Department of Anaesthesia and Intensive Care CUHK

Dr. Chuan XIE
MBBS, MD, PhD

Postdoctoral researcher
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Research Interests
Helicobacter pylori, Autophagy

Publications:

For details about citations arising from my publications and links to online versions of some of the publications, refer to: https://publons.com/researcher/3991782

(*corresponding author, ^co-first author)

2020

Xie C, Li N, Wang H, He C, Hu Y, Peng C, Ouyang Y, Wang D, Xie Y, Chen J, Shu X, Zhu Y, Lu N*. Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection. Gut Microbes. 2020 Jun 26:1-23.

2019

Li N, Lu N, Xie C*. The Hippo and Wnt signalling pathways: crosstalk during neoplastic progression in gastrointestinal tissue. FEBS J. 2019 Jul 25.

Fu L, Xie C*. A lucid review of Helicobacter pylori-induced DNA damage in gastric cancer. Helicobacter. 2019 Jul 11:e12631.

Hu Y, Liu JP, Li XY, Cai Y, He C, Li NS, Xie C, Xiong ZJ, Ge ZM, Lu NH*, Zhu Y*. Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin β-1/NF-κB signaling pathway. Cancer Lett. 2019 May 28;450:144-154.

2018

C Xie^, J Yi^, J Lu^, MW Nie, MF Huang, JF Rong, ZH Zhu, J Chen, XL Zhou, BM Li, HM Chen, NH Lu, Xu Shu*. N-acetylcysteine reduces ROS-mediated oxidative DNA damage and PI3K/Akt pathway activation induced by Helicobacter pylori infection. Oxidative Medicine and Cellular Longevity. 2018 Apr 26;2018:1874985.

Xu W, Huang Y, Yang Z, Hu Y, Shu X, Xie C, He C, Zhu Y, Lu N*. Helicobacter pylori promotes gastric epithelial cell survival through the PLK1/PI3K/Akt pathway. Onco Targets Ther. 2018 Sep 11;11:5703-5713.

Xu W, Yang Z, Xie C, Zhu Y, Shu X, Zhang Z, Li N, Chai N, Zhang S, Wu K, Nie Y, Lu N*. PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis. J Exp Clin Cancer Res. 2018 Aug 22;37(1):198.

Yang Z, Cao X, Xu W, Xie C, Chen J, Zhu Y, Lu N*. Phosphorylation of phosphatase and tensin homolog induced by Helicobacter pylori promotes cell invasion by activation of focal adhesion kinase. Oncol Lett. 2018 Jan;15(1):1051-1057.

He C, Yang Z, Cheng D, Xie C, Zhu Y, Ge Z, Luo Z, Lu N*. Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice. EBioMedicine.

Li N, Feng Y, Hu Y, He C, Xie C, Ouyang Y, Artim SC, Huang D, Zhu Y, Luo Z, Ge Z, Lu N*. Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway. J Exp Clin Cancer Res. 2018 Nov 22;37(1):280.

2017

C Xie^, Z Yang^, Y Hu, XM Cao, J Chen, Y Zhu, NH Lu*. Expression of c-Met and Hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett. 2017 Nov;14(5):6151-6155.

Li N^, Xie C^, Lu NH*. Crosstalk between Hippo signalling and miRNAs in tumour progression. FEBS J. 2017 Apr;284(7):1045-1055. (Co-first authors.)

Ye JF, Hong JB, Zhu Y, Xie Y, Shu X, Luo LY, Xie C, Zhu ZH, Lu NH*. Evaluation of first-line bismuth-containing 7-day concomitant quintuple therapy for Helicobacter pylori eradication. J Dig Dis. 2017 Dec;18(12):704-708.

2016

Li N, Xie C^, Lu NH*. p53, a potential predictor of Helicobacter pylori infection-associated gastric carcinogenesis? Oncotarget. 2016 Aug 19.
Hong J, Shu X, Liu D, Zhu Y, Xie C, Xie Y, Zhang K, Wang A, Xiong H, Zeng H, Yu H, Ma J, Chen Y, Zhu X, Lu N*. Antibiotic resistance and CYP2C19 polymorphisms affect the efficacy of concomitant therapies for Helicobacter pylori infection: an open-label, randomized, single-centre clinical trial. J Antimicrob Chemother. 2016 Aug;71(8):2280-5.

2015 or before

Xie C, Lu NH*. Clinical management of Helicobacter pylori infection in China. Helicobacter. 2015 Feb;20(1):1-10.

XG Yuan^, C Xie^, CY Zeng, J Chen, X Shu, Y Xie, KH Zhang, NH Lu*. Seasonal changes in gastric mucosal factors associated with peptic ulcers bleeding. Exp Ther Med. 2015 Jan;9(1):125-130.

Li NS^, Xie C^, Lu NH*. Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis. Front Cell Infect Microbiol. 2015; Nov 4;5:77.

Yang Z, Xie C, Xu W, et al. Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway. Oncotarget 2015; 6(31): 31916-26.
Yang Z, Li W, He C, Xie C, Zhu Y, Lu NH*. Potential effect of chronic Helicobacter pylori infection on glucose metabolism of Mongolian gerbils. World journal of gastroenterology 2015; 21(44): 12593-604.

Xie C, Xu LY, Li W, Yang Z, Lu NH*. Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases. World J Gastroenterol. 2014 Sep 14;20(34):12308-12.
Xie C, Xu LY, Yang Z, Cao XM, Li W, Lu NH*. Expression of γH2AX in various gastric pathologies and its association with Helicobacter pylori infection. Oncol Lett 2014; 7: 159-163.
Yu M, Wang Q, Ding JW, Yang Z, Xie C, Lu NH*. Association between raf kinase inhibitor protein loss and prognosis in cancers of the digestive system: A meta-analysis. Cancer Biomarkers 2014; 14(5): 389-400.
Yu M, Zhang Y, Yang Z, Ding J, Xie C, Lu N*. Association between Helicobacter pylori Infection and Stroke: A Meta-analysis of Prospective Observational Studies. Journal of Stroke & Cerebrovascular Diseases 2014; 23(9): 2233-9.

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