Prof. DONG Zi Rui, Elvis

Current Position:
Assistant Professor

Office Phone:
(852) 3505 1538

Email:
elvisdong@cuhk.edu.hk

 

ORCID: 0000-0002-3626-6500

Qualifications:
BEng(SCUT); MSc(CUHK); PhD (CUHK)

Research Interests:
Clinical Bioinformatics; Prenatal genetic diagnosis; Genome Sequencing; Genomic Variants

Dr. Dong’s main research interests include:

  1. Development and implementation of low-pass WGS (whole-genome sequencing) assay for identifying clinically significant copy-number variants (CNVs), chromosomal structural rearrangements (SVs, e.g., balanced translocations and inversions) and absence of heterozygosity (AOHs) in prenatal and pediatric cases; 
  2. Deciphering the spectrum of genomic variants (i.e., CNVs, SVs and AOHs) in general population such as the presumably normal subjects in the 1000 Genomes Project to serve as a control_database;
  3. Study on the potential repair mechanism and impact of structural rearrangements (e.g., chromosome insertion and chromothripsis) in human diseases (recurrent miscarriage or male infertility) and embryonic development.

Grants:
Direct Grant (2019.051, 2020.052), HMRF (07186576), HK OG Trust Fund, NSFC (31801042)

1SVInterpreter: A Comprehensive Topologically Associated Domain-Based Clinical Outcome Prediction Tool for Balanced and Unbalanced Structural Variants
Fino J, Marques B, Dong Z, David D
Front Genet. 2021 Dec 1;12:757170
2Trio-Based Low-Pass Genome Sequencing Reveals Characteristics and Significance of Rare Copy Number Variants in Prenatal Diagnosis
Chau MHK, Qian J, Chen Z, Li Y, Zheng Y, Tse WT, Kwok YK, Leung TY, Dong Z, Choy KW
Front Genet. 2021 Sep 20;12:742325
3Low-pass genome sequencing-based detection of absence of heterozygosity: validation in clinical cytogenetics
Dong Z, Chau MHK, Zhang Y, Yang Z, Shi M, Wah YM, Kwok YK, Leung TY, Morton C, Choy KW
Genet Med. 2021 Jul;23(7):1225-1233
4Performance of Cell-Free DNA Screening for Fetal Common Aneuploidies and Sex Chromosomal Abnormalities: A Prospective Study from a Less Developed Autonomous Region in Mainland China
Lai Y, Zhu X, He S, Dong Z, Tang Y, Xu F, Chen Y, Meng L, Tao Y, Yi S, Su J, Huang H, Luo J, Leung TY, Wei H
Genes 2021 Mar;12(4):12040478
5Deciphering the complexity of simple chromosomal insertions by genome sequencing
Dong Z, Chau MHK, Zhang Y, Dai P, Zhu X, Leung TY, Kong X, Kwok YK, Stankiewicz P, Cheung SW, Choy KW
Hum Genet. 2021 Feb;140(2):361-380
6Low-pass genome sequencing: a validated method in clinical cytogenetics   
Chau MHK, Wang H, Lai Y, Zhang Y, Xu F, Tang Y, Wang Y, Chen Z, Leung TY, Chung JPW, Kwok YK, Chong SC, Choy KW, Zhu Y, Xiong L, Wei W, Dong Z             
Hum Genet. 2020 Nov;139(11):1403-1415
7Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis
Wang H, Dong Z, Zhang R, Chau M, Yang Z, Tsang K, Wong HK, Gui B, Meng Z, Xiao K, Zhu X, Wang Y, Chen S, Leung TY, Cheung SW, Kwok YK, Morton CC, Zhu Y, Choy KW
Genet Med, 2020 Mar;22(3):500-510
8Genome Sequencing Explores Complexity of Chromosomal Abnormalities in Recurrent Miscarriage
Dong Z, Yan J, Xu F, Yuan J, Jiang H, Wang H, Chen H, Zhang L, Ye L, Xu J, Shi Y, Yang Z, Cao Y, Chen L, Li Q, Zhao X, Li J, Chen A, Zhang W, Wong HG, Qin Y, Zhao H, Chen Y, Li P, Ma T, Wang WJ, Kwok YK, Jiang Y, Pursley AN, Chung JPW, Hong Yan, Kristiansen K, Yang H, Piña-Aguilar RE, Leung TY, Cheung SW, Morton CC, Choy KW, Chen ZJ
Am J Hum Genet. 2019 Dec 5;105(6):1102-1111
9Prenatal Diagnosis of Fetuses with Increased Nuchal Translucency by Genome Sequencing Analysis
Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YK, Zhu Y, Chen M, Leung TY, Dong Z
Front Genet. 2019 Aug; volume 10:761 (14 pages)
10Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay
Dong Z, Zhao X, Li Q, Yang Z, Xi Y, Alexeev A, Shen H, Wang O, Ruan J, Ren H, Wei H, Qi X, Li J, Zhu X, Zhang Y, Dai P, Kong X, Kirkconnell K, Alferov O, Giles S, Yamtich J, Kermani B, Dong C, Liu P, Mi Z, Zhang W, Xu X, Drmanac R, Choy RKW, Jiang Y
DNA Res. 2019 Aug 1;26(4):313-325
11Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics
Dong Z, Wang H, Chen H, Jiang H, Yuan J, Yang Z, Wang WJ, Xu F, Guo X, Cao Y, Zhu Z, Geng C, Cheung WC, Kwok YK, Yang H, Leung TY, Morton CC, Cheung SW, Choy KW
Genet Med. 2018 Jul;20(7):697-707
12Balanced Chromosomal Rearrangement Detection by Low-Pass Whole-Genome Sequencing
Dong Z, Ye L, Yang Z, Chen H, Yuan J, Wang H, Guo X, Li Y, Wang J, Chen F, Cheung SW, Morton CC, Jiang H, Choy KW
Curr Protoc Hum Genet. 2018 Jan 24;96:8.18.1-8.18
13Copy-Number Variants Detection by Low-Pass Whole-Genome Sequencing
Dong Z, Xie, W, Chen, H, Xu, J, Wang, H, Li, Y, Wang, J, Chen, F, Choy KW, Jiang  H
Curr Protoc Hum Genet  2017 Jul 11;94:8 17 1-8 17 16
14Low-pass Whole-genome Sequencing in Clinical Cytogenetics: A Validated Approach
Dong Z, Zhang J, Hu P, Chen H, Xu J, Tian Q, Meng L, Ye Y, Wang J, Zhang M, Li Y, Wang HL, Yu S, Chen F, Xie J, Jiang H, Wang W, Choy KW, Xu Z
Genet Med Sep 2016;18(9): 940 – 948