TEST NAME

SPECIMEN/REQUIREMENT

Routine Histopathology

Biopsy

Fixed in 10% buffered formalin.

Surgical Excision

Fixed in 10% buffered formalin.

Special Biopsies

Renal Biopsy, with IF Profile

Fresh specimen required. Specimen should be placed in normal saline and sent to laboratory with “Proforma” as soon as possible.

Skin Biopsy, with IF Profile

Fresh specimen required. Specimen should be wrapped by gauze wetted with normal saline and sent to laboratory as soon as possible.

Skin Biopsy, without IF Profile

Fixed in 10% buffered formalin or sent fresh.

Rectal Biopsy, with Histochemistry for Ganglionic Cells 

Fresh specimen required. Specimen should be wrapped by gauze wetted with normal saline and sent to laboratory as soon as possible.

Molecular Tests

EGFR (exons 18-21) Mutation Test

(FDA approved)

Tissue Block / Cell Block

EGFR (exons 18-21) Mutation Test on pleural fluid

Fresh pleural fluid. Advance booking is required.

EGFR (exons 18-21)

Mutation Test on peripheral blood

4 x 3mL Peripheral blood with EDTA anti-coagulant. Advance booking is required

KRAS (codons 12, 13, 61, 117, 146) Mutation Test

Tissue Block / Cell Block

NRAS (codons 12, 13, 61, 117, 146) Mutation Test

Tissue Block / Cell Block

BRAF V600E Mutation Test

Tissue Block / Cell Block

ALK Translocation Test by FISH (FDA approved)

Tissue Block / Cell Block

HER-2 FISH for breast cancer (FDA approved)

Tissue Block

HER-2 FISH for gastric cancer (FDA approved) *

Tissue Block

RET FISH Test

Tissue Block

ROS-1 FISH Test

Tissue Block

c-MET Mutation Test

(Exon 14 splice site alteration)

Tissue Block

c-MET Amplification Test by FISH

Tissue Block

C-Kit Mutation Test

Tissue Block

c-KIT & PDGFRA Mutation Test

Tissue Block

MGMT Promoter Hypermethylation Test

Tissue Block

1p/19q FISH Test

Tissue Block

IDH 1 Mutation Test

Tissue Block

Special Tests Pharmacogenetics Tests Package for NSCLC

EGFR Mutation + ALK Translocation FISH Test

Tissue Block / Cell Block

EGFR Mutation + ALK Translocation FISH Test + KRAS Mutation Test

Tissue Block / Cell Block

Sequential Test: EGFR Mutation –ve à ALK Translocation FISH Test

Tissue Block / Cell Block

Sequential Test: EGFR Mutation –ve à ALK Translocation FISH Test + KRAS Mutation Test

Tissue Block / Cell Block

Pharmacogenetics Tests Package for mCRC

KRAS Mutation + NRAS Mutation Test

Tissue Block / Cell Block

Molecular Tests for Solid Cancer Fusion Transcripts (by RT-PCR)

EWSR1-FLI1,EWSR1-ERG

for Ewing Sarcoma

Tissue Block

ASPSL-TFE3

for Alveolar Soft Part Sarcoma

Tissue Block

BRD4-NUT BRD3-NUT

for NUT Midline Carcinoma

Tissue Block

COL1A1-PDGFB

for Dermatofibrosarcoma Protuberans,Giant Cell Fibroblastoma

Tissue Block

ETV6-NTRK3 for Congenital/Infantile Fibrosarcoma, Congenital MesoblasticNephroma

Tissue Block

EWSR1-ATF1,EWSR1-CREB1

for Clear Cell Sarcoma

Tissue Block

FUS-CREB3L2, FUS-CREB3L1

for Low-Grade Fibromyxoid Sarcoma

Tissue Block

MECT1-MAML2

for Mucoepidermoid Carcinoma

Tissue Block

MYB-NFIB

for Adenoid Cystic Carcinoma

Tissue Block

NR3A3-EWS

for Extraskeletal Myxoid Chondrosarcoma

Tissue Block

PAX3-FOXO1A, PAX7-FOXO1A

for Alveolar Rhabdomyosarcoma

Tissue Block

SYT-SSX1,SYT-SSX2

for Synovial Sarcoma

Tissue Block

TPM3-ALK, TPM4-ALK, CLTC-ALK, RANBP2-ALK

for Inflammatory myofibroblastic tumor

Tissue Block

Molecular Tests for Sarcoma (by FISH)

EWSR1 Translocation test (FISH)

Tissue Block

DDIT3 Translocation test (FISH)

Tissue Block

FOXO1 Translocation test (FISH)

Tissue Block

FUS Translocation test (FISH)

Tissue Block

SS18 Translocation test (FISH)

Tissue Block

CDK4 Amplification Test (FISH) for liposarcoma

Tissue Block

MDM2 Amplification (FISH)

Tissue Block

TFE3 Translocation Test (FISH)

Tissue Block

Molecular Tests for Lymphoma / Lymphoproliferative Disorders

TCR-beta / gamma Clonality Test

Tissue Block / 3ml EDTA PB / BM

IgH Clonality Test

Tissue Block / 3ml EDTA PB / BM

IgK + IgL Clonality Test

Tissue Block / 3ml EDTA PB / BM

BCL-2 Translocation test by FISH

Tissue Block

BCL-6 Translocation test by FISH

Tissue Block

c-MYC Translocation test by FISH

Tissue Block

ETV6 Translocation Test (FISH)

Tissue Block

MALT1 Translocation Test (FISH)

Tissue Block

MYD88 L265P Mutation Test

Tissue Block / 3ml EDTA PB / BM

Other Molecular Tests

Digene High Risk HPV Test

4 mL PreservCyt (ThinPrep) specimen

M ycobacterium Tuberculosis real-time PCR test

Tissue Block/ Cell Block

Specimen Identity Test (DNA fingerprinting)

Tissue Block / 3 mL PB

Special Tests

Histochemical Staining (Special / Enzyme Stains)

Immunohistochemical Markers, Paraffin or Frozen

Immunoelectron Microscopy, examined

In-Situ Hybridization (ISH) for EBER

Hormone Receptor for Breast Cancer (ER, PR, c-erbB2, Ki67)

Tissue block

Lymphoma Typing

Tissue block

Cytology

Cervical Smear (Autocyte, ThinPrep)

Semen Analysis

Non-Gynae (e.g. Sputum, Bronchial lavage, Body fluids, etc.)

Miscellaneous Items

Slide Consultation (Case Review, Surgical or Cytology)

No specific requirement

*** Please call 2632-3949 for advance booking.