Circadian Rhythms dysregulation in the unaffected adolescent offspring of parents with bipolar I disorder.
Compared to the offspring of healthy controls (O-HC), the offspring of people with BD (O-BD) have 5-8-fold higher risk for developing BD. Therefore, O-BD is a high-risk population for developing BD, and clinical studies based on this high-risk population should be a critical and feasible approach to understand the precursors and pathogenesis of BD. On the other hand, sleep and circadian dysregulations may underlie the trajectory of BD onset, but more studies are needed to confirm it. In the current study, we investigate the relationship between circadian rhythm dysregulations and BD through comparing different indicators (rhythms of sleep, activity and mood) between O-BD and O-HC. We aim at identifing prodromal features and endophenotypes of BD in order to improve the mental health of O-BD. At the same time, we are planning to do a follow-up every two years to trace the development of BD.
People with bipolar disorder, their spouse, and offspring aged between 6-21 years old
All participants:
