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CONTACT INFORMATION
Office : (852) 3505-3308
Email : jiankunxu@cuhk.edu.hk
ACADEMIC ENGAGEMENT
Postgraduate teaching:
MPhil/PhD in Orthopaedics & Traumatology
ORCID: 0000-0003-0280-9930 |
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Professor XU Jiankun, Jerry 許建坤 |
Bachelor of Clinical Medicine (SUMC), Master of Orthopaedics (SUMC), PhD (CUHK)
Assistant Professor of Orthopaedics and Traumatology
矯形外科及創傷學系助理教授
BIOGRAPHY
Professor Xu is an Assistant Professor in the Department of Orthopaedics & Traumatology, the Chinese University of Hong Kong (CUHK). With clinical training background in Orthopaedics and in-depth understanding on musculoskeletal disorders, Professor Xu has devoted himself as an independent clinician-scientist and is good at establishing animal models for orthopaedics research.
Professor Xu has published more than 40 peer-reviewed SCI articles (total impact factor > 200) in regenerative medicine; 50 conference abstracts (most are oral presentations); 3 book chapters; 2 theses. Beyond completing his PhD study on the development of innovative biomaterials for the repair of tendon-bone insertion, he has also contributed greatly (as core member) in other important projects (collaborative research fund, theme-based research fund, and Areas of Excellence fund led by Prof. Qin Ling). For example, Professor Xu has made endeavors to investigate the molecular mechanisms involved in the new bone formation induced by magnesium-based implants and finally found that it is calcitonin-gene related peptide mediating the effect of magnesium. This finding has been recognized by as milestone for the development of magnesium as orthopaedic implants (published in Nature Medicine). This piece of work has been cited for more than 350 times. As principal investigator, he has been funded by the National Natural Science Foundation of China (NSFC, Young Scholar Scheme), Health & Medical Research Fund, Direct Grant from CUHK, and other regional grants. Professor Xu also serves as co-investigator in several General Research Funded (GRF) project from RGC and. In addition, as PI, he has several proposals submitted to compete for GRF and ITF. Above efforts have earned Professor Xu numerous academic awards, including postgraduate research output award from CUHK, Webster Jee young investigator, Savio L.Y. Woo young researcher, and Tigris education fund.
Professor Xu is founding member of Sports Medicine Physician Union in Guangdong-Hong Kong-Macao Greater Bay Area, and members of another ten associations including Hong Kong Scientist Association. He supports peer-review and serves as reviewers for international journals (Biomaterials, Bioactive Materials, American Journal of Sports Medicine, Tissue Engineering (Part A), Journal of Biomedical Materials Research (Part A & Part B), Journal of Orthopaedics Translation, Scientific Reports, and Open Medicine).
EXPERTISE
- Fracture Fixations and Evaluations
- Stem Cell Characterizations and Therapies
- Musculoskeletal Tissue Engineering
SPECIALISED RESEARCH AREAS
- R&D of Biodegradable Implants for Orthopaedic Applications
- Pathologies of Challenging Musculoskeletal Disorders
- Nerve-Vessel-Bone Cross-talks
- Mechanosensitive Factors in Bone, Tendon, and Tendon-Bone Insertions
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SELECTED PUBLICATION
| 1. |
Dai BY, Li X, Xu JK* (co-corresponding), Zhu YW, Huang L, Tong WX, Yao H, Chow DHK, Qin L#. Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss. Bioactive Materials 2021;6(8): 2511-22. |
| 2. |
Wang JL, Xu JK* (equal first), Wang XL, Sheng LY, Zheng LZ, Song B, Wu G, Zhang R, Yao H, Zheng NY, Ong MTY, Yung PSH, Qin L. Magnesium-pretreated periosteum enhances the healing of anterior cruciate ligament reconstruction in rabbits. Biomaterials 2021; 268(3):120576. |
| 3. |
Xu JK*, Wang JL, Chen XD, Li Y, Mi J, Qin L. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Current Osteoporosis Reports 2020;18: 621–32. |
| 4. |
Xu JK*, Hu PJ, Chen JJ, Wang JL, Zhang XT, Zhang JT, Chen ZY, Yu MK, Chung YW, Wang Y, Zhang XH, Zhang YF, Zheng NY, Yao H, Yue J, Chan HC, Qin L#, Ruan YC#. Magnesium rescues cystic fibrosis- and age-related bone diseases through an ATF4-dependent Wnt/β-catenin signaling. SSRN Electronic Journal 2020; doi: 10.2139/ssrn.3550244. |
| 5. |
Feng Q, Xu JK* (equal first), Zhang K, Yao H, Zheng N, Zheng L, Wang J, Wei K, Xiao X, Qin L, and Bian L. Dynamic and cell-Infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects. ACS Central Science. 2019;5(3):440-50. |
| 6. |
Xu JK*, Wang JL, Yue J, Yao H, Zheng NY, Yung SH, Chan KM, Qin L. Novel tendon-derived stem cell sheet secures functional repair of torn rotator cuff through TGF-β3 and IGF-1 signaling. Extended paper for the 17th International Symposium on Ligaments and Tendons (ISL&T-XVII). Page 19-21 (2018). Awarded as Savio L.Y. Woo Young Researcher. |
| 7. |
Xu JK*, Wang JL, Yue J, Zheng NY, Yao H, Ho KW, Yung SH, Qin L. Magnesium stimulates calcitonin gene-related peptide from sensory nerve system to augment the healing of osteoporotic bone fracture. Awarded as Best Oral Presentation in 4th Asia Pacific Bone Mineral Research Conference and Osteoporotic Fracture Prevention & Treatment Conference 2018, Hong Kong SAR & Winner in competing for Tigris Education Fund, supporting to present in Annual Conference of Orthopaedic Research Society held in San Diego, USA. |
| 8. |
XU JK*, Zheng NY, Wang JL, Yao H, Yue J, Ma ZB, Chen HJ, Chen XD, Hu J, Qin L. Targeting CD10+CD26+S100A4+ fibroblasts to ameliorate delayed healing in challenging bone-fractures. ICMRS-Orthopaedic Translational Conference (2018), in Shanghai. Awarded as Young Investigator Best Paper. |
| 9. |
Zhang YF, Xu JK* (equal first), Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y, and Qin L. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine. 2016;22(10):1160-9. |
| 10. |
Xu JK*, Chen HJ, Li XD, Huang ZL, Xu H, Yang HL, and Hu J. Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin beta1-mediated expression of phosphorylated focal adhesion kinase. Journal of Biological Chemistry. 2012;287(31):26200-12. |
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