Biography:

Xiaoqiang Yao, Ph.D., is the Professor in the School of Biomedical Sciences, The Chinese University of Hong Kong. He is one of active scientists in the area of Ca²⁺ signaling and ion channels in cardiovascular system and cancer. His interest include Ca²⁺ signaling, TRP channel regulation, oxidative stress and atherosclerosis, stem cell-derived cardiomyocytes, and cancer progression.

Specialised Research Area(s):

Ion channels and Ca²⁺ signaling

1. Zhu, Y., Xie, M., Meng, Z., Leung, L.K., Chan, F.L., Hu, X., Chi, K., Liu, C.L., & Yao, X. (2019). Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells. Oncogene, 38(29), 5778-5791.

2. Sun, L., Meng, Z., Zhu, Y., Lu, J., Li, Z., Zhao, Q., Huang, Y., Jiang, L.W., & Yao, X. (2018). TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Cell Death & Differentiation, 25(2), 368-379.

3. Lu, J., Boheler, K.R., Jiang, L.W., Chan, C.W., Tse, W.W., Keung, W., Poon, E.N.Y., Li, R.A., & Yao, X. (2018). Polycystin-2 plays an essential role in glucose starvation induced autophagy in human embryonic stem cell derived cardiomyocytes. Stem Cells, 36(4), 501-513.

4. Lau, O.C., Shen, B., Wong, C.O., Tjong, Y.W., Lo, C.Y., Wang, H.C., Huang, Y., Yung, W.H., Chen, Y.C., Fung, M.L., Rudd, J.A., & Yao, X. (2016). TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nature Communications, 7, 11947.

5. Ma, X., Chen, Z., Hua, D., He, D., Wang, L, Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X., Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J., & Yao, X. (2014). Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proceedings of the National Academy of Sciences of the United States of America, 111, 6389-6394.

6. Ma, X., Du, J., Zhang, P., Deng, J., Liu, J., Lam, F.F.Y., Li, R.A., Huang, Y., Jin, J., & Yao, X. (2013). Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension, 62(1), 134-9.

7. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J., & Yao, X. (2012). Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16282-7.

8. Du, J., Wong, W.Y., Sun, L., Huang, Y., & Yao, X. (2012). Protein kinase G regulates flow-induced Ca2+ entry in M1-CCD cells.Journal of the American Society of Nephrology, 23, 1172-80.

9. Kwan, H.Y., Shen, B., Ma, X., Kwok, Y.C., Huang, Y., Man, Y.B., Yu, S., & Yao, X. (2009). TRPC1 Associates With BKCa Channel to Form a Signal Complex in Vascular Smooth Muscle Cells. Circulation Research, 104, 670-678

10. Kwan, H.Y., Huang, Y., & Yao, X. (2004). Regulation of canonical transient receptor potential channel isoforms 3 (TRPC3) by protein kinase G. Proceedings of the National Academy of Sciences of the United States of America, 101, 2625-2630.