張宗康 博士

履歷(教育及工作經驗)

教育：

1. 2005 上海復旦大學醫學院臨床醫學學士
2. 2007 上海復旦大學醫學院臨床醫學碩士
3. 2013 香港理工大學康復治療科學系博士

工作經驗：

1. 2005-2007 上海華山醫院手外科實習醫生
2. 2008-2008 香港理工大學康復治療科學系研究助理
3. 2010-2011 美國紐約石溪大學生物醫學工程訪問學者
4. 2011-2013 香港理工大學康復治療科學系兼職副研究員
5. 2013-2014 香港中文大學中醫學院研究助理
6. 2014-2017 香港中文大學中醫學院博士後研究員
7. 2017-2019 香港中文大學中醫學院副研究員
8. 2019至今 香港中文大學中醫學院研究助理教授

科研範圍

1. 肌肉骨骼系統疾病（老年性肌量減少症、失重性肌肉萎縮、肌肉創傷、骨質疏鬆、骨折和骨壞死）分子機理探索及基於中醫藥天然產物和基因干預策略的藥物開發研究

著作及論文（選列)

1. Zheng Y, Wang X, Zhang ZK#, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang BT, Zhang G and Lu A. Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial. Scientific Reports 2019; 9: 2089.
2. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading. Molecular Therapy 2018; 26(11).
3. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. Journal of Cachexia, Sarcopenia and Muscle 2018; 9(3):613-626.
4. Liang C, Wang L, Zhang ZK#, Wang C, Li J, He B, Zhu H, Zhang BT, Li F, Lu A, Zhang G. Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGF-A in osteosarcoma. Biomaterials 2017;147:68-85.
5. Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang ZK, Li J, Lv Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang BT, Lu A, Zhang G. A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nature Communications 2017; 8: 1390.
6. Zhang ZK, Guo X, Lao J, Qin YX. Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model. Journal of Orthopaedic Translation 2017; 10: 12–17.
7. Guo B, Zhang ZK#, Liang C, Li J, Liu J, Lu A, Zhang BT, Zhang G. Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism. Calcified Tissue International 2017; 100(2):184-192,.
8. He B, Zhang ZK#, Liu J, He YX, Tang T, Li J, Guo BS, Lu AP, Zhang BT, Zhang G. Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing. International Journal of Molecular Sciences 2016; 17(8): E1260.
9. Zhang ZK, Li J, Liu J, Guo B, Leung A, Zhang G, Zhang BT. Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading. Scientific Reports 2016; 6:20300.
10. Zhang ZK, Li J, Yan DX, Leung WN, Zhang BT. Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization. International Journal of Molecular Sciences 2016; 17(2): E169.