Professor
Room 360 Science Centre
(852) 3943 6165
(852) 2603 5057
jiangxia@cuhk.edu.hk
Education
| 1999 | B.Sc. | Nanjing University |
| 2002 | M.S. | Nanjing University |
| 2006 | Ph.D. | Stanford University |
Position
| Since 2021.8 | Professor, Department of Chemistry, The Chinese University of Hong Kong |
| Since 2015.4 | Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
| 2014-2021 | Associate Professor, Department of Chemistry, The Chinese University of Hong Kong |
| 2008.12-2014.12 | Assistant Professor, The Chinese University of Hong Kong |
| 2007-2008 | Research Associate, Howard Hughes Medical Institute |
| 2007-2008 | Postdoctoral scholar, California Institute of Technology |
Research Interests
Chemical biology, synthetic biology and the applications in biomaterials and medicine
| 1. | Site-selective protein reactions: cysteine, tyrosine to lysine reactions; reactions of proteins, enzymes, antibodies to organelles |
| 2. | Designed protein assemblies: synthetic multienzyme complexes and synthetic organelles |
| 3. | Applications of protein-based biomaterials in regeneration and anti-infection |
Selected Publications
| 1. | “Host–guest protein assembly for affinity purification of methyl-lysine proteomes” Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* Anal. Chem. 2020. doi.org/10.1021/acs.analchem.0c01643 (Link) |
| 2. | “Phase-separated multienzyme biosynthesis” Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Biomacromolecules, 2020, doi.org/10.1021/acs.biomac.0c00321. (Link) |
| 3. | “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism” Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. (Link) |
| 4. | “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides” So, W. H.; Xia, J.* Organic Lett. 2020, 22, 214-218. (Link) |
| 5. | “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds” Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*. ACS Nano 2019, 13, 11343-11352. |
| 6. | “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux” Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Nat. Commun. 2019, 10, 4248. (Link) |
| 7. | “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.” Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.*. ACS Nano 2019, 13, 9895-9906. (Link) |
| 8. | “Magnetic enhancement of chondrogenic differentiation of mesenchymal stem cells” Huang, J.; Liang, Y.; Huang, Z.; Zhao, P.; Liang, Q.; Liu, Y.; Duan, L.; Liu, W.; Zhu, F.; Bian, L.; Xia, J.*, Xiong, J.;* Wang, D.* ACS Biomaterials Science & Engineering, 2019, 5, 2200-2207. (Link) [Featured on Supplementary Cover]. |
| 9. | “Site-selective lysine reactions guided by protein-peptide interaction” Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* Biochemistry. 2019, 58, 1010-1018. (Link) |
| 10. | “Affinity purification of methyllysine proteome by site-specific covalent conjugation” Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* Anal. Chem. 2018, 90, 13876-13881. (Link) [News report by Xmol] |
| 11. | “Reverse binding mode of phosphotyrosine peptides with SH2 protein” Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* Biochemistry 2018, 57, 5257-5269. (Link) |
| 12. | “Syntenin-targeted peptide blocker inhibits progression of cancer cells” Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* Eur. J. Med. Chem. 2018, 154, 354-366. (Link) |
| 13. | “A proximity-induced covalent fluorescent probe for selective detection of bromodomain 4” Feng, L.; Chhabra, M.; So, W. H.; Zhu, Q.; Xia, J.*; Sun, H.* Chin. Chem. Letters, 2018, 29, 1147-1150. (Link) |
| 14. | “Peptide photocaging: a brief account of the chemistry and biological applications” So, W. H.; Wong, C. T. T.; Xia, J.* Chin. Chem. Letters, 2018, 29, 1058-1062 (Invited review). (Link) |
| 15. | “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction” Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* Bioconjugate Chem., 2017, 28, 2199-2205. (Link) Selected as ACS Editor’s choice. Highlighted in the Facebook page and twitter of BC. |
| 16. | “Site-selective covalent reactions on proteinogenic amino acids” So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* Curr. Opin. Biotech. 2017, 48, 220–227 (Link) (Invited review). |
| 17. | “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells” Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* Mol. Pharmaceutics, 2017, 14, 1548−1557. (Link) |
| 18. | “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability” Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* Chembiochem, 2016, 17, 1416 – 1420. (Link) |
| 19. | “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition” Yu, Y.; Xia, J.* Sci. China Chem. 2016, 59, 1-8 (Invited review) (Link) |
| 20. | “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis” Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* ACS Chem. Biol. 2016, 11, 149-158. (Link) Selected representative work |
| 21. | “Site selective Azo coupling for peptide cyclization and affinity labeling of an SH3 protein.” Huang, F.; Nie, Y.; Ye, F.; Zhang, M.; Xia, J.* Bioconjugate Chem. 2015, 26, 1613-1622. |
| 22. | “Antiviral activities of whey proteins” Ng, T. B.; Cheung, R. C.; Wong, J. H.; Wang, Y.; Ip, D. T.; Wan, D. C.; Xia, J. Appl. Microbiol. Biotechnol. 2015, 99, 6997-7008. (Link) |