Research Assistant Professor at the School of Life Sciences

Office: (852) 3943 6253
Email: wcylau@cuhk.edu.hk
Address: Room 219B, Run Run Shaw Science Building, CUHK

Research Interests

1. Single-particle cryo-electron microscopy (cryo-EM)
2. Structure-function of macromolecular assemblies and membrane proteins
3. Therapeutic interventions
4. Plant biotechnology

Selected Publications

1. Lau WCY, Li Y, Liu Z, Gao Y, Zhang Q, Huen MSY. “Structure of the human dimeric ATM kinase.” Cell Cycle, 2016; 15:1117-24.
2. Roh S, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WCY, Burlingame A, Chiu W, Tweardy DJ. “Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.” Journal of Biological Chemistry, 2016; 291:4732-41.
3. Lau WCY, Li Y, Zhang Q, Huen MSY. “Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA.” Scientific Reports, 2015; 5:15759.
4. Kasembeli M, Lau WCY, Roh S, Eckols Frydman J, Chiu W, Tweardy DJ. “Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin.” PLOS Biology, 2014; 12(4):e1001844.
5. Lau WCY, Rubinstein JL. “Single particle electron microscopy.” Methods in Molecular Biology, 2013; 955:401-26.
6. Lau WCY, Rubinstein JL. “Subnanometer-resolution structure of the intact T. thermophilus H+-driven ATP synthase.” Nature, 2012; 481:214-218 (Recommended by Terrence Frey; Recognized by F1000Prime).
7. Lau WCY, Rubinstein JL. “Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound V(O) motor.” Proceedings of the National Academy of Sciences, 2009; 107:1367-72 (Recommended by Thomas Meier; Recognized by F1000Prime).
8. Lau WCY, Baker LA, Rubinstein JL. “Cryo-EM structure of the yeast ATP synthase.” Journal of Molecular Biology, 2008; 382:1256-1264 (Journal cover).