BSc (First Hons), PhD (University of Warwick, U.K.)
Professor
Room 163 Science Centre
(852) 3943 6260
(852) 2603 5057
twdchan@cuhk.edu.hk
Professional Activities
| 2006 | Organiser of the 4th International Uppsala Conference on Electron Capture and Dissociation Mass Spectrometry — Fundamental and Applications |
| 2005 | President-Hong Kong Society for Mass Spectrometry (HKSMS) |
| 2001 | President-Hong Kong Society for Mass Spectrometry (HKSMS) |
| 2000 | President-Hong Kong Society for Mass Spectrometry (HKSMS) |
| 1999 | Vice president-Hong Kong Society for Mass Spectrometry (HKSMS) |
| 1998 | Founding Member–Hong Kong Society for Mass Spectrometry (HKSMS) |
| 1998 | Member of the Editorial Advisory Board 1. European Journal of Mass Spectrometry 2. Journal of Chinese Mass Spectrometry Society |
| 1998 | External Assessor for Grant Applications 1. HK Research Grants Council 2. HK Baptist University 3. Academic Sinica, Taiwan |
| 1998 | Peer Reviewer for Research Papers 1. Journal of American Society for Mass Spectrometry 2. European Journal of Mass Spectrometry 3. Rapid Communication in Mass Spectrometry Inorganic Chemistry Communication |
| 1998 | Member of American Society for Mass Spectrometry |
| 1998 | Chief Examiner of the HK A-Level Chemistry Examination—Service to Hong Kong Examination Authority |
| 1998 | Organiser of two-week Training Workshop on Mass Spectrometry and State-of-the-Art Mass Spectrometry Instruments for PRC Young Scientists |
Honours and Awards
| 2002 | Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong |
Research Interests
| 1. | Development of new mass spectrometry interfaces: -MALDI interface for FTMS -Nanospray & nano-LC interface for FTMS |
| 2. | Experimental and theoretical investigations of the novel mass spectrometry dissociation methods for structural analysis of proteins and DNA fragments |
| 3. | Detection and characterization of bioactive polysaccharides from herbal medicines |
Positions Available
| We are looking for PhD students with research interest in mass spectrometry and will provide full financial support to the successful applicants. Applicants should apply with a resume, a transcript and a grade of English test (TOEFL or CET-6) to Prof. Chan at twdchan@cuhk.edu.hk. |
Research Grants/Funding
Total Amount (1994-2006: HKD 14.48 millions)
| 2006 | Sponsorship of International Conference The Croucher Foundation |
| 2006 | Earmarked Grants Research Grants Council, HKSAR |
| 2004 | Earmarked Grants Research Grants Council, HKSAR |
| 2003 | Earmarked Grants Research Grants Council, HKSAR |
| 2002 | Summer Research Grants, The Chinese University of Hong Kong |
| 2002 | Special Equipment Grants, The Chinese University of Hong Kong |
| 2002 | Direct Grants, The Chinese University of Hong Kong |
| 2000 | Earmarked Grants Research Grants Council, HKSAR |
| 1998 | Earmarked Grants Research Grants Council, HKSAR |
| 1997 | Direct Grants, The Chinese University of Hong Kong |
| 1997 | Joint HK/UK Research Scheme, British Council |
| 1997 | Lee Hysan Foundation Fund |
| 1997 | One-time Support Funded Projects, The Chinese University of Hong Kong |
| 1996 | Earmarked Grants Research Grants Council, HKSAR |
| 1995 | Earmarked Grants Research Grants Council, HKSAR |
| 1995 | Direct Grants, The Chinese University of Hong Kong |
| 1994 | Direct Grants, The Chinese University of Hong Kong |
Research Collaborations
| 1. | University of Washington, Seattle, USA |
| 2. | Uppsala University, Sweden |
| 3. | University of Warwick, United Kingdom |
| 4. | Chinese Academy of Sciences, PRC |
| 5. | Peking University, PRC |
| 6. | Tsinghua University, PRC |
| 7. | Hong Kong University of Science & Technology, Hong Kong |
| 8. | Institute of Chinese Medicine, The Chinese University of Hong Kong |
| 9. | Faculty of Medicine, The Chinese University of Hong Kong |
Publications
| 1. | “Electron Caption Dissociation of Peptides Metalated with Alkaline Earth Metal Ions” J. Am. Mass Spectrom. 2006, 17, 757. |
| 2. | “Analyses of Stemona Alkaloids in Stemona Tuberosa by Liquid Chromatography / Tandem Mass Spectrometry, Y. Zhou, R.-W. Jaing, P.-M. Hon, Y.-T. Xu, Y.-M. Chan, T.-W. D. Chan, H.-X. Xu, L.-S. Ding, P. P.-H. But, P.-C. Shaw, Rapid Commun. Mass Spectrom., 2006, 20, 1030. |
| 3. | “Determination of molecular weight profile for a bioactive β-(1→3) polysaccharides –curdlan”, T.-W. D. Chan, P.K. Chan and K.Y. Tanf, Anal. Chim. Acta, 2006, 556, 226. |
| 4. | “Facile disulfide bond cleavage in gaseous peptide and protein cations by 157-nm ultra-violet photo-dissociation”, Eva Y. M. Fung, Frank Kjeldsen, Oleg A. Silivra, T.-W. D. Chan and Roman A. Zubarev, Angew. Chem. Int. Ed., 2005, 44, 2. |
| 5. | “Experimental and theoretical investigations of the loss of amino acid side chains in electron capture dissociation of model peptides”, Y. M. E. Fung and T.-W. D. Chan, J. Am. Soc. Mass Spectrom., 2005,16, 1523. |
| 6. | “A modified internal lock-mass method for calibration of the product ions derived from sustained off-resonance irradiation collision-induced dissociation (SORI-CID) using a Fourier transform mass spectrometer (FTMS)” L. Duan and T.-W. D. Chan, Rapid Commun. Mass Spectrom., 2004, 18, 1286. |
| 7. | “A comparative study of the collision induced dissociation and the electron capture dissociation of model peptides using ESI-FTMS” Y.M.E. Fung, L. Duan and T.-W. D. Chan, Euro. J. Mass Spectrom., 2004, 10, 449. |
| 8. | “Analysis of a bioactive β-(1→3) polysaccharide (Curdlan) by using matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOFMS)” T.-W.D. Chan and K. Y. Tang, Rapid Commun. Mass Spectrom., 2003, 17, 1. |
| 9. | “Accurate mass measurements for peptide and protein mixtures by using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)”, T.-W. D. Chan, L. Duan and T.-P. E. Sze, Anal. Chem., 2002, 74, 5282. |
| 10. | “Optimization of Experimental Parameters for Electron Capture Dissociation of Peptides in a Fourier Transform Mass Spectrometer (FTMS)”, T.-W.D. Chan and W.H.H. Ip, J. Am. Soc. Mass Spectrom.,2002, 13, 1396. |
| 11. | “A study of fast and metastable dissociations of adenine-thymine binary-based oligonucleotides by using positive-ion MALDI-TOF mass spectrometry”, T.-W. D. Chan, Y. M.E. Fung and Y. C. L. Li, J. Am. Soc. Mass Spectrom., 2002, 13, 1052. |
| 12. | “Tetrapyrrole derivatives substituted with ferrocenylethynyl moieties. Synthesis and Electrochemical studies”, K-W. Poon, W. liu, P-K. Chan. Q. Yang, T-W. D. Chan, T.C.W. Mak and D.K.P. Ng, J. Org. Chem., 2001, 66, 1553. |
| 13. | “Antioxidative Glucosides from the fruits of Ligustrum lucidium”, Z-D. He, P.P-H. But, T-W.D. Chan, H. Dong, H-X. Xu, C-P. Lau and H-D. Sun, Chem. Pharm. Bull, 2001, 49, 780. |
| 14. | “Sequence analysis of peptides with biological activities using electrospray-Fourier transform ion cyclotron resonance mass spectrometry”, M. He, J. Xu, T-W. D. Chan and R.L.C. Lau, Chinese Science Bulletin, 2001, 46, 1281. |
| 15. | “Effect of sample preparation methods on the analysis of dispersed polysaccharides by MALDI-TOF mass spectrometry, Rapid Commun. Mass Spectrom., 2000, 14, 1841. |
| 16. | “Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS”, T-W.D. Chan, P.P.H. But, S.W. Cheng, I.M.Y. Kwok, F.W. Lau and H.X. Xu, Anal. Chem.,2000, 72, 1281. |
| 17. | “Differentiation of enantiomers by using matrix-assisted laser desorption / ionization (MALDI) mass spectrometry”, M.P. So, T.S.M. Wan and T-W.D. Chan, Rapid Commun. Mass Spectrom., 2000, 14, 692. |
| 18. | “Synthesis and structural characterization of highly chlorinated, brominated, iodinated, and methylated carbroane anions, H-1-CB9X9–, NH2-1-CB9X9– (X = Cl, Br, I), and H-1-CB9(CH3)9–“, Inorg. Chem., 2000, 39, 3582. |
| 19. | “Weakly coordinating nature of a carborane cage bearing different halogen atoms. Synthesis and structural characterization of icosahedral mixed halocarborane anions, 1-H-CB11Y5X6– (X, Y = Cl, Br, I)”, Inorg. Chem., 2000, 39, 5851. |
| 20. | “Time-of-flight effects in matrix-assisted laser desorption / ionization Fourier transform mass spectrometry”, E.T-P. Sze and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1999, 13, 1. |
| 21. | “A novel non-metallized tip for electrospray mass spectrometry at nanoliter flow rate”, K.W.Y. Fong and T-W.D. Chan, J. Am Mass Spectrom. Soc., 1999, 10, 72. |
| 22. | “Highly Chlorinated, brominated, and iodinated icosahedral carbonane anions: 1-H-CB11X11–, 1-CH3-CB11-X11– (X = Cl, Br, I); 1-Br-CB11B11–“, Z. Xie, C-W. Tsang, E.T-P. Sze, Q. Yang, T-W.D Chan and T.C.W. Mak, Inorg. Chem., 1998, 37, 6444. |
| 23. | “Evaluation of ammonium salts as co-matrices for matrix-assisted laser desorption / ionization mass spectrometry of oligonucleotides”, Y.C.L. Li, S-W. Cheng and T-W.D. Chan, Rapid Commun. Mass Spectrom., 1998, 12, 993. |
| 24. | “Origins of proton in the generation of ions from polymers and peptides in matrix-assisted laser desorption / ionization”, C.K.L. Wong, M.P. So and T-W.D. Chan; Euro. Mass Spectrom., 1998, 4, 223. |
| 25. | “Formulation of matrix solutions for use in matrix-assisted laser desorption / ionization (MALDI) of Biomoelcules”, E.T.P. Sze, G. Wang and T-W.D. Chan; J. Am Mass Spectrom. Soc., 1998, 9, 166-174. |
| 26. | “Cationization processes in matrix-assisted laser desorption / ionization mass spectrometry : Attachment of divalent and trivalent metal ions”, C.K.L. Wong and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1997, 11, 513-519. |
| 27 | “Fourier Transform ion cyclotron resonance studies of Lanthanide(III) porphyrin-phthalocyanine heteroleptic sandwich complexes using electrospray ionization”, R.L.C. Lau, J.Jiang, D.K.P. Ng and T-W.D. Chan; J. Am Mass Spectrom. Soc., 1997, 8, 161-169. |
| 28. | “Sesquterpene lactones from Elephantopus scaber”, P.P-H. But, P-M.Hon, T-W.D. Chan, T.C.W. Mak and C-T. Che; Phytochemistry, 1997, 44, 113-116. |
| 29. | Synthesis, spectroscopic and electrochemical properties of substituted bis(phthalocyaninato)lanthanide(III) complexes”, J. Jiang, R.C.W. Liu, T.C.W. Mak, T-W.D. Chan and D.K.P. Ng, Polyhedron, 1997, 16, 515-520 |
| 30. | “Synthesis and spectroscopic properties of heteroleptic sandwich-type (phthalocyaninato)(porphyrinato)lanthanide(III) complexes”, J. Jiang, R.L.C. Lau, T-W.D. Chan, T.C.W. Mak and D.K.P. Ng; Inorg. Chim Acta, 1997, 255, 59-64. |
| 31. | “Mass spectra of hydrazo, azo and azoxy compound”, T-W.D. Chan and S.W. Tam, in The Chemistry of Hydrazo, Azo and Azoxy Groups, vol. 2, edited by S. Patai, John Wiley, & Sons Ltd., Chichester, 1997, Chap. 4, pp. 105-135. |
| 32. | “Dendritic models of redox proteins: X-ray photoelectron spectroscopy and cyclic voltammetry studies of dendritic bis(terpyridine) iron(II) complexes”, H-F Chow, Y-K. I Chan, T-W. D Chan and R.W.M. Kwok; Chem. Eur. J., 1996, 2, 133 |
| 33. | “Positive-ion electrospray mass spectra for a number of polypeptides and proteins”, M. He, J. Xu, T-W.D. Chan and R.L.C. Lau; Rapid Commun. Mass Spectrom., 1996, 10, 987-902. |
| 34. | “Use of ammonium halides as co-matrices for matrix-assisted laser desorption / ionization studies of oligonucleotides”, S-W. Cheng and T-W.D. Chan; Rapid Commun. Mass Spectrom., 1996, 10, 907-910. |
| 35. | Fourier transform ion cyclotron resonances studies of terpyridine-based polyether dendrimers and their iron(II) metallocomplexes by liquid secondary ion mass spectrometry”, R.L.C. Lau, T-W. D. Chan, I.Y-K. Chan and H.F. Chow; Euro. Mass Spectrom., 1995, 1, 371-380. |
| 36. | “Initial velocities of positive and negative protein molecule-ions produced in matrix-assisted ultraviolet laser desorption using a liquid matrix”, T-W.D. Chan, I. Thomas, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1994, 222, 579. |
| 37. | Design considerations in energy resolved time-of-flight mass spectrometry”, A.E. Giannakopulos, D.J. Reynolds, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. Ion Phys., 1994, 131, 67. |
| 38. | “Threshold fluences for production of positive and negative ions in matrix-assisted laser desorption / ionisation using liquid and solid matrices”, P.Y. Yau, T-W. D. Chan, P.G. Cullis, A.W. Colburn and P.J. Derrick; Chem. Phys. Lett., 1993, 202, 93. |
| 39. | “Suppression of matrix-ions in ultraviolet laser desorption: Scanning electron microscopy and Raman spectroscopy of the solid sample”, T-W.D. Chan, A.W. Colburn, P.J. Derrick, D.J. Derek and M. Bowden; Org. Mass Spectrom., 1992, 27, 188. |
| 40. | “Matrix-assisted laser desorption / ionization using a liquid matrix: Formation of high-mass cluster ions from proteins”, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1992, 27, 53. |
| 41. | “Matrix-assisted ultraviolet laser desorption: Suppression of the matrix peaks”, T-W.D. Chan, A.W. Colburn and P.J. Derrick; Org. Mass Spectrom., 1991, 26, 342. |
| 42. | “Computer-controlled activation of 25µm diameter tungsten wire for field desorption”, T-W. D. Chan, A.W. Colburn and P.J. Derrick; Int. J. Mass Spectrom. and Ion Phys., 1991, 107, 491. |