Professor Tak Wah Dominic CHAN（陳德華教授）

BSc (First Hons), PhD (University of Warwick, U.K.)
Professor

location Room 163 Science Centre
Phone No. (852) 3943 6260
Email (852) 2603 5057
Email twdchan@cuhk.edu.hk

 

 

 

 

 

 

 

 

 

 

 

Professional Activities

Since 2000 Member of the Editorial Advisory Board
1.European Journal of Mass Spectrometry
2.Journal of Chinese Mass Spectrometry Society
Since 1998 External Assessor for Grant Applications
1. HK Research Grants Council
2. HK Baptist University
3. Academic Sinica, Taiwan
Since 1998 Peer Reviewer for Research Papers
1. Journal of American Society for Mass Spectrometry
2. European Journal of Mass Spectrometry
3. Rapid Communication in Mass Spectrometry
4. Inorganic Chemistry Communication
5. Tetrahedron Letters
6. Carbohydrate Research
Since 1998 Member of American Society for Mass Spectrometry
Since 1998 Member of British Mass Spectrometry Society
2021 Member of the Australian and New Zealand Society for Mass Spectrometry
2008-2019 Member of the Editorial Advisory Board
Rapid Communication in Mass Spectrometry Society
2007-2012 Member of the Editorial Advisory Board
Journal of American Society for Mass Spectrometry
2006 Organiser of the 4th International Uppsala Conference on Electron Capture and Dissociation Mass Spectrometry — Fundamental and Applications
2005, 2000-2001 President-Hong Kong Society for Mass Spectrometry (HKSMS)
1999 Vice president-Hong Kong Society for Mass Spectrometry (HKSMS)
1998 Founding Member–Hong Kong Society for Mass Spectrometry (HKSMS)
1998 Chief Examiner of the HK A-Level Chemistry Examination, Hong Kong Examination Authority
1998 Organizer of two-week Training Workshop on Mass Spectrometry and State-of-the-Art Mass Spectrometry Instruments for PRC Young Scientists
1995-2000 Member of the Chemistry Subject Committee, Certificate of Education Examination, Hong Kong Examination Authority

 

Honours and Awards

2019 First Class Award, China Association for Instrumental Analysis
2016 First Class Award, China Association for Instrumental Analysis
2011 Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong
2002 Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong
1989-1992 PhD Scholarship, Shell Thomton Research Centre, UK
1989-1992 Overseas Research Student Award, Committee of Vice-Chancellors and Principals of the UK Universities, UK

 

Research Interests

1. Development of mass spectrometry-based methodologies for characterization of peptides/ proteins, DNA fragments and carbohydrates
2. Development of novel ionization methods and mass spectrometry interfaces for biomolecule analysis
3. Development of high resolution two-dimensional imaging system based on membrane funnel-based spray ionization mass spectrometry
4. Development of differential ion mobility spectrometer based tandem devices for selected ion-molecule reactions prior to mass spectrometry analysis

 

 

Research Grants/Funding

Total Amount (HKD 16.85 million)

2019 Faculty Development Scheme, University Grants Council, HKSAR
2018 Direct Grants, The Chinese University of Hong Kong
2017 Direct Grants, The Chinese University of Hong Kong
2016 Earmarked Grants Research Grants Council, HKSAR
2015 Direct Grants, The Chinese University of Hong Kong
2009 Earmarked Grants Research Grants Council, HKSAR
2008 Direct Grants, The Chinese University of Hong Kong
2007 Earmarked Grants Research Grants Council, HKSAR
2006 Direct Grants, The Chinese University of Hong Kong
2006 K.C. Wong Education Foundation
2006 Sponsorship of International Conference
The Croucher Foundation
2006 Earmarked Grants Research Grants Council, HKSAR
2004 Earmarked Grants Research Grants Council, HKSAR
2003 Earmarked Grants Research Grants Council, HKSAR
2002 Summer Research Grants, The Chinese University of Hong Kong
2002 Special Equipment Grants, The Chinese University of Hong Kong
2002 Direct Grants, The Chinese University of Hong Kong
2000 Earmarked Grants Research Grants Council, HKSAR
1998 Earmarked Grants Research Grants Council, HKSAR
1997 Direct Grants, The Chinese University of Hong Kong
1997 Joint HK/UK Research Scheme, British Council
1997 Lee Hysan Foundation Fund
1997 One-time Support Funded Projects, The Chinese University of Hong Kong
1996 Earmarked Grants Research Grants Council, HKSAR
1995 Earmarked Grants Research Grants Council, HKSAR
1995 Direct Grants, The Chinese University of Hong Kong
1994 Direct Grants, The Chinese University of Hong Kong

 

Patents

2018 An authentication method for ginsengs based on differential ion mobility spectrometry mass spectrometry (DMS-MS)
Approved, reference no. ZL201811100590.X)

Research Collaborations

1. University of Washington, Seattle, USA
2. Uppsala University, Sweden
3. University of Warwick, United Kingdom
4. Chinese Academy of Sciences, PRC
5. Peking University, PRC
6. Tsinghua University, PRC
7. Hong Kong University of Science & Technology, Hong Kong
8. Institute of Chinese Medicine, The Chinese University of Hong Kong
9. Faculty of Medicine, The Chinese University of Hong Kong
10. New Beta Innovation, Hong Kong

 

Publications

1. “Development of a Matrix Sublimation Device with Controllable Crystallization Temperature for MALDI Mass Spectrometry Imaging” H. Xie, R. Wu, Y.L.W. Hung, X. Chen, T.-W. D. Chan, Anal. Chem., 2021, accepted.
2. “Development of an All-in-One Protein Digestion Platform Using Sorbent-Attached Membrane Funnel-Based Spray Ionization Mass Spectrometry”, Y.L.W. Hung, X. Chen, Y.L. E. Wong, R. Wu, T.-W. D. Chan, J. Am Soc. Mass Spectrom., 2020, 34, 1-5.
3. “Fine Adjustment of Gas Modifier Loadings for Separation of Epimeric Glycopeptides Using Differential Ion Mobility Spectrometry Mass Spectrometry”, R. Wu, X. Chen, W. J. Wu, Y.-L. W. Hung, H. T. Wong, T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2020, 34, 1-5.
4. “Differentiation of Asian and American Ginseng by Differential Ion Mobility Spectrometry – Tandem Mass Spectrometry Using Stepwise Modulation of Gas Modifier Concentration”, R. Wu, X. Chen, W. J. Wu, Z. Wang, Y.-L. E. Wong, Y.-L. W. Hung, H. T. Wong, T.-W. D. Chan, J. Am Soc. Mass Spectrom., 2019, 30, 2212-2221.
5. “Electron-ion Reaction Based Dissociation: A Powerful Ion Activation Method for Natural Product Structure Elucidation”, X. Chen, Y.-L. E. Wong, Z. Wang, R. Wu, Y.-L. W. Hung, T.-W. D. Chan, Mass Spectrom. Rev., 2018, 37(6), 793-810.
6. “Performance Enhancements in Differential Ion Mobility Spectrometry-Mass Spectrometry (DMS-MS) by Using a Modified CaptiveSpray Source”, R. Wu, W. J. Wu, Z. Wang, Y.-L. E. Wong, Y.-L. W. Hung, H. T. Wong, X. Chen, T.-W. D. Chan, J. Am Soc. Mass Spectrom., 2018, 29, 2199-2207.
7. “Optimization of protein extraction and two-dimensional gel electrophoresis profiles for the identification of Cordyceps sinensis and other similar species”, R. C. H. Chan, S. S. W. Lam, F. L. Y. Fong, D. T.-W. Chan, F. W. F. Lee and E. T. P. Sze, Plos One, 2018.
8. “Tissue Imaging with in situ Solid-Phase Extraction Micro-funnel Based Spray Ionization Mass Spectrometry”, W. Li, X. Chen, Z. Wang, Y.-L. E. Wong, R. Wu, Y. W. Hung, T.-W. D. Chan, Eur. J. Mass Spectrom., 2018, 24, 66.
9. “Structural Characterization of Intact Glycoconjugates by Tandem Mass Spectrometry Using Electron-Induced Dissociation”, Y.-L. E. Wong, X. Chen, R. Wu, Y.-L. W. Hung, and T.-W. D. Chan, Anal. Chem. 2017, 89, 10111.
10. “Generation and Characterization of Gas-Phase Doubly Charged Peptide Ions (M2+··)” Y. -L. E. Wong, X. Chen, R. Wu, Y. L. W. Hung, H. S. Yeung and T.-W. D. Chan, Anal. Chem. 2017, 89, 7773.
11. “Metal-Organic Framework@Microporous Organic Network as Adsorbent for Solid-Phase Microextraction” Y. Jia, H. Su, Z. Wang, Y.-L. E. Wong, X. Chen, M. Wang, T.-W. D. Chan Anal. Chem., 2016, 88, 9364-9367.
12. “Differentiation of Isomeric Ginsenosides by using Electron Induced Dissociation Mass Spectrometry” Y. L. E. Wong, X. Chen, Z. Wang, W. Li, Y. L. W. Hung, R. Wu, and T.-W. D. Chan, Anal. Chem. 2016, 88, 5590-5594.
13. “Hexagonal Boron Nitride Nanosheets as Adsorbent for Solid-Phase Extraction” S. Jia, Z. Wang, N. Ding, Y.-L. E. Wong, X. Chen, G. Qiu, T. W. D. Chan Anal. Chim. Acta,  2016, 936, 123-129.
14. “C18-attached Membrane Funnel-based Spray Ionization Mass Spectrometry for Quantification of Anti-diabetic Drug from Human Plasma”, W. Li, X. Chen, Y. L. E. Wong, Y. L. W. Hung, Z. Wang, L. Deng, T.-W. D. Chan, Anal. Chim. Acta, 2016, 933, 97-102.
15. “Thermo-Responsive Polymer Tethered Metal-Organic Framework Core-Shell Magnetic Microspheres for Magnetic Solid-Phase Extraction of Alkylphenols from Environmental Water Samples” Y. Jia, H. Su, Y. L. E. Wong, X. Chen, T. W. D. Chan, J. of Chrom. A 2016, 1456, 42-48.
16. “Dissociation of Trivalent Metal Ion (Al3+, Ga3+, In3+ and Rh3+)-Peptide Complex Under Electron Capture Conditions” X. Chen, G. Liu, Y. L. E. Wong, L. Deng, Z. Wang, W. Li, T.-W. D. Chan, Rapid Comm. Mass Spectrom. 2016, 30, 705-710.
17. “Sensitivity and Robustness Enhancements by using V-Shape Ion Funnel in FTICR-MS”, L. Deng, X. Chen, W. Li, Z. Wang, Y. L.E. Wong and T-W. D. Chan, Anal. Chem., 2015, 87, 8073-8077.
18. “Development of Miniaturized Sorbent Membrane Funnel-Based Spray Platform for Biological Analysis”, H. S. Yeung, X. Chen, W. Li, Z. Wang, Y. L. E. Wong, and T.-W. D. Chan, Anal. Chem., 2015, 87, 3149-3153.
19. “A cadmium(II)-based metal-organic framework material for the dispersive solid-phase extraction of polybrominated diphenyl ethers in environmental water samples”, H. Su, Z. Wang, Y. Jia, L. Deng, X. Chen, T.-W. D. Chan, J. Chromatography A, 2015, 1422, 334-339.
20. “Suppression of Peptide Ion Dissociation under Electron Capture: Role of Backbone Amide Hydrogen”, P.-S. J. Wong, X. Chen, L. Deng, Z. Wang, W. Li, Y. L. E. Wong and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2015, 29, 1-8.
21. “Membrane Funnel-Based Spray Ionization for Protein/Peptide Analysis by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, H. S. Yeung, W. Li, Z. Wang, Y. L. E. Wong, X. Chen and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2015, 29, 336-342.
22. “Evaluation and Comparison of Collision Induced Dissociation and Electron Capture Dissociation for Top Down Analysis of Intact Ribonuclease B”, Z. Wang, X. Chen, L. Deng, W. Li, Y. L. E. Wong, and T.-W. D. Chan, Euro. J. Mass Spectrom., 2015, 21, 707-711.
23. “Effect of Structural Parameters on the ECD and CID Pathways of Cu(II)-Peptide Complexes”, X. Chen, Z. Wang, W. Li, Y. L. E. Wong and T.-W. D. Chan, Euro. J. Mass Spectrom., 2015, 21, 649-657.
24. “Fe3O4@MOF core-shell magnetic microspheres for magnetic solid-phase extraction of polychlorinated biphenyls from environmental water samples”, X. Chen, N. Ding, H. Zang, H. S. Yeung, R. Zhao, C. Cheng, J. Liu, T.-W. D. Chan, J. Chromatography A, 2013, 1304, 241-245.
25. “Reaction pathways of Sc+ (3D, 1D) and Fe+ (6D, 4F) with acetone in the gas phase: metal ion oxidation and acetone deethanization”, X. Chen, H. Zang, H. S. Yeung, X. Lu, T.-W. D. Chan, J. Mass Spectrom., 2012, 47, 1218-1525.
26. “Transition Metal Ions: Charge Carriers that Mediate the Electron Capture Dissociation Pathways of Peptides” X. Chen, Y. M. E. Fung, W. Y. K. Chan, P. S. Wong, H. S. Yeung, T.-W. D. Chan, J. Am Soc. Mass Spectrom., 2011, 22, 2232-2245.
27. “Formation of Peptide Radical Cations (M+·) in Electron Capture Dissociation of Peptides Adducted with Group IIB Metal Ions” X. Chen, W. Y. K. Chan, P. S. Wong, H. S. Yeung, T. W. D. Chan, J. Am. Soc. Mass Spectrom., 2011, 22, 233.
28. “Natural structural motifs that suppress peptide ion fragmentation after electron capture”, W. Y. K. Chan and T.-W. D. Chan, J. Am. Soc. Mass Spectrom., 2010, 21, 1235.
29. “Electron transfer dissociation with supplemental activation to differentiate aspartic and isoaspartic residues in doubly charged peptide cations” , W. Y. K. Chan, T.W. D. Chan and P. B. O’Connor, J. Am. Soc. Mass Spectrom., 2010, 21, 1012.
30. “A Mechanistic Study of the Electron Capture Dissociation of Oligonucleotides, T.-W.D. Chan, M.F. Choy, W.Y.K. Chan, Y.M.E. Fung,  J. Am. Soc. Mass Spectrom., 2009, 20, 213.
31. “Stimulation of histamine H2 receptors activates TRPC3 channels through both phospholipase C and phospholipase D, H-Y Kwan, C-O Wong, Z. Yu, T-W. Chan, Y. Huang, X. Yao, Euro, J. Pharmacology, 2009, 602, 181.
32. “Determination of molecular weight profile for a bioactive b-(1→3) polysaccharides (curdlan)”, T.-W. D. Chan, P.K. Chan and K.Y. Tang, Anal. Chim. Acta, 2006, 556, 226.
33. “Electron Capture Dissociation of Peptides Metalated with Alkaline-Earth Metal Ions”, Y. M. E. Fung,  H. Liu  and T.-W. D. Chan, J. Am. Soc. Mass Spectrom., 2006, 17, 757 – 771.
34. “Analyses of Stemona Alkaloids in Stemona Tuberosa by Liquid Chromatography / Tandem Mass Spectrometry, Y. Zhou, R. Jiang, P. Hon, Y. Xu, Y. Chan, T-W. D. Chan, H. Xu, L. Ding, P. P. But, P. Shaw, Rapid Commun. Mass Spectrom., 2006, 20, 1030.
35. “Facile disulfide bond cleavage in gaseous peptide and protein cations by 157-nm ultra-violet photo-dissociation”, Y. M. E. Fung, F. Kjeldsen, O. A. Silivra, T.-W. D. Chan and R. A. Zubarev, Angew. Chem. Int. Ed., 2005, 44, 2.
36. “Experimental and theoretical investigations of the loss of amino acid side chains in electron capture dissociation of model peptides”, Y. M. E. Fung and T.-W. D. Chan, J. Am. Soc. Mass Spectrom., 2005, 16, 1523.
37. “A modified internal lock-mass method for calibration of the product ions derived from sustained off-resonance irradiation collision-induced dissociation (SORI-CID) using a Fourier transform mass spectrometer (FTMS)” L. Duan and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2004, 18, 1286.
38. “A comparative study of the collision induced dissociation and the electron capture dissociation of model peptides using ESI-FTMS” Y.M.E. Fung, L. Duan and T.-W. D. Chan, Euro. J. Mass Spectrom., 2004, 10, 449.
39. “Analysis of a bioactive β-(1→3) polysaccharide (Curdlan) by using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOFMS)” T.-W.D. Chan and K. Y. Tang, Rapid Commun. Mass Spectrom., 2003, 17, 1.
40. “Accurate mass measurements for peptide and protein mixtures by using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)”, T.-W. D. Chan, L. Duan and T.-P. E. Sze, Anal. Chem., 2002, 74, 5282.
41. “Optimization of Experimental Parameters for Electron Capture Dissociation of Peptides in a Fourier Transform Mass Spectrometer (FTMS)”, T.-W.D. Chan and W.H.H. Ip, J. Am. Soc. Mass Spectrom., 2002, 13, 1396.
42. “A study of fast and metastable dissociations of adenine-thymine binary-based oligonucleotides by using positive-ion MALDI-TOF mass spectrometry”, T.-W. D. Chan, Y. M.E. Fung and Y. C. L. Li, J. Am. Soc. Mass Spectrom., 2002, 13, 1052.
43. “Tetrapyrrole derivatives substituted with ferrocenylethynyl moieties. Synthesis and Electrochemical studies”, K-W. Poon, W. Liu, P-K. Chan. Q. Yang, T-W. D. Chan, T.C.W. Mak and D.K.P. Ng, J. Org. Chem., 2001, 66, 1553.
44. “Antioxidative Glucosides from the fruits of Ligustrum lucidium”, Z-D. He, P.P-H. But, T-W.D. Chan, H. Dong, H-X. Xu, C-P. Lau and H-D. Sun, Chem. Pharm. Bull, 2001, 49, 780.
45. “Sequence analysis of peptides with biological activities using electrospray-Fourier transform ion cyclotron resonance mass spectrometry”, M. He, J. Xu, T-W. D. Chan and R.L.C. Lau, Chinese Science Bulletin, 2001, 46, 1281.
46. “Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS”, T-W.D. Chan, P.P.H. But, S.W. Cheng, I.M.Y. Kwok, F.W. Lau and H.X. Xu, Anal. Chem., 2000, 72, 1281.
47. “Synthesis and structural characterization of highly chlorinated, brominated, iodinated, and methylated carbroane anions, H-1-CB9X9–, NH2-1-CB9X9– (X = Cl, Br, I), and H-1-CB9(CH3)9–“, C. W. Tsang, Q. Yang, E. T. Sze, T. C. Mak,  T.W. D. Chan, Z. Xie, Inorg. Chem., 2000, 39, 3582.
48. “Weakly coordinating nature of a carborane cage bearing different halogen atoms. Synthesis and structural characterization of icosahedral mixed halocarborane anions, 1-H-CB11Y5X6– (X, Y = Cl, Br, I)”, C. W. Tsang, Q. Yang, E. T. Sze, T. C. Mak, T.-W. D. Chan, Z. Xie, Inorg. Chem., 2000, 39, 5851.
49. “Effect of sample preparation methods on the analysis of dispersed polysaccharides by MALDI-TOF mass spectrometry, Rapid Commun. Mass Spectrom., 2000, 14, 1841.
50. “Differentiation of enantiomers by using matrix-assisted laser desroption / ionization (MALDI) mass spectrometry”, M.P. So, T.S.M. Wan and T-W.D. Chan, Rapid Commun. Mass Spectrom., 2000, 14, 692.
51. “A novel non-metallized tip for electrospray mass spectrometry at nanoliter flow rate”, K.W.Y. Fong and T-W.D. Chan, J. Am. Soc. Mass Spectrom., 1999, 10, 72.
52. “Time-of-flight effects in matrix-assisted laser desorption / ionization Fourier transform mass spectrometry”, E.T-P. Sze and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1999, 13, 398-406.
53. “Highly Chlorinated, brominated, and iodinated icosahedral carbonane anions: 1-H-CB11X11–, 1-CH3-CB11-X11– (X = Cl, Br, I); 1-Br-CB11B11–“, Z. Xie, C-W. Tsang, E.T-P. Sze, Q. Yang, T-W.D Chan and T.C.W. Mak, Inorg. Chem., 1998, 37, 6444.
54. “Formulation of matrix solutions for use in matrix-assisted laser desorption/ionization (MALDI) of Biomoelcules”, E.T.P. Sze, G. Wang and T-W.D. Chan; J. Am. Soc. Mass Spectrom., 1998, 9, 166-174.
55. “Evaluation of ammonium salts as co-matrices for matrix-assisted laser desorption / ionization mass spectrometry of oligonucleotides”, Y.C.L. Li, S-W. Cheng and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1998, 12, 993.
56. “Origins of proton in the generation of ions from polymers and peptides in matrix-assisted laser desorption / ionization”, C.K.L. Wong, M.P. So and T-W.D. Chan; Euro. Mass Spectrom., 1998, 4, 223.
57. “Fourier transform ion cyclotron resonance studies of Lanthanide(III) porphyrin-phthalocyanine heteroleptic sandwich complexes using electrospray ionization”, R.L.C. Lau, J.Jiang, D.K.P. Ng and T-W.D. Chan; J. Am. Soc. Mass Spectrom., 1997, 8, 161-169.
58. “Sesquterpene lactones from Elephantopus scaber”, P.P-H. But, P-M.Hon, T-W.D. Chan, T.C.W. Mak and C-T. Che; Phytochemistry, 1997, 44, 113-116.
59. Synthesis, spectroscopic and electrochemical properties of substituted bis(phthalocyaninato)lanthanide(III) complexes”, J. Jiang, R.C.W. Liu, T.C.W. Mak, T-W.D. Chan and D.K.P. Ng, Polyhedron, 1997, 16, 515-520.
60. “Synthesis and spectroscopic properties of heteroleptic sandwich-type (phthalocyaninato)(porphyrinato)lanthanide(III) complexes”, J. Jiang, R.L.C. Lau, T-W.D. Chan, T.C.W. Mak and D.K.P. Ng; Inorg. Chim Acta, 1997, 255, 59-64.
61. “Cationization processes in matrix-assisted laser desorption/ionization mass spectrometry : Attachment of divalent and trivalent metal ions” C.K.L. Wong and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1997, 11, 513-519.
62. “Mass spectra of hydrazo, azo and azoxy compound”, T-W.D. Chan and S.W. Tam, in The Chemistry of Hydrazo, Azo and Azoxy Groups, vol. 2, edited by S. Patai, John Wiley, & Sons Ltd., Chichester, 1997, Ch. 4, 105-135.
63. “Dendritic models of redox proteins: X-ray photoelectron spectroscopy and cyclic voltammetry studies of dendritic bis(terpyridine) iron(II) complexes”, H-F Chow, Y-K. I Chan, T-W. D Chan and R.W.M. Kwok; Chem. Eur. J., 1996, 2, 133.
64. “Use of ammonium halides as co-matrices for matrix-assisted laser desorption / ionization studies of oligonucleotides”, S-W. Cheng and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1996, 10, 907-910.
65. “Positive-ion electrospray mass spectra for a number of polypeptides and proteins”, M. He, J. Xu, T-W.D. Chan and R.L.C. Lau; Rapid Commun. Mass Spectrom., 1996, 10, 987-902.
66. Fourier transform ion cyclotron resonances studies of terpyridine-based polyether dendrimers and their iron(II) metallocomplexes by liquid secondary ion mass spectrometry”, R.L.C. Lau, T-W. D. Chan, I.Y-K. Chan and H.F. Chow; Euro. Mass Spectrom., 1995, 1, 371-380.
67. Design considerations in energy resolved time-of-flight mass spectrometry”, A.E. Giannakopulos, D.J. Reynolds, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. Ion Phys., 1994, 131, 67.
68. “Initial velocities of positive and negative protein molecule-ions produced in matrix-assisted ultraviolet laser desorption using a liquid matrix”, T-W.D. Chan, I. Thomas, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1994, 222, 579.
69. “Threshold fluences for production of positive and negative ions in matrix-assisted laser desorption / ionisation using liquid and solid matrices”, P.Y. Yau, T-W. D. Chan, P.G. Cullis, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1993, 202, 93.
70. “Suppression of matrix-ions in ultraviolet laser desorption: Scanning electron microscopy and Raman spectroscopy of the solid sample”, T-W.D. Chan, A.W. Colburn, P.J. Derrick, D.J. Derek and M. Bowden; Org. Mass Spectrom., 1992, 27, 188.
71. “Matrix-assisted laser desorption / ionization using a liquid matrix: Formation of high-mass cluster ions from proteins”, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1992, 27, 53.
72. “Computer-controlled activation of 25µm diameter tungsten wire for field desorption”, T-W. D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. and Ion Phys., 1991, 107, 491.
73. “Matrix-assisted ultraviolet laser desorption: Suppression of the matrix peaks”, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1991, 26, 342.