School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

龐佑信教授

PONOMAREV Eugene D

研究助理教授

B.S., M.S., Ph.D.

電話:  3943 9620

電郵:  Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它

地址:

 Room 323A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, The Chinese University of Hong Kong

 Website:  https://scholar.google.com/citations?user=SZDQ_oQAAAAJ&hl=en/citations?user=0jvjVzQAAAAJ&hl=en

Publons: https://publons.com/researcher/2607543/eugene-d-ponomarev/

ORCID: https://orcid.org/0000-0002-0871-8522

 

 

 

個人簡介

Prof. PONOMAREV Eugene (龐佑信) is currently appointed to the School of Biomedical Sciences, The Chinese University of Hong Kong, and his research interest is related to the immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury.  Particularly he is interested in (1) epigenetic and transcriptional control of microglia/macrophage activation during CNS inflammation and (2) the role of platelets in the initiation of neuroinflammation.  Both directions of his research program are currently supported by RGC and HMRF grants.  Dr. Ponomarev is well known scientist in field of neuroinflammation and neurodegeneration and he is an author of more than 40 publications in top academic journals such as Nature Medicine, Journal of Immunology, Journal of Neuroscience, Brain, Behavior and Immunity, Frontiers in Immunology, and Circulation Research.  Dr. Ponomarev serves in the editorial boards of number of International academic journals such as Immunology & Cell Biology, Journal of Immunology, Journal of Neuroscience, Journal of Clinical Immunology, Annals of Neurology, Journal of Neuroinflammation, PLoS One, EMBO Reports etc.  Before his relocation to Hong Kong, Eugene Ponomarev spent 12 years in the USA working as a scientist in top academic institutions such as Brigham and Women’s Hospital, Harvard Medical School (Boston) where he held the position of Assistant Professor and his work was supported by RO1 grant form National Institute of Health.

  1. Immunological aspects of inflammation in the central nervous system (CNS) associated with neurodegenerative disease such as multiple sclerosis, Alzheimer’s disease and traumatic brain injury.
  2. Epigenetic and transcriptional control of microglia/macrophage activation during CNS inflammation.
  3. The role of platelets in the initiation and propagation of neuroinflammation.
  1. Kopeikina, E., Dukhinova, M., Yung, A.W.Y., Veremeyko, T., Kuznetsova, I.S., Lau, T.Y.B., Levchuk, K., & Ponomarev, E.D. (2020). Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress. Prog Neurobiol., 188: 101783. doi: 10.1016/j.pneurobio.2020.101783.
  2. Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Strekalova, T. & Ponomarev, E.D. (2019). The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System. Frontiers in Cellular Neuroscience, 13, 453. doi: 10.3389/fncel.2019.00453.
  3. Dukhinova, M., Veremeyko, T., Yung, A.W.Y., Kuznetsova, I.S., Lau, T.Y.B., Kopeikina, E., Chan, A.M.L. & Ponomarev, E.D. (2019). Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease. Neurobiol Aging, 77, 128-143. doi: 10.1016/j.neurobiolaging.2019.01.020.
  4. Veremeyko, T., Kuznetsova, I.S., Dukhinova, M., Yung, A.W.Y., Kopeikina, E., Barteneva, N.S. & Ponomarev E.D. (2019). Neuronal Extracellular MicroRNAs miR-124 and miR-9 Mediate Cell-Cell Communication between Neurons and Microglia. J Neurosci Res., 97 (2): 162-184. doi: 10.1002/jnr.24344.
  5. Veremeyko, T., Yung, A.W.Y., Anthony, D.C., Strekalova, T. & Ponomarev E.D. (2018) Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription factor CEBPβ. Frontiers in Immunology, doi: 10.3389/fimmu.2018.02515.
  6. Dukhinova, M., Kuznetsova, I., Kopeikina, E., Veniaminova, E., Yung, A.W.Y., Veremeyko, T., Levchuk, K., Barteneva, N.S., Wing-Ho, K.K., Yung, W.H., Liu, J.Y.H., Rudd, J., Yau, S.S.Y., Anthony, D.C, Strekalova, T. & Ponomarev E.D. (2018). Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury. Brain Behav Immun., 74: 7-27. doi: 10.1016/j.bbi.2018.09.009.
  7. Veremeyko, T., Yung, A.W.Y., Dukhinova, M., Kuznetsova, I.S., Pomytkin, I., Lyundup, A., Strekalova, T., Barteneva, N. & Ponomarev E.D. ((2018). Cyclic AMP pathway suppress autoimmune neuroinflammation by inhibiting functions of encephalitogenic CD4 T cells and enhancing M2 macrophage polarization at the site of inflammation. Frontiers in Immunology., doi: 10.3389/fimmu.2018.00050.
  8. Pomytkin, I., Costa-Nunes, J.P., Kasatkin, V., Veniaminova, E., Demchenko, A., Lyundup, A., Lesh, K.P., Ponomarev E.D.* & Strekalova T. (2018). Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment. CNS Neuroscience & Therapeutics, 24 (9): 763-774. doi: 10.1111/cns. (*co-corresponding author).
  9. Ponomarev E.D. (2018). Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation, and deactivation of Th1, Th17 and Tregs during tissue inflammation. Frontiers in Immunology, doi: 10.3389/fimmu.2018.00406.
  10. Kopeikina, E., Dukhinova, M. & Ponomarev, E.D. ((2018). Methods of Study of Neuron Structural Heterogeneity: Flow Cytometry vs. Laser Interferometry. Methods Mol Biol., 1745:155-166. doi: 10.1007/978-1-4939-7680-5_9.
  11. Dukhinova, M., Kopeikina, E. & Ponomarev E.D. (2018). Usage of Multiparameter Flow Cytometry to Study Microglia and Macrophage Heterogeneity in the Central Nervous System During Neuroinflammation and Neurodegeneration. Methods Mol Biol., 1745:167-177. doi: 10.1007/978-1-4939-7680-5_10.
  12. Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y., Weiner, H.L. & Ponomarev E.D. (2015). Platelets Play Differential Role in the Regulation of the Initiation and Progression of Autoimmune Neuroinflammation. Circulation Research, 117 (9): 779-792.
  13. Starossom, S.C., Veremeyko, T., Dukhinova, M., Yung, A.W.Y. & Ponomarev E.D. (2014). Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: possible role of Copaxone in targeting platelets during autoimmune neuroinflammation. PLOS ONE, 9 (5): e96256.
  14. Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A.W.Y. & Ponomarev E.D. (2013). IL-4/IL-13-Dependent and Independent Expression of miR-124 and its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and During Allergic Inflammation. PLOS ONE, 8(12): e81774.
  15. Sotnikov, I., Vermeyko, T., Starossom, S.C., Barteneva, N., Weiner H.L. & Ponomarev E.D. (2013). Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLOS ONE, 8 (3): e58979.
  16. Veremeyko, T., Starossom, S.C., Weiner, H.L. & Ponomarev E.D. (2012). Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J. Vis. Exp., 65: 10.3791/4097.
  1. RGC - General Research Fund [PI; 01-Sep-16 to 31-Aug-19]: "The Role of Interactions of Platelets with Brain-specific Neuronal Glycolipids in the Regulation of Neuroinflammation and Modulation of Neuronal Functions during Neurological Disorders" (HK$1,072,550).
  2. Health and Medical Research Fund [PI; 01-Mar-15 to 28-Feb-17]: "Role of Platelet-T Cell Interactions in Pathogenesis of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)" (HK$785,000).
  3. RGC - General Research Fund ECS [PI; 01-Jul-14 to 30-Jun-17]: "The Role of microRNA-124 in Transcriptional Control of Macrophage Polarization and Suppression of Neuroinflammation" (HK$671,175).