Professor
Room 360 Science Centre
(852) 3943 6165
(852) 2603 5057
jiangxia@cuhk.edu.hk
Education
| 1999 | B.Sc. | Nanjing University |
| 2002 | M.S. | Nanjing University |
| 2006 | Ph.D. | Stanford University |
Position
| Since 2021.8 | Professor, Department of Chemistry, The Chinese University of Hong Kong Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
| 2015.4-2021.7 | Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
| 2014.12-2021.7 | Associate Professor, Department of Chemistry, The Chinese University of Hong Kong |
| 2008.12-2014.12 | Assistant Professor, The Chinese University of Hong Kong |
| 2007-2008 | Research Associate, Howard Hughes Medical Institute |
| 2007-2008 | Postdoctoral scholar, California Institute of Technology |
Research Interests
Chemical biology, synthetic biology, and biomedicine
| 1. | New protein reactions, and the functionalization of proteins and therapeutic antibodies 新型生物交聯反應及蛋白和抗體的官能化 |
| 2. | Synthetic metabolons and organelles based on protein assembly technologies for cascade biocatalysis 基於蛋白質組裝的合成代謝結和細胞器 |
| 3. | Protein-based biomedicine for anti-bacterial infection and tissue regeneration 新型抗菌抑菌和組織再生材料 |
Our work focuses on the reaction, assembly, and engineering of proteins for chemical biology, synthetic biology, and biomedical applications. We have a focused interest in subcellular structures, such as organelles and protein coacervates, and their biocatalytic and biomedical applications.
Recent Publications
1 “Manganese Dioxide Nanozyme for Reactive Oxygen Therapy of Bacterial Infection and Wound Healing”
Liu, L.; Wang, C.; Li, Y.; Qiu, L.; Zhou, S.; Cui, P.; Jiang, P.; Ni, X.; Liu, R.; Du, X.; Wang, J.; Xia, J.* Biomaterials Science, 2021, DOI: 10.1039/D1BM00683E.
2 “Membrane-Permeable Antibacterial Enzyme against Multidrug-Resistant Acinetobacter baumannii”
Chen, X.; Liu, M.; Zhang, P.; Leung, S. S. Y.*; Xia, J.* ACS Infectious Diseases, 2021 doi: 10.1021/acsinfecdis.1c00222.
3 “Antimicrobial peptides towards clinical application: delivery and formulation”
Wang, C.; Hong, T.; Cui, P.; Wang, J.*; Xia, J.* Advanced Drug Delivery Review, 2021, 175, 113818.
4 “Antibacterial photodynamic gold nanoparticles for skin infection”
Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* ACS Applied Bio Materials 2021, 4, 3124–3132.
5 “Gelatinase-responsive release of antibacterial photodynamic peptide against Staphylococcus aureus”
Qiu, L.; Wang, C.; Lei, X.; Du, X.; Guo, Q.; Zhou, S.; Cui, P.; Hong, T.; Jiang, P.; Wang, J.*; Li, Y.*; Xia, J.* Biomaterial Sci. 2021, 9, 3433-3444.
6 “3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair” Huang, J.; Huang, Z.; Liang, Y.; Yuan, W.; Bian, L.; Duan, L.; Rong, Z.; Xiong, J.*; Wang, D.*; Xia, J.* Biomaterials Sci. 2021, DOI: 10.1039/D0BM02103B
7 “Non-surgical osteoarthritis therapy, intra-articular drug delivery toward clinical applications”
Liang Yujie, Xia, J.* J. Drug Targeting 2021, 1-16 (review)
8 “Engineering exosomes for targeted drug delivery”
Liang, Y.; Duan, L.; Lu, J.; Xia, J.* Theranostics 2021, 11, 3183-3195 (review)
9 “Exosome-mediated delivery of gene vectors for gene therapy”
Duan, L.; Xu, L.; Xu, X.; Qin, Z.; Zhou, X.; Xiao, Y.; Liang, Y.*; Xia, J.* Nanoscale 2021, 13, 1387-1397. (Review)
10 “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis”
Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* Curr. Med. Chem. 2020, DOI: 10.2174/0929867327666201118161232.
11 “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* Biomaterials 2020, 269, 120539.
12 “Antibacterial photodynamic peptides for staphylococcal skin infection”
Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* Biomater. Sci. 2020, 8, 6695-6702.
13 “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo”
Wei, Q.; He, S.; Qu, J.; Xia, J.* Bioconjugate Chem. 2020, 31, 2413-2420.
14 “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria”
Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. Int. J. Pharmaceutics 2020, 589, 119833
15 “Mesenchymal Stem Cell-Derived Exosomes for Treatment of Autism Spectrum Disorder”
Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* ACS Appl. Bio Mater. 2020, 3, 6384−6393.
16 “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy”
Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* ACS Appl. Mater. Interfaces 2020, 12, 36938–36947
17 “Host–guest protein assembly for affinity purification of methyl-lysine proteomes”
Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* Anal. Chem. 2020, 92, 9322-9329.
18 “Phase-separated multienzyme biosynthesis”
Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Biomacromolecules, 2020, 21, 2391-2399.
19 “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism”
Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268.
20 “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides”
So, W. H.; Xia, J.* Organic Lett. 2020, 22, 214-218.
21 “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds”
Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*. ACS Nano 2019, 13, 11343-11352.
22 “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux”
Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Nat. Commun. 2019, 10, 4248.
23 “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.”
Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.* ACS Nano 2019, 13, 9895-9906.
24 “Site-selective lysine reactions guided by protein-peptide interaction”
Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* Biochemistry 2019, 58, 1010-1018.
25 “Affinity purification of methyllysine proteome by site-specific covalent conjugation”
Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* Anal. Chem. 2018, 90, 13876-13881.
26 “Reverse binding mode of phosphotyrosine peptides with SH2 protein”
Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* Biochemistry 2018, 57, 5257-5269.
27 “Syntenin-targeted peptide blocker inhibits progression of cancer cells”
Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* Eur. J. Med. Chem. 2018, 154, 354-366.
28 “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction”
Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* Bioconjugate Chem., 2017, 28, 2199-2205.
29 “Site-selective covalent reactions on proteinogenic amino acids”
So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* Curr. Opin. Biotech. 2017, 48, 220–227 (Invited review).
30 “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells”
Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* Mol. Pharmaceutics 2017, 14, 1548−1557.
31 “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability”
Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* Chembiochem 2016, 17, 1416 – 1420.
32 “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition”
Yu, Y.; Xia, J.* Sci. China Chem. 2016, 59, 1-8 (Invited review)
33 “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis”
Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* ACS Chem. Biol. 2016, 11, 149-158.