Professor LAI Bo San Paul    
賴寶山

Professor
MBChB (CUHK), MD (CUHK), FCSHK, FHKAM (Surgery), FRCSEd (Gen), FRCS (Glas), FRACMA, FHKCCM

Hepato-biliary and Pancreatic Surgery
(852) 3505 1496
paullai@cuhk.edu.hk
K-8556-2015
0000-0002-9469-6728

Biography

Prof. Lai graduated from CUHK and joined the department in 1990. He received surgical training in Hong Kong and Edinburgh and specialized in hepato-biliary and pancreatic surgery. Apart from being an active practicing surgeon, teacher for medical students and trainer for surgical trainees, Prof. Lai is actively involved in both clinical and basic scientific research. He is also the editor-in-chief of the journal Surgical Practice and a member of editorial boards of a number of local and international academic journals, such as British Journal of Surgery and Annals of Surgical Oncology.

Prof. Lai has been the Director of the Office of Medical Education (OME) since 2014 and the OME serves to oversee the MBChB curriculum of the Faculty of Medicine, the Chinese University of Hong Kong.

Prof. Lai has developed an interest in surgical outcome research, quality and risk management, healthcare policy, medico-legal and mediation. He has studied for a master degree in medical law at the University of Northumbria and he is an accredited mediator in Hong Kong under the Hong Kong Mediation Accreditation Association Limited (HKMAAL). He has contributed to training and education of healthcare professionals in various areas and is an experience examiner in the Faculty and College of Surgeons of Hong Kong.

In the field of hospital administration, Prof. Lai was previously the Honorary Chief of Service in the Department of Surgery at the Prince of Wales Hospital and the Cluster Coordinator for Surgical Services in New Territories East Cluster from 2008 to 2018. He was elected as a fellow of the Royal Australasian College of Medical Administrators, a fellow of the Faculty of Public Health and a fellow of the Hong Kong College of Community Medicine (Administrative Medicine) in 2018. He has also been appointed as the Medical Director, Quality & Safety at the Chinese University of Hong Kong Medical Centre since July 2019.

Research Interests

• Clinical research in general surgery and hepato-biliary and pancreatic surgery
• Molecular genetics of liver cancer and other cancers
• Hospital administration, quality and risk management
• Surgical outcome research
• Medico-legal study and mediation
• Medical education research

Additional Information

Current positions in the Faculty of Medicine, the Chinese University of Hong Kong:

• Professor and Division Chief, Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery
• Director of the Wong Tze Lam - Hing Tak Centre of Surgical Outcome Research
• Director, Office of Medical Education, Faculty of Medicine
• Professor (by courtesy), of the School of Biomedical Sciences

Current positions in the Hospital Authority:

• Honorary Consultant HBP Surgeon, Department of Surgery, Prince of Wales Hospital
• Head of Cluster HBP Surgery Services, New Territories East Cluster, Hospital Authority
• Director, Surgical Outcomes Monitoring & Improvement Program (SOMIP), Hospital Authority Head Office

Current positions in the College of Surgeons of Hong Kong and the Hong Kong Academy of Medicine:

• Immediate Past President (since September 2019)
• Editor-in-chief of Surgical Practice (the official journal for the College of Surgeons of Hong Kong)
• Deputy Chairman, Education Committee, Hong Kong Academy of Medicine (since October 2019)

Selected Publications

1. Wang N, Li MY, Liu Y, Yu J, Ren J, Zheng Z, Wang S, Yang S, Yang SL, Liu LP, Hu BG, Chong CC, Merchant JL, Lai PB, Chen GG. ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway. Cancer Lett. 2020 Mar 1;472:70-80. doi: 10.1016/j.canlet.2019.12.026. Epub 2019 Dec 23. PMID: 31874246; PMCID: PMC7226908.
2. Chong CCN, Lee KF, Cheung SYS, Chu CCM, Fong AKW, Wong J, Hui JWY, Fung AKY, Lok HT, Lo EYJ, Chan SL, Yu SCH, Ng KKC, Lai PBS. Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial). HPB (Oxford). 2020 Feb 8:S1365-182X(20)30023-X. doi: 10.1016/j.hpb.2020.01.008. Epub ahead of print. PMID: 32044268.
3. Chan TT, Chan WK, Wong GL, Chan AW, Nik Mustapha NR, Chan SL, Chong CC, Mahadeva S, Shu SS, Lai PB, Chan HL, Wong VW. Positive Hepatitis B Core Antibody Is Associated With Cirrhosis and Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2020 Jun;115(6):867-875. doi: 10.14309/ajg.0000000000000588. PMID: 32149781.
4. Ren J, Liu Y, Wang S, Wang Y, Li W, Chen S, Cui D, Yang S, Li MY, Feng B, Lai PBS, Chen GG. The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3. J Biol Chem. 2020 Apr 17;295(16):5484-5495. doi: 10.1074/jbc.RA120.012518. Epub 2020 Mar 20. PMID: 32198183; PMCID: PMC7170510.
5. Søreide K, Hallet J, Matthews JB, Schnitzbauer AA, Line PD, Lai PBS, Otero J, Callegaro D, Warner SG, Baxter NN, Teh CSC, Ng-Kamstra J, Meara JG, Hagander L, Lorenzon L. Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services. Br J Surg. 2020 Apr 30:10.1002/bjs.11670. doi: 10.1002/bjs.11670. Epub ahead of print. PMID: 32350857; PMCID: PMC7267363.
6. Liu YH, Lo EYJ, Lee KF, Chong CCN, Lai PBS. An unusual cause of upper gastrointestinal bleeding due to recurrent hepatocellular carcinoma: A case report. Int J Surg Case Rep. 2020;70:83-86. doi: 10.1016/j.ijscr.2020.04.008. Epub 2020 May 11. PMID: 32416488; PMCID: PMC7226638.
7. Ding X, He M, Chan AWH, Song QX, Sze SC, Chen H, Man MKH, Man K, Chan SL, Lai PBS, Wang X, Wong N. Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. Gastroenterology. 2020 May 16:S0016-5085(20)30659-4. doi: 10.1053/j.gastro.2019.09.056. Epub ahead of print. PMID: 32428506.
8. Gong Z, Yu J, Yang S, Lai PBS, Chen GG. FOX transcription factor family in hepatocellular carcinoma. Biochim Biophys Acta Rev Cancer. 2020 May 11;1874(1):188376. doi: 10.1016/j.bbcan.2020.188376. Epub ahead of print. PMID: 32437734.
9. Fung AKY, Chong CCN, Lai PBS. ERAS in minimally invasive hepatectomy. Ann Hepatobiliary Pancreat Surg. 2020 May 31;24(2):119-126. doi: 10.14701/ahbps.2020.24.2.119. PMID: 32457255; PMCID: PMC7271107.
10. Lee KF, Wong RHL, Leung HHW, Lo EYJ, Chong CCN, Chan AWH, Lai PBS. En bloc transdiaphragmatic lung resection for locally advanced hepatocellular carcinoma: a case report. J Surg Case Rep. 2020 Jun 15;2020(6):rjaa084. doi: 10.1093/jscr/rjaa084. PMID: 32577199; PMCID: PMC7297557.