Prof. DUAN, Liting
Assistant Professor, Department of Biomedical Engineering, CUHK
ltduan@cuhk.edu.hk
Tel: 3943 8268
Location: ERB1116
Lab webpage: ltduan.com
About
Liting received a Bachelor degree in Chemistry from Renmin University of China (People’s University of China) in 2010 where she worked on the fabrication and application of micro/nano-patterned structures using hot micro-contact printing. She moved from material engineering to biochemistry/biophysics for her doctoral studies at Stanford University (Ph.D. in Chemistry 2016). Her thesis focused on the development of optogenetic strategies to control intracellular activities. During postdoctoral research, she further studied and engineered the photosensory proteins interactions for optimized optogenetic toolkit at Stanford. In July 2018, she joined the Department of Biomedical Engineering in the Chinese University of Hong Kong as an Assistant Professor.
Professional Education and Training
2016 Ph.D. in Chemistry, Stanford University
2010 B.S. in Chemistry, Renmin University of China
Research Interest
· Development of optogenetic strategies to control intracellular activities;
· Intracellular signaling;
· Organelle dynamics;
Course Teaching in CUHK
BMEG2011 Biomedical Engineering Laboratory and Hospital Experience
BMEG3140 Molecular and Cellular Engineering Laboratory
BMEG3330 Neuroengineering
ENGG5601 Biomechanics & Biomaterials
Selected Publications
P. Huang, A. Liu, Y. Song, J. Hope, B. Cui, L. Duan*. Optical activation of TrkB signaling. J. Mol. Biol. (2020). 432(13), 3761.
P. Huang, Y. Song, N. Zhang, Z. Zhao, L. Duan*. Optogenetics based on light-gated protein-protein interactions and its applications. Chinese Journal of Lasers. (2020). 47(2), 0207010. (invited review)
H.Y. Lou, W. Zhao, X. Li, L. Duan, A. Powers, M. Akamatsu, F. Santoro, A.F. McGuire, Y. Cui*, D.G. Drubin* & B. Cui*. Membrane curvature underlies actin reorganization in response to nanoscale surface topography. Proc Natl Acad Sci U S A (2019).
L. Duan‡ , J. Hope‡, S. Guo‡, Q. Ong, A. Fracois, L. Kaplan, G. Sherrer, B Cui*. Optogenetic control of TrkA signaling. ACS Synth. Biol., 2018, 7 (7), 1685.
L. Duan, J. Hope, Q. Ong, H. Lou, N. Kim, C. McCarthy, V. Acero, M. Lin*, B. Cui*. Understanding CRY2 interactions for optical control of intracellular signaling. Nat. Commun., 2017, 8(1),547.
L. Duan‡, D. Che‡, K. Zhang, Q. Ong, S. Guo, B. Cui*. Optogenetic control of molecular motors and organelle distributions in cells. Chem. Biol., 2015, 22(5), 671.
D. Che‡ , L. Duan‡ , K. Zhang, B. Cui*. The dual characteristics of light-induced cryptochrome 2 homo-oligomerization and hetero-dimerization for optogenetic manipulation in mammalian cells. ACS Syn. Biol., 2015, 4 (10), 1124.
