Jan
Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis.
So HC, Chau CK, Cheng YY, Sham PC.
Psychol Med. 2021 Oct;51(14):2357-2369.
doi: 10.1017/S0033291720000951. Epub 2020 Apr 24. PMID: 32329708
The 12-month prevalence of psychotic experiences and their association with clinical outcomes in Hong Kong: an epidemiological and a 2-year follow up studies.
Chan SKW, Lee KKW, Chan VHY, Pang HH, Wong CSM, Hui CLM, Chang WC, Lee EHM, Chan WC, Cheung EFC, Chiu HFK, Chiang TP, Lam M, Lau JTF, Ng RMK, Hung SF, Lam LCW, Chen EYH.
Psychol Med. 2021 Oct;51(14):2501-2508.
doi: 10.1017/S0033291720001452. Epub 2020 May 29. PMID: 32466813
An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study.
Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
Autism Res. 2021 Oct;14(10):2131-2142.
doi: 10.1002/aur.2555. Epub 2021 Jun 11. PMID: 34114351
Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.
Liu L, Ni SY, Yan W, Lu QD, Zhao YM, Xu YY, Mei H, Shi L, Yuan K, Han Y, Deng JH, Sun YK, Meng SQ, Jiang ZD, Zeng N, Que JY, Zheng YB, Yang BN, Gong YM, Ravindran AV, Kosten T, Wing YK, Tang XD, Yuan JL, Wu P, Shi J, Bao YP, Lu L.
EClinicalMedicine. 2021 Oct;40:101111.
doi: 10.1016/j.eclinm.2021.101111. Epub 2021 Sep 8. PMID: 34514362
Associations of circadian factors with insomnia symptoms and emotional and behavioral problems among school-age children.
Sun W, Kwok NTT, Chan NY, Chan JWY, Zhang J, Chan KC, Li SX.
J Clin Sleep Med. 2021 Oct 1;17(10):2107-2114.
doi: 10.5664/jcsm.9346. PMID: 34606443
Neural Response to Rewards in Youths with Insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
Sleep. 2021 Oct 4:zsab238.
doi: 10.1093/sleep/zsab238. Online ahead of print. PMID: 34604904
Progressive Pontine-Medullary Dysfunction Leads to REM Sleep Behavior Disorder Symptoms in a Chronic Model of Parkinson’s Disease.
Du L, Xu L, Liang T, Wing YK, Ke Y, Yung WH.
Nat Sci Sleep. 2021 Oct 5;13:1723-1736.
doi: 10.2147/NSS.S328365. eCollection 2021. PMID: 34675721
Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia – A Multi-National Survey Study.
Brandão LEM, Martikainen T, Merikanto I, Holzinger B, Morin CM, Espie CA, Bolstad CJ, Leger D, Chung F, Plazzi G, Dauvilliers Y, Matsui K, De Gennaro L, Sieminski M, Nadorff MR, Chan NY, Wing YK, Mota-Rolim SA, Inoue Y, Partinen M, Benedict C, Bjorvatn B, Cedernaes J.
Nat Sci Sleep. 2021 Oct 6;13:1711-1722.
doi: 10.2147/NSS.S327365. eCollection 2021. PMID: 34675720
Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.
Wang N, Sun Y, Zhang H, Wang B, Chen C, Wang Y, Chen J, Tan X, Zhang J, Xia F, Qi L, Lu Y.
Eur Heart J. 2021 Oct 21;42(40):4180-4188.
doi: 10.1093/eurheartj/ehab505. PMID: 34374755
Mindfulness Awareness Is Associated With a Lower Risk of Anxiety and Depressive Symptoms in Older Adults With Neurocognitive Disorders.
Lam LCW, Lee ATC, Cheng ST, Yip BHK, Chan WC, Fung AWT, Ma SL, Cheng CPW, Kong R, Chiu HTS, Lai FHY, Wong SYS.
Front Psychiatry. 2021 Oct 21;12:721583.
doi: 10.3389/fpsyt.2021.721583. eCollection 2021. PMID: 34744817
Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide.
Liew SL, Zavaliangos-Petropulu A, Schweighofer N, Jahanshad N, Lang CE, Lohse KR, Banaj N, Barisano G, Baugh LA, Bhattacharya AK, Bigjahan B, Borich MR, Boyd LA, Brodtmann A, Buetefisch CM, Byblow WD, Cassidy JM, Charalambous CC, Ciullo V, Conforto AB, Craddock RC, Dula AN, Egorova N, Feng W, Fercho KA, Gregory CM, Hanlon CA, Hayward KS, Holguin JA, Hordacre B, Hwang DH, Kautz SA, Khlif MS, Kim B, Kim H, Kuceyeski A, Lo B, Liu J, Lin D, Lotze M, MacIntosh BJ, Margetis JL, Mohamed FB, Nordvik JE, Petoe MA, Piras F, Raju S, Ramos-Murguialday A, Revill KP, Roberts P, Robertson AD, Schambra HM, Seo NJ, Shiroishi MS, Soekadar SR, Spalletta G, Stinear CM, Suri A, Tang WK, Thielman GT, Thijs VN, Vecchio D, Ward NS, Westlye LT, Winstein CJ, Wittenberg GF, Wong KA, Yu C, Wolf SL, Cramer SC, Thompson PM; ENIGMA Stroke Recovery Working Group.
Brain Commun. 2021 Oct 27;3(4):fcab254.
doi: 10.1093/braincomms/fcab254. eCollection 2021. PMID: 34805997
Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong.
Ho RYF, Zhang D, Chan SKC, Gao TT, Lee EKP, Lo HHM, Au Yeung P, Lai KYC, Bögels SM, de Bruin EI, Wong SYS.
J Autism Dev Disord. 2021 Nov;51(11):4147-4159.
doi: 10.1007/s10803-020-04729-4. PMID: 33484370
Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Nov;36(11):2184-2192.
doi: 10.1002/jbmr.4406. Epub 2021 Jul 8. PMID: 34184784
The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study.
Chen SJ, Zhang JH, Li SX, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Wing YK, Chan NY.
J Affect Disord. 2021 Nov 1;294:533-542.
doi: 10.1016/j.jad.2021.07.033. Epub 2021 Jul 19. PMID: 34330050
Psychological impact on COVID-19 patients during the outbreak in China: A case-control study.
Lu X, Xie Y, Feng H, Liu Z, Ouyang K, Hou B, Wang M, Kong Z, Zhu Z, Dao W, Zhou Y, Cao J, Long J, Xu Y, Liu Y, Yin X.
Psychiatry Res. 2021 Nov;305:114180.
doi: 10.1016/j.psychres.2021.114180. Epub 2021 Aug 23. PMID: 34461357
Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.
Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T, Ivers H, Wing YK, Chan NY, Merikanto I, Mota-Rolim S, Macêdo T, De Gennaro L, Léger D, Dauvilliers Y, Plazzi G, Nadorff MR, Bolstad CJ, Sieminski M, Benedict C, Cedernaes J, Inoue Y, Han F, Espie CA.
Sleep Med. 2021 Nov;87:38-45.
doi: 10.1016/j.sleep.2021.07.035. Epub 2021 Aug 4. PMID: 34508986
Natural History of REM-OSA in Children and Its Associations with Adverse Blood Pressure Outcomes: A Longitudinal Follow-Up Study.
Chan KC, Au CT, Yu MW, Wing YK, Li AM.
Nat Sci Sleep. 2021 Nov 4;13:1967-1984.
doi: 10.2147/NSS.S331389. eCollection 2021. PMID: 34764712
Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.
Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK.
J Neurol Neurosurg Psychiatry. 2021 Nov 11:jnnp-2021-327460.
doi: 10.1136/jnnp-2021-327460. PMID: 34764151
COVID-19 Vaccine Uptake, Acceptance, and Hesitancy Among Persons With Mental Disorders During the Second Stage of China’s Nationwide Vaccine Rollout.
Huang H, Zhu XM, Liang PW, Fang ZM, Luo W, Ma YM, Zhong BL, Chiu HF.
Front Med (Lausanne). 2021 Nov 11;8:761601.
doi: 10.3389/fmed.2021.761601. eCollection 2021. PMID: 34901076
Effects of COVID-19 on career and specialty choices among Chinese medical students.
Deng J, Que J, Wu S, Zhang Y, Liu J, Chen S, Wu Y, Gong Y, Sun S, Yuan K, Bao Y, Ran M, Shi J, Wing YK, Shi L, Lu L.
Med Educ Online. 2021 Dec;26(1):1913785.
doi: 10.1080/10872981.2021.1913785. PMID: 33849405
Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease.
Li Z, Ip B, Mok VCT, Ko H.
Neural Regen Res. 2021 Dec;16(12):2411-2412.
doi: 10.4103/1673-5374.313042. PMID: 33907022 .
Altered brain activity related to inhibitory processing in youth with insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
J Sleep Res. 2021 Dec;30(6):e13398.
doi: 10.1111/jsr.13398. Epub 2021 Jun 16. PMID: 34137111
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study.
Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT.
Mov Disord. 2021 Dec;36(12):2821-2832.
doi: 10.1002/mds.28763. Epub 2021 Aug 26. PMID: 34448251
Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial.
Mak ADP, Neggers SFW, Leung ONW, Chu WCW, Ho JYM, Chou IWY, Chan SSM, Lam LCW, Lee S.
Int J Bipolar Disord. 2021 Dec 8;9(1):40.
doi: 10.1186/s40345-021-00245-1. PMID: 34877622
Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.
Partinen M, Holzinger B, Morin CM, Espie C, Chung F, Penzel T, Benedict C, Bolstad CJ, Cedernaes J, Chan RNY, Dauvilliers Y, De Gennaro L, Han F, Inoue Y, Matsui K, Leger D, Cunha AS, Merikanto I, Mota-Rolim S, Nadorff M, Plazzi G, Schneider J, Sieminski M, Wing YK, Bjorvatn B.
BMJ Open. 2021 Dec 13;11(12):e050672.
doi: 10.1136/bmjopen-2021-050672. PMID: 34903540
Promoting physical activity and health in Hong Kong primary school children through a blended physical literacy intervention: protocol and baseline characteristics of the “Stand+Move” randomized controlled trial.
Li MH, Sit CHP, Wong SHS, Wing YK, Ng CK, Sum RKW.
Trials. 2021 Dec 20;22(1):944.
doi: 10.1186/s13063-021-05925-y. PMID: 34930404
Comprehensive histological imaging of native microbiota in human glioma.
Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
J Biophotonics. 2021 Dec 22:e202100351.
doi: 10.1002/jbio.202100351. PMID: 34936211
Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID – A multinational ICOSS study.
Merikanto I, Dauvilliers Y, Chung F, Holzinger B, De Gennaro L, Wing YK, Korman M, Partinen M; 2nd ICOSS members.
J Sleep Res. 2021 Dec 28:e13542.
doi: 10.1111/jsr.13542. PMID: 34964184
Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial.
Wong A, Lam BYK, Mak MKY, Lam LCW, Au LWC, Yiu BKF, Wong C, Tong HY, Yeung SK, Chu WCW, Shi L, Leung TWH, Soo YOY, Lau AYL, Ip BYM, Kwok TCY, Ko H, Mok VCT.
Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12224.
doi: 10.1002/trc2.12224. eCollection 2021. PMID: 35005205
A bidirectional association between internet addiction and depression: A large-sample longitudinal study among Chinese university students.
Yang X, Guo WJ, Tao YJ, Meng YJ, Wang HY, Li XJ, Zhang YM, Zeng JK, Tang WJ, Wang Q, Deng W, Zhao LS, Ma XH, Li ML, Xu JJ, Li J, Liu YS, Tang Z, Du XD, Hao W, Coid JW, Lee S, Greenshaw AJ, Li T.
J Affect Disord. 2022 Feb 15;299:416-424.
doi: 10.1016/j.jad.2021.12.013. Epub 2021 Dec 11. PMID: 34906641
Jan
Professor WING Yun Kwok and Dr CHAU Steven Wai Ho were awarded $10 Million in RGC’s Collaborative Research Fund 2021/22
Professor WING Yun Kwok
Title: Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alphasynucleinopathy Neurodegeneration, in a Prospective Family Cohort
Funded: $7,214,620
Dr CHAU Steven Wai Ho
Title: Neuropsychiatric’ Long-COVID’ in Adult Patients
Funded: $3,251,480
Dec
Dr. Allen Lee received Best Poster Award in the 15th International Congress of the Asian Society Against Dementia (ASAD2021)
Dr. Allen Lee’s abstract titled “Structured frontal lobe based computerized cognitive stimulation to older adults with subjective cognitive complaints and comorbid depression symptoms” was one of the 18 posters selected for oral presentation in the 15th International Congress of the Asian Society Against Dementia (ASAD2021), which was held in a hybrid format in November 2021 in Sendai, Japan.
Dr. Lee’s oral presentation was well received by the audience from Japan and around the world and was subsequently awarded for the Best Poster Award.
His abstract described the positive preliminary findings of his pilot randomized controlled trial of structured frontal lobe based computerized cognitive training in older adults with depression but without mild cognitive impairment or dementia. This pilot study was supported by the CUHK Direct Grant for Research, where Dr. Lee was the Principal Investigator. A larger, longer and more in-depth study could potentially generate the much-needed clinical and scientific evidence of computerized cognitive training being an effective alternative or adjuvant intervention for depression in older adults.
Dec
Dr. LU Hanna is appointed as the editorial board member of BMC Medicine
From Oct 2021, Dr. LU Hanna is appointed as the editorial board member of BMC Medicine (https://bmcmedicine.biomedcentral.com/). BMC Medicine is the flagship medical journal of the BMC series (2-year IF: 8.775; 5-year IF: 10.249). An open access, transparent peer-reviewed general medical journal, BMC Medicine publishes outstanding and influential research in all areas of clinical practice, translational medicine, medical and health advances, public health, global health, and general topics of interest to the biomedical and sociomedical professional communities.
Oct
The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.
Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL.
Ophthalmology. 2021 Jul;128(7):981-992.
doi: 10.1016/j.ophtha.2020.12.010. Epub 2021 Feb 27. PMID: 33333104.
Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.
Au CT, Chan KCC, Lee DLY, Leung N, Chow SMW, Chow JS, Wing YK, Li AM.
Respirology. 2021 Jul;26(7):690-699.
doi: 10.1111/resp.14050. Epub 2021 Apr 1. PMID: 33793018.
Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.
Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A.
Brain Commun. 2021 Jun 3;3(3):fcab124.
doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID:PMC8249101.
Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder.
Si FF, Liu L, Li HM, Sun L, Cao QJ, Lu H, Wang YF, Qian QJ.
Psychiatry Investig. 2021 Jul;18(7):679-687.
doi: 10.30773/pi.2020.0333. Epub 2021 Jul 22. PMID: 34340276; PMCID: PMC8328834.
Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.
Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J.
Nutrients. 2021 Jul 5;13(7):2313.
doi: 10.3390/nu13072313. PMID: 34371826; PMCID: PMC8308783.
MRI-Based Geometric Modeling for Personalized Transcranial Magnetic Stimulation in Age-Related Neurodegenerative Diseases.
Lu H.
Front Neurosci. 2021 Jul 22;15:685424.
doi: 10.3389/fnins.2021.685424. PMID: 34366775; PMCID: PMC8339904.
Cardiovascular risks of children with primary snoring: A 5-year follow-up study.
Au CT, Chan KC, Chook P, Wing YK, Li AM.
Respirology. 2021 Aug;26(8):796-803.
doi: 10.1111/resp.14089. Epub 2021 May 30. PMID: 34056796.
Personalized prediction of repetitive transcranial magnetic stimulation clinical response in medication-refractory depression data.
Hopman H, Chan S, Chu W, Lu H, Tse CY, Chau S, Lam L, Mak A, Neggers S.
Data Brief. 2021 Jul 14;37:107264.
doi: 10.1016/j.dib.2021.107264. PMID: 34345639; PMCID: PMC8319357.
Do people with mental health problems have lower adherence to precautionary measures in COVID-19 pandemic? A cross-sectional observational study in Hong Kong.
Lee ATC, Cheng GWH, Lin C, Wong BHC, Lam LCW.
BMJ Open. 2021 Aug 12;11(8):e046658.
doi: 10.1136/bmjopen-2020-046658. PMID: 34385242; PMCID: PMC8361707.
Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort.
Lei B, Zhang J, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK.
Sleep. 2021 Aug 13;44(8):zsab053.
doi: 10.1093/sleep/zsab053. PMID: 33640972.
Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.
Rao S, Yin L, Xiang Y, So HC.
Transl Psychiatry. 2021 Aug 13;11(1):426.
doi: 10.1038/s41398-021-01545-x. PMID: 34389699; PMCID: PMC8363629.
Inpatient Stay for Older Adults: A Double-edged Sword for Cognition? Inpatient Stay for Older Adults: A Double-edged Sword for Cognition?
Lee ATC, Chiu HFK.
Int Psychogeriatr. 2021 Aug 16:1-5.
doi: 10.1017/S1041610221001137. Epub ahead of print. PMID: 34392863.
Childhood adversities and suicidal thoughts and behaviors among first-year college students: results from the WMH-ICS initiative.
Mortier P, Alonso J, Auerbach RP, Bantjes J, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Green JG, Hasking P, Karyotaki E, Kiekens G, Mak A, Nock MK, O’Neill S, Pinder-Amaker S, Sampson NA, Stein DJ, Vilagut G, Wilks C, Zaslavsky AM, Mair P, Kessler RC; WHO WMH-ICS Collaborators.
Soc Psychiatry Psychiatr Epidemiol. 2021 Aug 23.
doi: 10.1007/s00127-021-02151-4. Epub ahead of print. PMID: 34424350.
Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic – Multinational study on 19,267 adults.
Merikanto I, Kortesoja L, Benedict C, Chung F, Cedernaes J, Espie CA, Morin CM, Dauvilliers Y, Partinen M, De Gennaro L, Wing YK, Chan NY, Inoue Y, Matsui K, Holzinger B, Plazzi G, Mota-Rolim SA, Leger D, Penzel T, Bjorvatn B.
Sleep. 2021 Aug 25:zsab216.
doi: 10.1093/sleep/zsab216. Epub ahead of print. PMID: 34432058; PMCID: PMC8499764.
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study.
Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT.
Mov Disord. 2021 Aug 26.
doi: 10.1002/mds.28763. Epub ahead of print. PMID: 34448251.
Are Care-Recipient Outcomes Attributable to Improved Caregiver Well-Being? A Cluster-Randomized Controlled Trial of Benefit-Finding Intervention.
Cheng ST, Chan WC, Lam LCW.
Am J Geriatr Psychiatry. 2021 Aug 28:S1064-7481(21)00452-8.
doi: 10.1016/j.jagp.2021.08.009. Epub ahead of print. PMID: 34563429.
Wilson Sims Fall Risk Assessment Tool Versus Morse Fall Scale in Psychogeriatric Inpatients: a Multicentre Study.Wilson Sims Fall Risk Assessment Tool Versus Morse Fall Scale in Psychogeriatric Inpatients: a Multicentre Study.
Wong MMC, Pang PF, Chan CF, Lau MS, Tse WY, Lam LCW, Lee SKL, Tsoh J, Yan CTY.
East Asian Arch Psychiatry. 2021 Sep;31(3):67-70.
doi: 10.12809/eaap2113. PMID: 34588316.
Computer-Assisted Cognitive Training for Patients with Severe Mental Illness: a Retrospective Study.
Lau CM, Tang WK.
East Asian Arch Psychiatry. 2021 Sep;31(3):71-80.
doi: 10.12809/eaap2097. PMID: 34588317.
Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK.
Eur Heart J. 2021 Sep 7;42(34):3349-3357.
doi: 10.1093/eurheartj/ehab170. PMID: 33822910.
Exploring Drugs and Vaccines Associated with Altered Risks and Severity of COVID-19: A UK Biobank Cohort Study of All ATC Level-4 Drug Categories Reveals Repositioning Opportunities.
Xiang Y, Wong KC, So HC.
Pharmaceutics. 2021 Sep 18;13(9):1514.
doi: 10.3390/pharmaceutics13091514. PMID: 34575590; PMCID: PMC8471264.
Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.
Chan JW, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, Zhang J, Wing YK.
J Clin Sleep Med. 2021 Sep 21.
doi: 10.5664/jcsm.9648. Epub ahead of print. PMID: 34534071.
How our Dreams Changed During the COVID-19 Pandemic: Effects and Correlates of Dream Recall Frequency – a Multinational Study on 19,355 Adults.
Fränkl E, Scarpelli S, Nadorff MR, Bjorvatn B, Bolstad CJ, Chan NY, Chung F, Dauvilliers Y, Espie CA, Inoue Y, Leger D, Macêdo T, Matsui K, Merikanto I, Morin CM, Mota-Rolim S, Partinen M, Penzel T, Plazzi G, Sieminski M, Wing YK, De Gennaro L, Holzinger B.
Nat Sci Sleep. 2021 Sep 22;13:1573-1591.
doi: 10.2147/NSS.S324142. PMID: 34588830; PMCID: PMC8473566.
Uncovering Clinical Risk Factors and Predicting Severe COVID-19 Cases Using UK Biobank Data: Machine Learning Approach.
Wong KC, Xiang Y, Yin L, So HC.
JMIR Public Health Surveill. 2021 Sep 30;7(9):e29544.
doi: 10.2196/29544. PMID: 34591027; PMCID: PMC8485986.
Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.
Liu L, Ni SY, Yan W, Lu QD, Zhao YM, Xu YY, Mei H, Shi L, Yuan K, Han Y, Deng JH, Sun YK, Meng SQ, Jiang ZD, Zeng N, Que JY, Zheng YB, Yang BN, Gong YM, Ravindran AV, Kosten T, Wing YK, Tang XD, Yuan JL, Wu P, Shi J, Bao YP, Lu L.
EClinicalMedicine. 2021 Oct;40:101111.
doi: 10.1016/j.eclinm.2021.101111. Epub 2021 Sep 8. PMID: 34514362; PMCID: PMC8424080.
Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Nov;36(11):2184-2192.
doi: 10.1002/jbmr.4406. Epub 2021 Jul 8. PMID: 34184784.
The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study.
Chen SJ, Zhang JH, Li SX, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Wing YK, Chan NY.
J Affect Disord. 2021 Nov 1;294:533-542.
doi: 10.1016/j.jad.2021.07.033. Epub 2021 Jul 19. PMID: 34330050.
Psychological impact on COVID-19 patients during the outbreak in China: A case-control study.
Lu X, Xie Y, Feng H, Liu Z, Ouyang K, Hou B, Wang M, Kong Z, Zhu Z, Dao W, Zhou Y, Cao J, Long J, Xu Y, Liu Y, Yin X.
Psychiatry Res. 2021 Nov;305:114180.
doi: 10.1016/j.psychres.2021.114180. Epub 2021 Aug 23. PMID: 34461357; PMCID: PMC8381686.
Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study. Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.
Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T, Ivers H, Wing YK, Chan NY, Merikanto I, Mota-Rolim S, Macêdo T, De Gennaro L, Léger D, Dauvilliers Y, Plazzi G, Nadorff MR, Bolstad CJ, Sieminski M, Benedict C, Cedernaes J, Inoue Y, Han F, Espie CA.
Sleep Med. 2021 Nov;87:38-45.
doi: 10.1016/j.sleep.2021.07.035. Epub 2021 Aug 4. PMID: 34508986; PMCID: PMC8425785.
Jul
Intermediate phenotypes of childhood obstructive sleep apnea.
Au CT, Chan KC, Zhang J, Liu KH, Chu WCW, Wing YK, Li AM.
J Sleep Res. 2021 Jun;30(3):e13191.
doi: 10.1111/jsr.13191. Epub 2020 Sep 14. PMID: 32926500.
Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
Neuropathol Appl Neurobiol. 2021 Apr;47(3):441-453.
doi: 10.1111/nan.12673. Epub 2020 Dec 2. PMID: 33107057; PMCID: PMC8048831.
Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.
Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
Front Neurosci. 2021 Apr 27;15:649588.
doi: 10.3389/fnins.2021.649588. PMID: 33986640; PMCID: PMC8111170.
The Effects of Repetitive Transcranial Magnetic Stimulation Antidepressant Response on Cold Cognition: A Single-Arm Prospective Longitudinal Study.
Hopman HJ, Choy HY, Ho WS, Lu H, Wong WHO, Chan SMS.
Neuropsychiatr Dis Treat. 2021 May 26;17:1647-1658.
doi: 10.2147/NDT.S307119. PMID: 34079262; PMCID: PMC8165208.
Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.
Au CT, Chan KCC, Lee DLY, Leung N, Chow SMW, Chow JS, Wing YK, Li AM.
Respirology. 2021 Jul;26(7):690-699.
doi: 10.1111/resp.14050. Epub 2021 Apr 1. PMID: 33793018.\
An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.
Phiri P, Ramakrishnan R, Rathod S, Elliot K, Thayanandan T, Sandle N, Haque N, Chau SW, Wong OW, Chan SS, Wong EK, Raymont V, Au-Yeung SK, Kingdon D, Delanerolle G.
EClinicalMedicine. 2021 Apr;34:100806.
doi: 10.1016/j.eclinm.2021.100806. Epub 2021 Apr 6. PMID: 33842872; PMCID: PMC8022621.
Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK.
Eur Heart J. 2021 Apr 5:ehab170.
doi: 10.1093/eurheartj/ehab170. Epub ahead of print. PMID: 33822910.
History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002-2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
Chau SWH, Wong OWH, Ramakrishnan R, Chan SSM, Wong EKY, Li PYT, Raymont V, Elliot K, Rathod S, Delanerolle G, Phiri P.
BMC Public Health. 2021 Apr 7;21(1):670.
doi: 10.1186/s12889-021-10701-3. PMID: 33827499; PMCID: PMC8025448.
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL.
ACS Cent Sci. 2021 May 26;7(5):792-802.
doi: 10.1021/acscentsci.0c01186. Epub 2021 Apr 15. PMID: 34075346; PMCID: PMC8056950.
The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study.
Chung F, Waseem R, Pham C, Penzel T, Han F, Bjorvatn B, Morin CM, Holzinger B, Espie CA, Benedict C, Cedernaes J, Saaresranta T, Wing YK, Nadorff MR, Dauvilliers Y, De Gennaro L, Plazzi G, Merikanto I, Matsui K, Leger D, Sieminski M, Mota-Rolim S, Inoue Y, Partinen M; International COVID Sleep Study (ICOSS) group.
Sleep Breath. 2021 Jun;25(2):849-860.
doi: 10.1007/s11325-021-02373-5. Epub 2021 Apr 28. PMID: 33907966; PMCID: PMC8079162.
Knowledge of mental health symptoms and help seeking attitude in a population-based sample in Hong Kong.
Fung AWT, Lam LCW, Chan SSM, Lee S.
Int J Ment Health Syst. 2021 Apr 28;15(1):39.
doi: 10.1186/s13033-021-00462-2. PMID: 33910611; PMCID: PMC8080995.
Mental Health and Psychological Responses During the Coronavirus Disease 2019 Epidemic: A Comparison Between Wuhan and Other Areas in China.
Wang Q, Feng H, Wang M, Xie Y, Hou B, Lu X, Liu Z, Ouyang K, Zhang R, Cai Q, Xu Z, Li H, Chao H, Yang X, Hong Y, Hu X, Liu Z, Liu Y.
Psychosom Med. 2021 May 1;83(4):322-327.
doi: 10.1097/PSY.0000000000000892. PMID: 33284256.
The Differential Effects of Social Media on Depressive Symptoms and Suicidal Ideation Among the Younger and Older Adult Population in Hong Kong During the COVID-19 Pandemic: Population-Based Cross-sectional Survey Study.
Yang X, Yip BHK, Mak ADP, Zhang D, Lee EKP, Wong SYS.
JMIR Public Health Surveill. 2021 May 25;7(5):e24623.
doi: 10.2196/24623. PMID: 33835937; PMCID: PMC8153033.
A framework to decipher the genetic architecture of combinations of complex diseases: Applications in cardiovascular medicine.
Yin L, Chau CK, Lin YP, Rao S, Xiang Y, Sham PC, So HC.
Bioinformatics. 2021 May 29:btab417.
doi: 10.1093/bioinformatics/btab417. Epub ahead of print. PMID: 34050728.
Cardiovascular risks of children with primary snoring: A 5-year follow-up study.
Au CT, Chan KC, Chook P, Wing YK, Li AM.
Respirology. 2021 Aug;26(8):796-803.
doi: 10.1111/resp.14089. Epub 2021 May 30. PMID: 34056796.
Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H.
Commun Biol. 2021 Jun 2;4(1):656.
doi: 10.1038/s42003-021-02208-9. PMID: 34079050; PMCID: PMC8172568.
Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.
Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A.
Brain Commun. 2021 Jun 3;3(3):fcab124.
doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID: PMC8249101.
An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study.
Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
Autism Res. 2021 Jun 11.
doi: 10.1002/aur.2555. Epub ahead of print. PMID: 34114351.
Altered brain activity related to inhibitory processing in youth with insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
J Sleep Res. 2021 Jun 16:e13398.
doi: 10.1111/jsr.13398. Epub ahead of print. PMID: 34137111.
Non-suicidal self-injury among first-year college students and its association with mental disorders: results from the World Mental Health International College Student (WMH-ICS) initiative.
Kiekens G, Hasking P, Bruffaerts R, Alonso J, Auerbach RP, Bantjes J, Benjet C, Boyes M, Chiu WT, Claes L, Cuijpers P, Ebert DD, Mak A, Mortier P, O’Neill S, Sampson NA, Stein DJ, Vilagut G, Nock MK, Kessler RC; WHO World Mental Health International College Student (WMH-ICS) collaborators.
Psychol Med. 2021 Jun 18:1-12.
doi: 10.1017/S0033291721002245. Epub ahead of print. PMID: 34140062.
Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong.
Gao L, Leung MTY, Li X, Chui CSL, Wong RSM, Au Yeung SL, Chan EWW, Chan AYL, Chan EW, Wong WHS, Lee TMC, Rao N, Wing YK, Lum TYS, Leung GM, Ip P, Wong ICK.
BMJ Open. 2021 Jun 22;11(6):e045868.
doi: 10.1136/bmjopen-2020-045868. PMID: 34158297; PMCID: PMC8220454.
Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Jun 29.
doi: 10.1002/jbmr.4406. Epub ahead of print. PMID: 34184784.
Apr
The clinical characteristics of cataplectic attack in narcolepsy type 1.
Huang B, Xu T, Wang Z, Chen K, Zhang J, Zhao Z, Zhuang J, Wu H.
Sleep Med. 2021 Jan;77:261-269. doi: 10.1016/j.sleep.2019.03.015. Epub 2019 Apr 3. PMID:31607435.
Moment-to-moment dynamics between auditory verbal hallucinations and negative affect and the role of beliefs about voices.
So SH, Chung LK, Tse CY, Chan SS, Chong GH, Hung KS, Sommer IEC.
Psychol Med. 2021 Mar;51(4):661-667. doi:10.1017/S0033291719003611. Epub 2020 Jan 7. PMID: 31907105.
Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries.
Molodynski A, Lewis T, Kadhum M, Farrell SM, Lemtiri Chelieh M, Falcão De Almeida T, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau
SWH, Wilkes C, Bhugra D.
Int Rev Psychiatry. 2021 Feb-Mar;33(1-2):37-42. doi: 10.1080/09540261.2020.1738064. Epub 2020 Mar 18. PMID:32186412.
Urban-rural disparities in mental health problems related to COVID-19 in China.
Liu L, Xue P, Li SX, Zhang J, Zhou J, Zhang W.
Gen Hosp Psychiatry. 2021 Mar-Apr;69:119-120. doi: 10.1016/j.genhosppsych.2020.07.011. Epub 2020 Aug 2. PMID: 32868097; PMCID: PMC7395944.
A randomised controlled trial of metacognitive training for psychosis, depression, and belief flexibility.
Ho-Wai So S, Hoi-Kei Chan G, Kit-Wa Wong C, Wing-Ka Ching E, Sze-Wai Lee S, Chi-Wing Wong B, Zhu C, Sun X, Kin-Hei Chung L, Hung AY, Oi-Yin Wong J, Sau-Man Chan S.
J Affect Disord. 2021 Jan 15;279:388-397. doi: 10.1016/j.jad.2020.09.126. Epub 2020 Oct 6. PMID: 33099054.
Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
So SH, Mak AD, Chan PS, Lo CC, Na S, Leung MH, Ng IH, Chau AKC, Lee S.
J Affect Disord. 2021 Feb 15;281:949-957. doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18. PMID: 33229019.
Letter to Editor.
Zhang C, Tang WK.
Psychiatry Res. 2021 Feb;296:113602. doi: 10.1016/j.psychres.2020.113602. Epub 2020 Nov 26. PMID: 33279254.
Current Status of Tissue Clearing and the Path Forward in Neuroscience.
Zhao J, Lai HM, Qi Y, He D, Sun H.
ACS Chem Neurosci. 2021 Jan 6;12(1):5-29. doi: 10.1021/acschemneuro.0c00563. Epub 2020 Dec 16. PMID: 33326739.
The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.
Lui TK, Shum YH, Xiao XZ, Wang Y, Cheung AT, Chan SS, Neggers SFW, Tse CY.
Brain Stimul. 2021 Jan-Feb;14(1):161-169. doi: 10.1016/j.brs.2020.12.005. Epub 2020 Dec 17. PMID: 33346067.
Risk of incident dementia varies with different onset and courses of depression.
Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
J Affect Disord. 2021 Mar 1;282:915-920. doi: 10.1016/j.jad.2020.12.195. Epub 2020 Dec 30. PMID: 33601735.
Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling.
Lu H, Li J, Zhang L, Chan SSM, Lam LCW;
J Neuroeng Rehabil. 2021 Jan 4;18(1):2. doi: 10.1186/s12984-020-00764-5. PMID:33397402; PMCID: PMC7784346.
White matter integrity in young medication-naïve bipolar II depressed adults.
Mak ADP, Leung ONW, Chou IWY, Wong SLY, Chu WC, Yeung D, So SH, Ma SL, Lam LCW, Leung CM, Lee S.
Sci Rep. 2021 Jan 19;11(1):1816. doi:10.1038/s41598-021-81355-9. PMID: 33469064; PMCID: PMC7815920.
Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong.
Ho RYF, Zhang D, Chan SKC, Gao TT, Lee EKP, Lo HHM, Au Yeung P, Lai KYC, Bögels SM, de Bruin EI, Wong SYS.
J Autism Dev Disord. 2021 Jan 23. doi: 10.1007/s10803-020-04729-4. Epub ahead of print. PMID: 33484370.
Promoting Resilience in the Age of COVID-19 Pandemic: A New Era of Strategic Foresight.
Lu H, Li J, Ni X.
Aging Dis. 2021 Feb 1;12(1):1-2. doi:10.14336/AD.2020.1011. PMID: 33532120; PMCID: PMC7801285.
The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.
Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL.
Ophthalmology. 2021 Feb 26:S0161-6420(20)31158-1. doi:10.1016/j.ophtha.2020.12.010. Epub ahead of print. PMID: 33333104.
Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort.
Lei B, Zhang J, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK.
Sleep. 2021 Feb 26:zsab053. doi: 10.1093/sleep/zsab053. Epub ahead of print. PMID:33640972.
Exercise for the prevention and treatment of neurocognitive disorders: new evidence and clinical recommendations.
Chan WC, Lee ATC, Lam LCW.
Curr Opin Psychiatry. 2021 Mar 1;34(2):136-141. doi: 10.1097/YCO.0000000000000678. PMID:33470667.
Achieving better outcomes for schizophrenia patients in Hong Kong: Strategies for improving treatment adherence.adherence.
Lo WA, Ki-Yan Mak D, Ming-Cheuk Wong M, Chan OW, Mo-Ching Chui E, Wai-Sau Chung D, Suk-Han Ip G, Lau KS, Lee CK, Mui J, Tam KL, Tse S, Wong KL; Hong Kong Association of Psychosocial Rehabilitation (HKAPR).
CNS Neurosci Ther. 2021 Mar;27 Suppl 1(Suppl 1):12-19. doi:10.1111/cns.13375. PMID: 33555616; PMCID: PMC7869929.
A Prevention Program for Insomnia in At-risk Adolescents: A Randomized Controlled Study.
Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, Yu MWM, Chan JWY, Li AM, Morin CM, Wing YK.
Pediatrics. 2021 Mar;147(3):e2020006833. doi:10.1542/peds.2020-006833. PMID: 33627370.
Prevalence of depressive symptoms among Chinese university students amid the COVID-19 pandemic: a systematic review and meta-analysis.
Luo W, Zhong BL, Chiu HF.
Epidemiol Psychiatr Sci. 2021 Mar 26;30:e31. doi:10.1017/S2045796021000202. PMID: 33766163; PMCID: PMC8047400.
Apr
CUHK Study Proves Genetically Predicted Short Sleep Duration Rather Than Long Sleep Duration as a Potential Causal Risk Factor for Many Cardiovascular Diseases
Sleep is vital to individual’s cardiovascular health. A handful of observational studies have suggested that both short (≤ 6 hours) and long (≥ 9 hours) sleep durations are associated with many cardiovascular diseases (CVDs). However, traditional observational studies, even they are well designed, prospective with large sample sizes, are prone to be biased by residual confounding effects and reverse causation. Therefore, the causal associations between sleep duration and CVDs remains unclear.
Research team from the Li Chiu Kong Family Sleep Assessment Unit, at the Department of Psychiatry, led by Professor Yun-Kwok Wing, performed a study entitled “Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank”. In collaboration with several institutes, including Peking University, Sichuan University, etc, we employed linear and nonlinear Mendelian randomization (MR) analyses to investigate the causal associations of short and long sleep durations with 12 cardiovascular diseases in UK Biobank. We found that genetically predicted sleep duration was associated with arterial hypertension, atrial fibrillation, pulmonary embolism, and chronic ischaemic heart disease. Complementary analyses provided confirmative evidence of the adverse effects of genetically predicted short sleep duration on the risks of 5 out of the 12 CVDs, including arterial hypertension, pulmonary embolism, coronary artery disease, myocardial infarction, and chronic ischaemic heart disease. However, genetically predicted long sleep duration was not associated with any CVD. The findings of this study have significant implications in the prevention of CVDs. These results suggested that increasing sleep duration among those with short sleep duration may promote cardiovascular health for them, while simply reducing sleep per se is not likely to improve cardiovascular health in people with long sleep duration (Graphical Abstract).
This project was supported by the Impact Postdoctoral Fellowship Scheme of The Chinese University of Hong Kong.
These novel findings have been published in the European Heart Journal (Impact factor: 22.673; Rank: 2/138 in the field of CARDIAC & CARDIOVASCULAR SYSTEMS).
Graphical Abstract. Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
Article in European Heart Journal
“Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank” by Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK.
https://pubmed.ncbi.nlm.nih.gov/33822910/
Mar
CUHK-HKU-UL Conducts World’s First Insomnia Prevention Programme and Proves Insomnia is Preventable in At-risk Adolescents
Adolescence is a critical period accompanied by dramatic neurobiological, physical, behavioural and emotional changes, predisposing the youngsters to sleep disorders, mental and physical illnesses. It is a vulnerable period for the emergence of insomnia, affecting 10% to 36% of the adolescents. Insomnia once developed, tends to run a chronic course with considerable personal distress and health care burden.
Jan
The associations of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in adolescents.
Chan NY, Zhang J, Tsang CC, Li AM, Chan JWY, Wing YK, Li SX.
Sleep Med. 2020 Oct;74:124-131. doi: 10.1016/j.sleep.2020.05.035. Epub 2020 Jun 3. PMID: 32853897.
The mental health of frontline and non-frontline medical workers during the coronavirus disease 2019 (COVID-19) outbreak in China: A case-control study.
Cai Q, Feng H, Huang J, Wang M, Wang Q, Lu X, Xie Y, Wang X, Liu Z, Hou B, Ouyang K, Pan J, Li Q, Fu B, Deng Y, Liu Y.
J Affect Disord. 2020 Oct 1;275:210-215. doi: 10.1016/j.jad.2020.06.031. Epub 2020 Jul 2. PMID: 32734910; PMCID: PMC7329671.
Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.
Makkar SR, Lipnicki DM, Crawford JD, Kochan NA, Castro-Costa E, Lima-Costa MF, Diniz BS, Brayne C, Stephan B, Matthews F, Llibre-Rodriguez JJ, Llibre-Guerra JJ, Valhuerdi-Cepero AJ, Lipton RB, Katz MJ, Zammit A, Ritchie K, Carles S, Carriere I, Scarmeas N, Yannakoulia M, Kosmidis M, Lam L, Fung A, Chan WC, Guaita A, Vaccaro R, Davin A, Kim KW, Han JW, Suh SW, Riedel-Heller SG, Roehr S, Pabst A, Ganguli M, Hughes TF, Jacobsen EP, Anstey KJ, Cherbuin N, Haan MN, Aiello AE, Dang K, Kumagai S, Narazaki K, Chen S, Ng TP, Gao Q, Nyunt MSZ, Meguro K, Yamaguchi S, Ishii H, Lobo A, Lobo Escolar E, De la Cámara C, Brodaty H, Trollor JN, Leung Y, Lo JW, Sachdev P; for Cohort Studies of Memory in an International Consortium (COSMIC).
Arch Gerontol Geriatr. 2020 Nov/Dec;91:104112. doi: 10.1016/j.archger.2020.104112. Epub 2020 Jul 13. PMID: 32738518; PMCID: PMC7724926.
Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-up Study.
Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK.
Mov Disord. 2020 Nov;35(11):2077-2085. doi: 10.1002/mds.28210. Epub 2020 Aug 3. PMID: 32744735.
Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future.
Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P.
Alzheimers Dement. 2020 Nov;16(11):1571-1581. doi: 10.1002/alz.12143. Epub 2020 Aug 12. PMID: 32789951; PMCID: PMC7436526.
Rest-Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SX, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK, Zhang J.
Ann Neurol. 2020 Oct;88(4):817-829. doi:10.1002/ana.25853. Epub 2020 Aug 18. PMID: 32691442.
Sleep duration in preschool children and impact of screen time.
Lan QY, Chan KC, Yu KN, Chan NY, Wing YK, Li AM, Au CT.
Sleep Med. 2020 Dec;76:48-54. doi:10.1016/j.sleep.2020.09.024. Epub 2020 Oct 1. PMID: 33091726.
COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences.
Xie Q, Fan F, Fan XP, Wang XJ, Chen MJ, Zhong BL, Chiu HF.
Transl Psychiatry. 2020 Oct 2;10(1):337. doi:10.1038/s41398-020-01022-x. PMID: 33009366; PMCID: PMC7531059.
A randomised controlled trial of metacognitive training for psychosis, depression, and belief flexibility.
Ho-Wai So S, Hoi-Kei Chan G, Kit-Wa Wong C, Wing-Ka Ching E, Sze-Wai Lee S, Chi-Wing Wong B, Zhu C, Sun X, Kin-Hei Chung L, Hung AY, Oi-Yin Wong J, Sau-Man Chan S.
J Affect Disord. 2021 Jan 15;279:388-397. doi: 10.1016/j.jad.2020.09.126. Epub 2020 Oct 6. PMID: 33099054.
Prolonged visual fixation as a surrogate marker of cholinergic deficit in Parkinson’s disease: A 2-year follow-up study.
Wong OW, Chan A, Wong A, Lau CK, Yeung JH, Mok V, Chan S.
Parkinsonism Relat Disord. 2020 Dec;81:60-66. doi:10.1016/j.parkreldis.2020.10.019. Epub 2020 Oct 11. PMID: 33059183.
Higher Dementia Incidence in Older Adults with Poor Visual Acuity.
Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2162-2168. doi: 10.1093/gerona/glaa036. PMID: 32043518; PMCID: PMC7566398.
Benefit-Finding Intervention Delivered Individually to Alzheimer Family Caregivers: Longer-Term Outcomes of a Randomized Double-Blind Controlled Trial.
Cheng ST, Mak EPM, Kwok T, Fung H, Lam LCW.
J Gerontol B Psychol Sci Soc Sci. 2020 Oct 16;75(9):1884-1893. doi: 10.1093/geronb/gbz118. PMID: 31556447.
The Protective Effect of Daytime Sleep on Planning and Risk-Related Decision Making in Emerging Adults.
Wong ML, Lau EYY, Lam YC, Rusak B, Tseng CH, Lee TMC, Wing YK.
Soc Cogn Affect Neurosci. 2020 Oct 16;15(11):1228–37. doi:10.1093/scan/nsaa140. Epub ahead of print. PMID: 33064803; PMCID: PMC7745149.
Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
Neuropathol Appl Neurobiol. 2020 Oct 26. doi: 10.1111/nan.12673. Epub ahead of print. PMID: 33107057.
Mental health problems, needs, and service use among people living within and outside Wuhan during the COVID-19 epidemic in China.
Zhong BL, Zhou DY, He MF, Li Y, Li WT, Ng CH, Xiang YT, Chiu HF.
Ann Transl Med. 2020 Nov;8(21):1392. doi: 10.21037/atm-20-4145. PMID: 33313137; PMCID: PMC7723535.
Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
So SH, Mak AD, Chan PS, Lo CC, Na S, Leung MH, Ng IH, Chau AKC, Lee S.
J Affect Disord. 2021 Feb 15;281:949-957. doi:10.1016/j.jad.2020.11.019. Epub 2020 Nov 18. PMID: 33229019.
Letter to Editor.
Zhang C, Tang WK.
Psychiatry Res. 2021 Feb;296:113602. doi: 10.1016/j.psychres.2020.113602. Epub 2020 Nov 26. PMID: 33279254.
Behavioural dysexecutive syndrome after stroke: abridged secondary publication.
Tang WK, Wong KSL, Mok VCT, Chu CWW, Wang D, Wong A.
Hong Kong Med J. 2020 Dec;26 Suppl 6(6):30-33. PMID: 33229601.
Aerobic dance for cognitive and physical functions and mood in older adults with cerebral small vessel disease: abridged secondary publication.
Wong A, Mak MKY, Lam LCW, Mok VCT.
Hong Kong Med J. 2020 Dec;26 Suppl 6(6):38-41. PMID:33229603.
Home-based exercise intervention for caregivers of persons with dementia: a randomised controlled trial: abridged secondary publication.
Chan WC, Lam LCW, Lautenschlager N, Dow B, Ma SL.
Hong Kong Med J. 2020 Dec;26 Suppl 7(6):13-16. PMID: 33229611.
Management of Treatment-Resistant Depression in Real-World Clinical Practice Settings Across Asia.
Wang G, Han C, Liu CY, Chan S, Kato T, Tan W, Zhang L, Feng Y, Ng CH.
Neuropsychiatr Dis Treat. 2020 Dec 3;16:2943-2959. doi:10.2147/NDT.S264813. PMID: 33299316; PMCID: PMC7721287.
Definition and Identification of Patients with Treatment-Resistant Depression in Real-World Clinical Practice Settings Across Asia.
Han C, Wang G, Chan S, Kato T, Ng CH, Tan W, Zhang L, Feng Y, Liu CY.
Neuropsychiatr Dis Treat. 2020 Dec 3;16:2929-2941. doi: 10.2147/NDT.S264799. PMID: 33311981; PMCID: PMC7725069.
Mental health and psychological responses during the coronavirus disease 2019 (COVID-19) epidemic: A comparison between Wuhan and other areas in China.
Wang Q, Feng H, Wang M, Xie Y, Hou B, Lu X, Liu Z, Ouyang K, Zhang R, Cai Q, Xu Z, Li H, Chao H, Yang X, Hong Y, Hu X, Liu Z, Liu Y.
Psychosom Med. 2020 Dec 4. doi: 10.1097/PSY.0000000000000892. Epub ahead of print. PMID: 33284256.
THE BIDIRECTIONAL RELATIONSHIP BETWEEN VISION AND COGNITION: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Vu TA, Fenwick EK, Gan AT, Man RE, Tan BK, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee AT, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CL, Lamoureux EL.
Ophthalmology. 2020 Dec 14:S0161-6420(20)31158-1. doi: 10.1016/j.ophtha.2020.12.010. Epub ahead of print. PMID: 33333104.
Current Status of Tissue Clearing and the Path Forward in Neuroscience.
Zhao J, Lai HM, Qi Y, He D, Sun H.
ACS Chem Neurosci. 2021 Jan 6;12(1):5-29. doi: 10.1021/acschemneuro.0c00563. Epub 2020 Dec 16. PMID: 33326739.
The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.
Lui TK, Shum YH, Xiao XZ, Wang Y, Cheung AT, Chan SS, Neggers SFW, Tse CY.
Brain Stimul. 2021 Jan-Feb;14(1):161-169. doi: 10.1016/j.brs.2020.12.005. Epub 2020 Dec 17. PMID: 33346067.
Jan
CUHK-HKU Study Proves Bright Light Therapy as an Adjunctive Treatment Improves Outcomes in Depressed “Night Owl” Patients
Depression is among the most common mental health problems. About 1 in 10 adults in Hong Kong suffer from depressive symptoms. There is growing research suggesting a close relationship between mood disorders and the biological clock. “Night owls”, refers those who are late to bed and late to rise, are at greater risk of poor clinical outcomes with more sleep disturbances and depressive symptoms. The Department of Psychiatry of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), in collaboration with the Department of Psychology of the Faculty of Social Sciences at the University of Hong Kong (HKU), have conducted the world’s first randomised controlled trial of adjunctive bright light therapy for “night owls” with depression. Results showed bright light therapy doubles the probability of achieving remission, and the cumulative remission rate of depression reaches 67.4%. MORE
(From left) Dr. Shirley Li, Assistant Professor of the Department of Psychology, Faculty of Social Sciences at HKU; Professor Yun Kwok WING, Chairman and Dr. Joey Wing Yan CHAN, Associate Professor of the Department of Psychiatry at CU Medicine.
Jan
Findings of LANDSCAPE project gets published in the top journal of rehabilitation
Advanced Magnetic Resonance Imaging (MRI) analysis techniques have greatly contributed to detect the anatomical changes in age-related neurodegenerative diseases. With the fast development of transcranial brain stimulation, MRI-based morphometry is increasingly being applied to construct head model and optimize stimulation protocols. For years, converging evidence has accumulated on the clinical trials of brain stimulation, yet, the variability in morphometry limits the application and interpretation at individual level.
In a recent study of research team from the Neuromodulation Lab at the Department of Psychiatry, led by Research Assistant Professor Dr. LU Hanna, performed a study entitled “Localized Analysis of Normalized Distance from Scalp to Cortex and Personalized Evaluation (LANDSCAPE)”. Beyond age-related effects, we focused on ageing effect on region-specific cortical complexity and scalp-to-cortex distance (SCD). We found pronounced ageing effect on the SCD of left dorsolateral prefrontal cortex (DLPFC), not primary motor cortex (M1) in mild cognitive impairment (MCI) converters. The SCD change of left DLPFC from baseline to 3-year follow-up demonstrated better performance to discriminate MCI converters from normal ageing adults than the other morphometric features. The novel findings have been published in the Journal of NeuroEngineering and Rehabilitation (Rank: 2/115 in the field of Rehabilitation).
Significance of the study: The findings of this study have significant implications in morphometric imaging and precision medicine. Firstly, the identification of SCD in MCI converters that region-specific SCD may be used as a novel imaging biomarker for the early detection of dementia; meanwhile, offering valuable information to optimize the dosage of brain stimulation. Secondly, the newly developed method to quantify the SCD-related electric field changes (i.e., information entropy) may help to improve realistic head model, advancing precision medicine for neurodegenerative diseases in clinical trials (Figure 1).
Figure 1. Three-dimensional geometric simulation model of anodal transcranial current stimulation.
Article in Journal of NeuroEngineering and Rehabilitation
“Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling” by Hanna Lu, Jing Li, Li Zhang, Sandra Sau Man Chan and Linda Chiu Wa Lam & the Open Access Series of Imaging Studies (OASIS).
Link: https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-020-00764-5
Link to LANDSCAPE project: http://thebrainx.com/landscape/
LANDSCAPE project was supported by the Direct Grant of the Chinese University of Hong Kong (4054495).
Jan
Scientific and medical advancements are closely intertwined, psychiatry is no exception. The addition of neuroscience to the department is recent but well primed – guided by our strong track record in community and clinical psychiatry, neuroscience could broaden our scope in investigating psychiatric illness, it also brings novel perspectives in our understanding of clinical phenomena and paves the road to novel intervention and treatment. This completes our department’s multi-pronged approach aiming at easing the sufferings of those who are mentally ill.
With a highly diverse but cooperative departmental structure, we hope our joined forces would steer one step further towards relieving the burdens of psychiatric illness.
RESEARCHERS
Oct
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Nov
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