Professor Kin-ming KWAN

	Address	(Office):	Room EG03, Science Center East Block, CUHK
		(Lab):	Room G96, Science Center South Block, CUHK
	Phone	(Office):	(852) 3943 1008
		(Lab):	(852) 3943 6287
	Fax		(852) 2603 7246
	Email		kmkwan@cuhk.edu.hk
	Web		-

 

 

 

 

 

 

 

 

Education

	1997	Ph.D.	Department of Biochemistry, The University of Hong Kong
	1990	B.Sc. (1st class honours)	Biochemistry major, The University of Hong Kong, Hong Kong

 

 

 

 

Position

• Associate Professor, School of Life Sciences, The Chinese University of Hong Kong
• Programme Director, Natural Sciences Programme, Faculty of Science, The Chinese University of Hong Kong

 

Research Interests

• Genetic manipulation by transgenic and gene knockout technology
• Study of Organogenesis and Tumorigensis using mouse as model organism
• Neural development and neuronal cell biology

• Stem cell research

 

Representative Publications (*corresponding authors)

• Tong KK, *Kwan KM. (2013). Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Molecular and Cellular Biology 33: 1925-1937.

• Wong YL, Behringer RR and *Kwan KM. (2012) Ventral limb ectoderm Smad1/Smad5 signaling functions redundantly and is required in interdigital programmed cell death. Developmental Biology 367: 247-257.
• Tian XY, Yung LH, Wong WT, Liu J, Leung FP, Liu L, Chen Y, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X, Huang Y (2012). Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52: 237-244.
• Tam WY, Leung CK, Tong KK and *Kwan KM. (2011) Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum. Neuroscience 172: 562-571.
• Poché RA, Kwan KM, Raven MA, Furuta Y, Reese BE and Behringer RR. (2007) Lim1 is essential for the correct laminar positioning of retinal horizontal cells. Journal of Neuroscience 27: 14099-14107.
• #Zhao Y, #Kwan KM, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H. (2007) LIM-homeodomain proteins Lhx1, Lhx5, and their cofactor Ldb1 control Purkinje cell differentiation in the developing cerebellum. Proceedings of the National Academy of Sciences United States of America 104: 13182-13186.
• Tsang KY, Chan D, Cheslett D, Chan WCW, So CL, Melhado IG, Chan TWY, Kwan KM, Hunziker EB, Yamada Y, Bateman JF, Cheung KMC and Cheah KSE. (2007) Surviving ER Stress is coupled to altered chondrocyte differentiation and function. PLoS Biology 5(3): e44.
• Kwan KM, Li AG, Wang XJ, Wurst W and Behringer RR. (2004) Essential roles of BMPRIA signaling in differentiation and growth of hair follicles and in skin tumorigenesis. Genesis 39: 10-25.
• Kwan KM. (2002) Conditional alleles in mice: practical considerations for tissue-specific knockouts. Genesis 32: 49-62.
• Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP and Cheah KS. (1997) Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. Journal of Cell Biology 136: 459-471.

#equal contribution as first author.

 

Research Grants as PC/PI

• 2013-2015, Research Grants Council (RGC) GRF Grant “Functional analysis of Foxp4 in exocrine pancreas development and homeostasis in mouse”, HK$850,000;
• 2011-2013, RGC GRF Grant “Functional analysis of Foxp4 in Purkinje neurons of cerebellum in mice”, HK$986,000;
• 2010-2013, RGC CRF Grant “Functional analysis of Sox9 in neural progenitor cells of cerebellum in mice”, HK$1,039,170;
• 2009-2012, RGC GRF Grant “Functional analysis of Smad genes in granule neurons of cerebellum in mice”, HK$1,064,049;
• 2008-2011, RGC GRF Grant “Functional analysis of Lhx1 and Lhx5 in Purkinje neurons of cerebellum in mice”, HK$1,146,611.

 

Awards

• 2013: Science Faculty Exemplary Teaching Award 2013, CUHK
• 2009: Science Faculty Exemplary Teaching Award 2009, CUHK
• 2008: The Young Researcher Award 2008, CUHK
• 1991-1994: The Croucher Foundation Scholarship, Hong Kong

Professional Activities

• Secretary, Hong Kong Society for Development Biology