pgs. Elsevier Ltd, 2019.08
8. Chan PP, Pang JC, Tham CC. Acute primary angle closure-treatment strategies, evidences and economical considerations. Eye (Lond). 2019 Jan;33(1):110-119.
9. Chan PP#, Chiu V, Wong MO. Variability of vertical cup to disc ratio measurement and the effects of glaucoma 5-year risk estimation in untreated ocular hypertensive eyes. Br J Ophthalmol. 2019 Mar;103(3):361-368.
10. Chan PP, Li EY, Tsoi KKF, Kwong YY, Tham CC. Cost-effectiveness of phacoemulsification versus combined phacotrabeculectomy for treating primary angle closure glaucoma. J Glaucoma. 2017 Oct;26(10):911-922.
11. Chan PP, Leung CK, Chiu V, Gangwani R, Sharma A, So S, Congdon N. Protocol-driven adjustment of ocular hypotensive medication in patients at low risk of conversion to glaucoma. Br J Ophthalmol. 2015 Sep;99(9):1245-50.

*co-first author; # corresponding author.

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