School of Biomedical Sciences
生物醫學學院
The Chinese University of Hong Kong 香港中文大學

Prof. JIANG Yangzi


JIANG Yangzi1Research Assistant Professor of the Institute for Tissue Engineering and Regenerative Medicine

 

Telephone:   3943 5153

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Address:

Room 421A, 4/F, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Website:  https://www.iterm.cuhk.edu.hk/our-people/prof-jiang-yangzi/

Publons: https://publons.com/researcher/1854631/yangzi-jiang/

ORCID: https://orcid.org/0000-0002-7475-3182

 

 

Biography

Prof. JIANG Yangzi (姜洋子) received Bachelor (2007, Biology) and PhD (2012, Sports Medicine) in Zhejiang University, China, and received her postdoctoral training (2012-2018) at University of Pittsburgh, USA. Prof. Jiang joined CUHK in 2018 as Research Assistant Professor at institute for Tissue Engineering and Regenerative Medicine (iTERM), School of Biomedical Sciences (SBS), and Assistant Professor (by courtesy) at Department of Orthopaedics & Traumatology (ORT). 

 

Prof. Jiang has extensive multi-discipline expertise in basic scientific research, medical translational research and education in stem cells and regenerative medicine, particularly in bone and cartilage regeneration. She has contributed to both textbooks and industrial guidelines to the field of Tissue Engineering and Regenerative Medicine, and her mentored students had been awarded with scholarships, research grants and honors from different universities, states and countries (China, Australia, and United States).  Prof. Jiang’s previous research work has focused on creating tissue regeneration strategies of musculoskeletal system, particularly in bone and cartilage. Her publications cover the topics of stem cells, tissue engineering, cell transplantation, biomaterials, pathology of osteoarthritis, and translational medicine.  Prof. Jiang has sought to understand the stem/progenitor cell origin (Nat Rev Rheum, 2015) and signaling pathways (Arthritis Res Ther, 2015) of human articular cartilage in both healthy and disease conditions, and apply these knowledges to instruct the production of functional tissue replacements for clinical use.   Prof. Jiang’s work of taking the cartilage derived stem/progenitor cells for repair large-size of osteochondral defect (6-13 cm2, ave 8.5 cm2) in 15 young patients (Stem Cells Transl Med, 2016) has also paved a way for the autologous cell-based Tissue Engineering Techniques as Class III Therapeutics in China (J Ortho Transl, 2014), and many patients had been benefited. 

 

In 2019, Prof. Jiang led the first team in Hong Kong to receive national-level, cross-border research funding under the "Young Scientist Scheme" of National Key Research and Development (R&D) Program from Ministry of Science and Technology (MOST) of China (PI, ~HK$6M, directly transferred to CUHK). [News is covered here.]

  1. Development of therapeutic strategies for musculoskeletal tissue regeneration.
  2. The mechanism for degenerative and inflammatory diseases.
  3. Cell based therapy and translational medicine.
  1. Li, K., Ning, T., Wang, H., Jiang, Y., Zhang, J., & Ge, Z. (2020). Nanosecond Pulsed Electric Fields Enhance Mesenchymal Stem Cells Differentiation via DNMT1 regulated OCT4/NANOG gene expression. Stem Cell Research & Therapy, doi:1186/s13287-020-01821-5.
  2. Chen, J., Huang, Y., Yang, J., Li, K., Jiang, Y. , Heng, B.C., Cai, Q., Zhang, J., & Ge, Z. (2020). Multiple Nanosecond Pulsed Electric Fields Stimulation with Conductive Poly (L‐lactic acid)/Carbon Nanotubes Films Maintains the Multipotency of Mesenchymal Stem Cells During Prolonged In Vitro Culture. Journal of Tissue Engineering and Regenerative Medicine, doi: 10.1002/term.3088.
  3. Zhou, Q., Cai, Y., Jiang, Y., & Lin, X. (2020). Exosomes in Osteoarthritis and Cartilage Injury: Advanced Development and Potential Therapeutic Strategies. International Journal of Biological Sciences, 16(11), 1811-1820, doi: 10.7150/ijbs.41637.
  4. Yang, L., Tang, C., Chen, Y., Ruan, D., Zhang, E., Yin, Z., Chen, X., Jiang, Y., Cai, Y., Fei, Y., Zhu, S., Liu, H., Hu, J., Heng, B.C., Chen, W., Shen, W., & Ouyang, H. (2019). Pharmacological Inhibition of Rac1 Activity Prevents Pathological Calcification and Enhances Tendon Regeneration. ACS Biomaterials Science & Engineering, 5 (7), 3511-3522, doi: 10.1021/acsbiomaterials.9b00335.
  5. Li, L., Jiang, Y., Lin, H., Shen, H., Sohn, J., Alexander, P.G., & Tuan, R.S. (2019). Muscle Injury Promotes Heterotopic Ossification by Stimulating Local Bone Morphogenetic protein-7 Production. Journal of Orthopaedic Translation, 18, 142-153, doi: 10.1016/j.jot.2019.06.001.
  6. Jiang, Y.*, & Tuan, R.S.* (2019). Role of NGF/TrkA Signaling in Calcification of Articular Chondrocytes. The FASEB Journal, 33(9), 10231-10239, doi: 10.1096/fj.201900970.
  7. Sun, J., Ma, X., Chu, H.T., Feng, B., Tuan, R.S., & Jiang, Y.* (2019). Biomaterials and Advanced Biofabrication Techniques in hiPSCs Based Neuromyopathic Disease Modeling. Front Bioeng Biotechnol, 29(7), 373, doi: 10.3389/fbioe.2019.00373.
  8. Huang, L., Wang, Y., Jiang, Y., Wu, Y., Hu, C., & Ouyang, H. (2018). High levels of GSK-3β signalling reduce osteogenic differentiation of stem cells in osteonecrosis of femoral head. Journal of Biochemistry, 1,163(3), 243-251, doi: 10.1093/jb/mvx076.
  9. He, J.#, Jiang, Y.#, Alexander, P.G., Ulici, V., Zhu, Y., Wu, S., & Tuan, R.S. (2017). Infrapatellar Fat Pad Aggravates Degeneration of Acute Traumatized Cartilage: A Possible Role for Interleukin-6. Osteoarthritis and Cartilage, 25(1), 138-145, doi: 10.1016/j.joca.2016.09.001.
  10. Zhou, F., Zhang, X., Cai, D., Li, J., Mu, Q., Zhang, W., Zhu, S., Jiang, Y., Shen, W., Zhang, S., & Ouyang, H. (2017). Silk Fibroin-chondroitin Sulfate Scaffold with Immuno-inhibition Property for Articular Cartilage Repair. Acta Biomaterialia, 63:64-75, doi: 10.1016/j.actbio.2017.09.005.
  11. Jiang, Y., Cai, Y., Zhang, W., Hu, C., Tong, T., Lu, P., Zhang, S., Neculai, D., Tuan, R., & Ouyang, H.W. (2016). Human Cartilage Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Translational Medicine, 5, 1-12, doi: 10.5966/sctm.2015-0192.
  12. Jiang, Y., Hu, C., Yu, S., Yan, J., Peng, H., Ouyang, H.W., & Tuan, R.S. (2015). Cartilage Stem/Progenitor Cells are Activated in Osteoarthritis via Interleukin-1β/Nerve Growth Factor Signaling. Arthritis Research and Therapy, 17, 327, doi: 10.1186/s13075-015-0840-x.
  13. Jiang, Y., & Tuan, R. (2015). Origin and Function of Cartilage Stem/Progenitor Cells in Osteoarthritis. Nature Reviews Rheumatology, 11(4), 206-12, doi:10.1038/nrrheum.2014.200.
  14. Xie, X., Ulici, V., Alexander, P.G., Jiang, Y., Zhang, C., & Tuan, R.S. (2015). Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes. Arthroscopy, 31(6), 1142-50, doi: 10.1016/j.arthro.2015.01.007.
  15. Zhang, W., Heng, B.C., Jiang, Y.*, & Ouyang, H.W.* (2014). Clinical Translation of Autologous Cell-based Tissue Engineering Techniques as Class III Therapeutics in China: Taking Cartilage Tissue Engineering as An Example. Journal of Orthopaedic Translation, 2(2), 56-65, doi: 10.1016/j.jot.2014.02.002.
  16. Jiang, Y., Chen, L., Zhang, S., Tong, T., Zhang, W., Liu, W., Xu, G., Tuan, R.S., Heng, B.C., Crawford, R., Xiao, Y., & Ouyang H.W. (2013). Incorporation of Bioactive Polyvinylpyrrolidone-iodine within Bilayered Collagen Scaffolds Enhances the Differentiation and Subchondral Osteogenesis of Mesenchymal Stem Cells. Acta Biomaterialia, 9(9), 8089-98, doi: 10.1016/j.actbio.2013.05.014.
  17. Zhang, S., Jiang, Y., Zhang, W., Chen, L., Tong, T., Liu, W., Mu, Q., Liu, H., Ji, J., Ouyang, H.W., & Zou, X. (2013). Neonatal Desensitization Supports Long-term Survival and Functional Integration of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression. Stem Cells and Development, 22(1), 90-101, doi: 10.1089/scd.2012.0116.
  18. Zhang, S., Chen, L., Jiang, Y., Cai, Y., Xu, G., Tong, T., Zhang, W., Wang, L., Ji, J., Shi, P., & Ouyang, H. (2013). Bi-layer Collagen/Microporous Electrospun Nanofiber Scaffold Improves the Osteochondral Regeneration. Acta Biomaterialia, 9(7), 7236-47, doi: 10.1016/j.actbio.2013.04.003.
  19. Zhang, W., Chen, J., Tao, J., Jiang, Y., Hu, C., Huang, L., Ji, J., & Ouyang, H.W. (2013). The Use of Type 1 Collagen Scaffold Containing Stromal Cell-Derived Factor-1 to Create a Matrix Environment Conducive to Partial-thickness Cartilage Defects Repair. Biomaterials, 34(3), 713-23, doi: 10.1016/j.biomaterials.2012.10.027.
  20. Shi, P., Jiang, Y., Hu, Z., Huang, Y., Zhang, J., Yu, H., Zou, X., & Ouyang, H. (2012). Clinical Research and Application of Autologous Chondrocyte Implantation. Chinese Journal of Orthopaedics, 32(1), 46-51, doi: 10.3760/cma.j.issn.0253-2352.2012.01.008.
  21. Cai, Y., Zhang, G., Wang, L., Jiang, Y., Ouyang, H.W., & Zou, X. (2012). Novel Biodegradable Three-dimensional Macroporous Scaffold Using Aligned Electrospun Nanofibrous Yarns for Bone Tissue Engineering. J Biomed Mater Res A, 100(5), 1187-94, doi: 10.1002/jbm.a.34063.
  22. Jiang, L., Song, X., Liu, P., Zeng, C., Huang, Z., Zhu, L., Jiang, Y., Ouyang, H., & Hu, H. (2012). Platelet-mediated Mesenchymal Stem Cells Homing to the Lung Reduces Monocrotaline-induced Rat Pulmonary Hypertension. Cell Transplantation, 21(7), 1463-75, doi: 10.3727/096368912X640529.
  23. Jiang, Y., Zhang, S., Wang, L., & Ouyang, H.W. (2011). Cell Transplantation for Articular Cartilage Defects: Principles of Past, Present and Future Practice. Cell Transplantation, 20(5), 593-607, doi: 10.3727/096368910X532738.
  24. Jiang, Y., Chen, L.K., Zhu, D.C., Zhang, G.R., Qi, Y.Y., & Ouyang, H.W. (2010). The Inductive Effect of Bone Morphogenetic Protein-4 on Chondral-lineage Differentiation and In Situ Cartilage Repair. Tissue Engineering Part A, 16(5), 1621-32, doi: 10.1089/ten.tea.2009.0681.
  25. Wang, W., Li, B., Li, Y., Jiang, Y., Ouyang, H., & Gao, C. (2010). In Vivo Restoration of Full-thickness Cartilage Defects by Poly(lactide-co-glycolide) Sponges Filled with Fibrin Gel, Bone Marrow Mesenchymal Stem Cells and DNA Complexes. Biomaterials, 31(23), 5953-65, doi: 10.1016/j.biomaterials.2010.04.029.
  26. Wang, W., Li, B., Yang, J., Xin, L., Li, Y., Yin, H., Qi, Y., Jiang, Y., Ouyang, H., & Gao, C. (2010). The Restoration of Full-thickness Cartilage Defects with BMSCs and TGF-beta 1 Loaded PLGA/fibrin Gel Constructs. Biomaterials, 31(34), 8964-73,doi: 10.1016/j.biomaterials.2010.08.018.
  27. Zou, X., Zhi, Y., Chen, X., Jin, H., Wang, L., Jiang, Y., Yin, Z., & Ouyang, H. (2010). Mesenchymal Stem Cell Seeded Knitted Silk Sling for the Treatment of Stress Urinary Incontinence. Biomaterials, 31(18), 4872-9, doi: 10.1016/j.biomaterials.2010.02.056.
  28. Zou, X.†, Jiang, Y.†, Zhang, G., Jin, H., Hieu, N.T., & Ouyang, H. (2009). Specific Interactions Between Human Fibroblasts and Particular Chondroitin Sulfate Molecules for Wound Healing. Acta Biomaterialia, 5(5), 1588-95, doi: 10.1016/j.actbio.2008.12.001.
  29. Qi, Y., Chen, X., Jiang, Y., Cai, H., Wang, L., Hieu, N.T., & Ouyang, H. (2009). Local Delivery of Autologous Platelet in Collagen Matrix Synergistically Stimulated In-situ Articular Cartilage Repair. Cell Transplantation, 18(10), 1161-9, doi: 10.3727/096368909X12483162197169.
  30. Zou, X., Cai, H., Yin, Z., Chen, X., Jiang, Y., Hu, H., & Ouyang, H. (2009). A Novel Strategy Incorporating the Power of Mesenchymal Stem Cells into Allografts for Segmental Bone Tissue Engineering. Cell Transplantation, 18(4), 433-41, doi: 10.3727/096368909788809839.

    * Corresponding / Co-corresponding author 
    # Co-first author

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  1. Ministry of Science and Technology (MOST) of China, National Key R&D Program, Young Scientist Scheme [PI; 2019 to 2023]: "Stem Cells and Translational Medicine" (HK$6,000,000).