Neuro-Psychology Laboratory
Brain is the control centre inside a human. It controls our cognition, emotion and behavior. When the brain malfunctions, human will manifest abnormal cognitive functions, emotions, and behaviors. Our laboratory focuses on understanding the abnormal functions associated with brain disorders, and investigates methods to remodel the brain. One major research topic is to integrate the Chinese medical concepts into neuropsychological intervention and cognitive training.
TEAM MEMBERS
Director:
Chan Sui Yin, Agnes
Professor
Department of Psychology
Chinese University of Hong Kong
Email: aschan@cuhk.edu.hk
Research Staff:
Chan Suet Pan, Quin (quin_chan@gmail.com)
Leung Nga Wai, Kathy (kathyleung616@gmail.com)
Chiu Ching Nam, Mark (markchiu206@gmail.com)
Mui Lok Tung, Samantha (samanthamui_717@hotmail.com)
Sze Lai Man, Sophia (lmsze@cuhk.edu.hk)
Students:
Lee Tze Lok (tllee@cuhk.edu.hk)
Tang Yuk Shing, Johnson (johnsontang86@outlook.com)
Address:
Room 347, 3/F, Sino Building, Chung Chi College, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong
Email:
Chan Sui Yin, Agnes is currently a professor at the Department of Psychology of the Chinese University of Hong Kong and the Director of the Chanwuyi Research Center for Neuropsychological Well-Being. She got her undergraduate degree as well as double master's degrees in psychology and social work from the University of Michigan at Ann Arbor. She obtained a doctoral degree in 1995 majoring in clinical neuropsychology from the University of California at San Diego.
Prof. Chan’s research interest has been on clinical neuropsychology and neuropsychological intervention. Her research has been published in Top-ranking journals including Nature, Archive of Neurology, Cancer, Neuropsychology and Journal of Affective Disorder. Her earlier work was focused on a computational modeling predicting the cognitive deterioration of Alzheimer’s disease, and this line of research has earned her two awards from the American Psychological Association and the International Neuropsychology Association. Prof. Chan then continued to study the brain plasticity related to earlier life experience, and this theoretical model was published in Nature and then reported by New York Time, Washing Post, ABC, BBC and other media worldwide. In 2004, Professor Chan was awarded the Early Career Award by the American Psychological Association for her outstanding contribution to research and development in brain science. She was awarded the Outstanding Research Award by the Chinese University of Hong Kong in 2011, and was also awarded as one of the Ten Outstanding Young Persons in Hong Kong in 2003.
Prof. Chan She has held positions several honorary positions including Adjunct Professor at the San Diego State University and the University of Michigan at Ann Arbor, and Consultant to the Alzheimer's Disease Research Center at the University of California at San Diego. She is currently the Associate Editor of Neuropsychology, and was on the editorial board of Journal of the International Neuropsychological Society, and board member of the International Neuropsychological Society. Apart from these honors, Prof. Chan has received invitations to speak around the world, including the Korean National Assembly and Harvard University. Back in her home town, Prof. Chan was the Founding Chairperson of the Hong Kong Neuropsychological Society, Honorary Consultant at the Queen Elizabeth Hospital and the Duchess of Kent Children's Hospital at Sandy Bay, Honorary Professor at the Shantou University in China, and Honorary Professor of the Zhengzhou Children Hospital.
Being a very experienced clinical neuropsychologist herself, Prof. Chan has been providing clinical services for patients with brain disorders for over 20 years, specializing in Alzheimer's disease, autism spectrum disorders, amnesia, stroke, and attention deficit/hyperactivity disorder. While she was in the United States, she had served in the Veterans Affairs San Diego Medical Center, the Sharp Rehabilitation Center in San Diego, and the Alzheimer's disease Research Center. After returning to Hong Kong, Prof. Chan continued her work on patients with brain disorders. Given the limited assessment tools and mind-body intervention suitable for Chinese population, she has developed indigenous clinical instruments and intervention programs for use with the local Chinese population. The Hong Kong List Learning Test and the Chinese version of the Mattis Dementia Rating Scale, that were developed by Prof. Chan, has been two most commonly used clinical neuropsychological tests in Hong Kong. Her other publications (in Chinese) included Four-Principles to Enhance Children's Brain Functioning (Chung Hwa Book Co., 2009), In Search of One's Heart (World Publishing Company, 2009), Dejian Mind-Body Intervention 5th Edition (Chanwuyi Publishing House Limited, 2013) and Shaolin Chanwuyi (Chanwuyi Publishing House Limited, 2009).
Professor Chan is an ardent supporter of the integration of Eastern and Western approaches in developing more effective intervention programs for brain problems. Prof. Chan has passion on Chinese martial arts, and started practicing martial arts at the age of 18, and consequently learned Chanwuyi as a disciple of Master Shi Dejian. She is one of the pioneers in applying Chinese medical philosophy using the Western scientific approach, and has published papers in exploring the effects of different Chinese interventions on patients with brain disorders. For the past several years, she has been conducting a series of scientific research to study the effect of the Dejian Mind-Body Intervention on neurological and psychiatric disorder and the findings are very promising. The Chanwuyi methods have been showed to be effective in improving emotion, physical health and cognition function.
1) NEURO-IMMUNOLOGICAL MODELLING OF AUTISM
The underlying natures of the cognitive impairment associated with autism remain unclear. Our laboratory has been developing a neuro-immunological model for understanding the core autistic symptoms. That is, to investigate the association between the abnormal brain electrical activity pattern and immunological weakness with the impulsive and perseverative behavior and memory problem of autism.
Publication:
Han, Y. M., Cheung, W. K., Wong, C. K., Sze, S. L., Cheng, T. W., Yeung, M. K., & Chan, A. S. (2017). Distinct Cytokine and Chemokine Profiles in Autism Spectrum Disorders. Frontiers in Immunology, 8.
Han, Y. M. Y., Cheung, M. C., Sze, S. L., & Chan, A. (2014). Altered immune function associated with neurophysiological abnormalities and executive function deficits in children with autism. In V. B. Patel, V. R. Preedy, C. Martin (Eds.), The Comprehensive Guide to Autism (pp.1611-1625). New York: Springer.
Han, Y. M. Y., Chan, A. S., Sze, S. L., Cheung, M. C., Wong, C. K., Lam, J. M. K., & Poon, P. M. K. (2013). Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders. Research in Autism Spectrum Disorders, 7, 662-674.
Han, Y., Leung, W., Wong, C. Lam, J., Cheung, M., & Chan, A. (2011). Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism. Research in Autism Spectrum Disorders, 5, 486-494.
2) NEURO-COGNITIVE MODULATION
Based upon the brain plasticity model, we have developed and scientifically studied several neurocognitive modulation methods. A recent investigation is to integrate Chinese Chan medical concept as a possible neuropsychological intervention for individuals with autism, depression, epilepsy, and elderly with memory problems, as well as normal children and adults. Promising results have been reported on the effects of those methods in enhancing brain functions and altering brain electrical activity pattern.
Publication:
Chan, A. S., Cheung, K. Y., Yeung, M. K., & Lee, T. L. (2018). Sustained effects of memory and lifestyle interventions on memory functioning of older adults. Frontiers in Aging Neuroscience, 10, 240.
Chan, A. S., Cheung, W. K., Yeung, M. K., Woo, J., Kwok, T., Shum, D. H., ... & Cheung, M. C. (2017). A Chinese Chan-based Mind-Body Intervention Improves Memory of Older Adults. Frontiers in Aging Neuroscience, 9.
Chan, A. S., Sze, S. L., Woo, J., & Yu, R. H. (2014). A Chinese Chan-based lifestyle intervention improves memory of older adults. Frontiers in Aging Neuroscience, 6, 50, doi:10.3389/fnagi.2014.00050.
Yu, R., Woo, J., Chan, A. S., & Sze, S. L. (2014). A Chinese Chan-based mind-body intervention improves psychological well-being and physical health of community-dwelling elderly: A pilot study. Clinical Interventions in Aging, 9, 727-736.
Chan, A. S., Sze, S. L., & Han, Y. M. Y. (2014). An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism. Research in Autism Spectrum Disorders, 8, 681-691.
Chan, A. S., Han, Y. M. Y., & Cheung, M. C. (2014). Chinese Chan-based prospective neuropsychological intervention for autistic children. In V. B. Patel, V. R. Preedy, & C. R. Martin (Eds.), The Comprehensive Guide to Autism (pp.2333-2355). New York: Springer.
Chan, A. S., Han, Y. M. Y., Sze, S. L., Wong, Q. Y., & Cheung, M. C. (2013). A randomized controlled neurophysiological study of a Chinese Chan-based mind-body intervention in patients with major depressive disorder. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 812096, doi:10.1155/2013/812096.
Chan, A. S., Sze, S. L., Siu, N. Y., Lau, E. M., & Cheung, M. C. (2013). A Chinese mind-body exercise improves self-control of children with autism: A randomized controlled trial. PLoS ONE, 8, e68184.
Chan, A., & Sze, S. L. (2013). Shaolin mind-body exercise as a neuropsychological intervention. In P. C. Leung, J. Woo, & W. Kofler (Eds.), Annals of Traditional Chinese Medicine: Health, Wellbeing, Competence and Aging (pp.201-211). New Jersey: World Scientific Publishing.
Chan, A. S., Wong, Q. Y., Sze S. L., Kwong, P. P. K., Han, Y. M. Y., & Cheung, M. C. (2012). A Chinese Chan-based mind-body intervention for patients with depression. Journal of Affective Disorders, 142, 283-289.
Chan, A., Sze, S. L., Han, Y. M. Y., & Cheung, M. C. (2012). A Chan dietary intervention enhances executive functions and anterior cingulate activity in autism spectrum disorders: a randomized controlled trial. Evidence-based Complementary and Alternative Medicine, 2012, Article ID 262136.
Chan, A., Wong, Q. Y., Sze, S. L., Kwong, P. P. K., Han, Y. M. Y., & Cheung, M. C. (2012). A Chinese Chan-based mind-body intervention improves sleep on patients with depression: a randomized controlled trial. The ScientificWorldJournal, doi:10.1100/2012/235206.
Chan, A. S., Sze, S. L., Cheung, M. C., Han, Y. M., Leung, W. W. & Shi, D. (2011) Dejian mind-body intervention improves the cognitive functions of a child with autism. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2011/549254.
Chan, A. S., Cheung, M. C., Sze, S. L., Leung, W. W. & Shi, D. (2011). Shaolin Dan Tian breathing fosters relaxed and attentive mind: A randomized controlled neuro-electrophysiological study. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2011/180704.
Chan, A., Cheung, M.C., Sze, S., Leung, W. & Shi, D. (2011). An herbal nasal drop enhanced frontal and anterior cingulate cortex activity. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nep198.
Chan, A. S., Cheung, M. C., Tsui, W. J., Sze, S. L. & Shi, D. (2011). Dejian mind-body intervention on depressive mood of community-dwelling adults: a randomized controlled trail. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nep043.
Chan, A., Sze, S., Cheung, M. C., Lam, J. M. & Shi, D. (2009). Dejian mind-body intervention improves the functioning of a patient with chronic epilepsy: a case report. Cases Journal, 2, 9080, doi:10.1186/1757-1626-2-9080.
Chan, A. , Sze, S., & Shi, D. (2008). Traditional Chinese mind-body exercises improve self control ability of an adolescent with Asperger’s disorder. Journal of Psychology in Chinese Societies, 9, 225-239.
3) NEURO-ELECTRICAL NEURAL NETWORK
Our laboratory has utilized electroencephalography (EEG) as a mean to understand the neural processing of various cognitive impairments. For instance, the underlying mechanism of impulse control associated with autism, memory problems associated with aging, and mental status of mood disorder. The coherence of the left-right frontal-posterior hemisphere and the source localization of electrical signals are two major investigating methods.
Publication:
Yeung, M. K., Lee, T. L., & Chan, A. S. (2019). Impaired recognition of negative facial expressions is partly related to facial perception deficits in adolescents with high-functioning autism spectrum disorder. Journal of Autism and Developmental Disorders, 1-11.
Yeung, M. K., Lee, T. L., & Chan, A. S. (2019). Frontal lobe dysfunction underlies the different word retrieval impairment in adolescents with high-functioning autism. Autism Research, 12(4), 600-613.
Han, Y. M., & Chan, A. S. (2017). Disordered cortical connectivity underlies the executive function deficits in children with autism spectrum disorders. Research in Developmental Disabilities, 61, 19-31.
Yeung, M. K., Han, Y. M., Sze, S. L., & Chan, A. S. (2016). Abnormal frontal theta oscillations underlie the cognitive flexibility deficits in children with high-functioning autism spectrum disorders. Neuropsychology, 30(3), 281.
Yeung, M. K., Han, Y. M. Y., Sze, S. L., & Chan, A. S. (2014). Altered right frontal cortical connectivity during facial emotion recognition in children with autism spectrum disorders. Research in Autism Spectrum Disorders, 8, 1567-1577.
Chan, A. S., Sze, S. L., & Han, Y. M. Y. (2014). An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism. Research in Autism Spectrum Disorders, 8, 681-691.
Han, Y. M. Y., Cheung, M. C., Sze, S. L., & Chan, A. (2014). Altered immune function associated with neurophysiological abnormalities and executive function deficits in children with autism. In V. B. Patel, V. R. Preedy, C. Martin (Eds.), The Comprehensive Guide to Autism (pp.1611-1625). New York: Springer.
Chan, A. S., Han, Y. M. Y., & Cheung, M. C. (2014). Chinese Chan-based prospective neuropsychological intervention for autistic children. In V. B. Patel, V. R. Preedy, & C. R. Martin (Eds.), The Comprehensive Guide to Autism (pp.2333-2355). New York: Springer.
Han, Y. M. Y., Chan, A. S., Sze, S. L., Cheung, M. C., Wong, C. K., Lam, J. M. K., & Poon, P. M. K. (2013). Altered immune function associated with disordered neural connectivity and executive dysfunctions: A neurophysiological study on children with autism spectrum disorders. Research in Autism Spectrum Disorders, 7, 662-674.
Chan, A. S., Han, Y. M. Y., Sze, S. L., Wong, Q. Y., & Cheung, M. C. (2013). A randomized controlled neurophysiological study of a Chinese Chan-based mind-body intervention in patients with major depressive disorder. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 812096, doi:10.1155/2013/812096.
Chan, A. S., Sze, S. L., Siu, N. Y., Lau, E. M., & Cheung, M. C. (2013). A Chinese mind-body exercise improves self-control of children with autism: A randomized controlled trial. PLoS ONE, 8, e68184.
Chan, A., Sze, S. L., Han, Y. M. Y., & Cheung, M. C. (2012). A Chan dietary intervention enhances executive functions and anterior cingulate activity in autism spectrum disorders: a randomized controlled trial. Evidence-based Complementary and Alternative Medicine, 2012, Article ID 262136.
Chan, A. S., Sze, S. L., Cheung, M. C., Han, Y. M., Leung, W. W. & Shi, D. (2011) Dejian mind-body intervention improves the cognitive functions of a child with autism. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2011/549254.
Chan, A. S., Cheung, M. C., Sze, S. L., Leung, W. W. & Shi, D. (2011). Shaolin Dan Tian breathing fosters relaxed and attentive mind: A randomized controlled neuro-electrophysiological study. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2011/180704.
Chan, A., Han, W., Leung, W., Leung, C., Wong, V., & Cheung, M. (2011). Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5, 254-266.
Chan, A., Han, Y., Sze, S., Cheung, M. Leung, W., Chan, R & To, C. (2011). Disordered connectivity associated with memory deficits in children with autism spectrum disorders. Research in Autism Spectrum Disorders, 5, 237-245.
Chan, A., Cheung, M.C., Sze, S., Leung, W. & Shi, D. (2011). An herbal nasal drop enhanced frontal and anterior cingulate cortex activity. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nep198.
Chan, A. S., Cheung, M. C., Tsui, W. J., Sze, S. L. & Shi, D. (2011). Dejian mind-body intervention on depressive mood of community-dwelling adults: a randomized controlled trail. Evidence-based Complementary and Alternative Medicine, doi:10.1093/ecam/nep043.
Chan, A., Sze, S., Cheung, M. C., Lam, J. M. & Shi, D. (2009). Dejian mind-body intervention improves the functioning of a patient with chronic epilepsy: a case report. Cases Journal, 2, 9080, doi:10.1186/1757-1626-2-9080.
Chan, A., Cheung, M., Han, Y., Sze, S., Leung, W. Man, H., & To, C. (2009). Executive function deficits and neural discordance in children with Autism Spectrum Disorders. Clinical Neurophysiology, 120, 1107-1115.
Chan, A. S., Han, Y. M., & Cheung, M. C. (2008). Electroencephalographic (EEG) measurements of mindfulness-based triarchic body-pathway relaxation technique: A pilot study. Applied Psychophysiology and Biofeedback, 33, 39-47.
Chan, A. S., Sze, S. L., & Cheung, M. C. (2007). Quantitative electroencephalographic profiles for children with autistic spectrum disorder. Neuropsychology, 21(1), 74-81.
Chan, A. & Leung, W. (2006). Differentiating autistic children with quantitative encephalography: A 3-month longitudinal study. Journal of Child Neurology, 21, 391-399.
Subject Recruitment for Research Project on “Effects of Photoneuromodulation on Cognitive Functions”
Are you experiencing memory problem? Are you often forgetful? Or have you been diagnosed with dementia?
Do you want to try a non-drug and painless experimental treatment?
The Neuropsychology Laboratory of the Department of Psychology, The Chinese University of Hong Kong collaborates with the Harvard University in the United States to investigate the effects of photoneuromodulation on functional activity and executive functions of adult brains. The research project "Effectsof Photoneuromodulation on Cognitive Functions" is based on the recent research results in the United States and is currently conducted in Hong Kong.
Target participants are adults who are over forty years old and had suffered or are suffering from brain disorders including dementia, brain trauma, etc. Interested parties are hereby invited to participate free of charge.
The study begins in September and the details are as follows:
- Participants will be administered neuropsychological tests that measure brain activity.
- After the test, the participants will receive treatment twice per week, about thirty minutes each time. We will fix a photoneuromodulation device onto the participant's head. Such treatment will not cause any pain and has no adverse effect.
- After completing all treatments, the participants will be administered the neuropsychological tests again and receive a verbal report on their progress.
If you are interested in participating in this study, or would like to learn more, please contact Miss Mui at 3943-6648 or WhatsApp 6535-9909. You may also complete and submit the online enrolment form (click here: https://forms.gle/9TbBU1EJgB1CtgY27).
After screening, participants will receiveour call to confirm appointment for assessment and treatment.
「低能量紅外光對認知功能效用」招募研究參加者
你是否感到無記性? 常常健忘? 或已確診患腦退化症?
你希望嘗試一種非藥物及無痛的實驗治療嗎?
香港中文大學心理學系腦智能研究室與美國哈佛大學合作項目, 旨在了解低能量紅外光技術(Photoneuromodulation) 對成人的大腦運作和執行功能的影響。「低能量紅外光對認知功能效用」的研究計劃是基於美國新近研究成果在香港進行實驗。
研究對象為四十歲以上，曾經或現正患有腦疾病，包括腦退化、腦創傷等。特此誠邀有興趣人士免费參與。
研究於九月開始，活動內容如下：
- 參加者將會參與一些量度大腦活躍程度的腦功能測試。
- 測試後，參加者開始接受治療，每星期兩次。每次大約三十分鐘。我們會在參加者的頭部放置低能量紅外光儀器，該儀器不會有任何疼痛，也不會對身體產生不良的影響。
- 完成所有療程後，參加者會再次進行大腦功能測試，並獲得口述的進度報告。
如果有興趣參加是次研究，或想進一步了解詳情，請致電3943-6648 或whatsapp 65359909 聯絡梅小姐。你亦可填妥及遞交網上報名表（請按此: https://forms.gle/9TbBU1EJgB1CtgY27）。
通過篩選後，參加者將收到個別聯絡，相約活動日期和時間。
Chan, A., Butters, N., Paulson, J., Salmon, D., Swenson, M. & Maloney, L. (1993). An assessment of the semantic network in patients with Alzheimer's disease. Journal of Cognitive Neuroscience, 5, 254-261.
Chan, A., Butters, N., Salmon, D., & McGuire, K. (1993). Dimensionality and clustering in the semantic network of patients with Alzheimer's disease. Psychology and Aging, 8, 411-419.
Chan, A., Butters, N., Salmon, D., & McGuire, K. (1993). Semantic space of patients with Alzheimer's disease and Huntington’s disease. Journal of Clinical and Experimental Neuropsychology, 15, 38.
Chan, A., Butters, N., Salmon, D., Johnson, S., Paulson, J., & Swenson, M. (1995). Comparison of the semantic network in patients with dementia and amnesia. Neuropsychology, 9, 177-186.
Chan, A., Butters, N., Salmon, D., & Johnson, S. (1995) Semantic network abnormality predicts rate of cognitive decline in patients with probable Alzheimer's disease. Journal of the International Neuropsychological Society, 1, 297-303.
Paulsen, J. S., Romero, R., Chan, A., Davis, A. V., Heaton, R. K., & Jeste, D. V. (1996). Impairment of the semantic network in schizophrenia. Psychiatry Research, 63, 109-121.
Chan, A., Butters, N., & Salmon, D. (1997). The deterioration of semantic networks in patients with Alzheimer's disease: A cross-sectional study. Neuropsychologia, 35, 241-248.
Heindel, W., Salmon, D., Fennema-Notestine, C., & Chan, A. (1998). Repetition priming with nonverbal stimuli in patients with dementia of the Alzheimer type. Neuropsychology, 12, 43-51.
Chan, A., Ho, Y. C., & Cheung, M. C. (1998). Music training improves verbal memory. Nature, 396, 128.
Chan, A., Salmon, D., Nordin, S., Murphy, C., & Razani, J. (1998). Abnormality of semantic network in patients with Alzheimer’s disease: Evidence from verbal, perceptual and olfactory domains. Annals of the New York Academy of Sciences, 855, 681-685.
Chan, A., Salmon, D., & DeLaPena, J (1999). Conceptual and perceptual contributions to the acquisition and retention of text-specific reading skill in Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 21, 325-340.
Chan, A., & Wong, M. (1999). Performance of 7- to 95-year-old individuals in a Chinese version of the category fluency test. Journal of the International Neuropsychological Society, 5, 525-533.
Chan, A., Chiu, H., Lam, L., Pang, A., & Chow, L. Y. (1999). A breakdown of event schemas in patients with schizophrenia: An examination of their script for dining at restaurants. Psychiatry Research, 87, 169-181.
Cheung, M., Chan, A. S., Law, S., Chan, J., Tse, V., & Kong H. (1999). Cognitive functions of patients with and without MRI evidence of temporal lobe lesions after radiotherapy for their nasopharyngeal carcinoma. Neurology, 52, A200.
Ho, H S., Chan, A. S., Poon, W. S., & Wong, C. W. (1999). Comparison of neuropsychological sequelae of microsurgical clipping and endovascular embolization as treatments for ACoA aneurysms. Neurology, 52, A240-A241.
Salmon, D., Butters, N., & Chan, A. (1999). The deterioration of semantic memory in Alzheimer's disease. The Canadian Journal of Experimental Psychology, 53, 108-116.
Chan, A., Kwok, I., Chui, H., Lam, L., Pang, A., & Chow, L. Y. (2000). Memory and organizational strategies in chronic and acute schizophrenic patients. Schizophrenia Research, 41, 431-445.
Chan, A., Cheung, M. C., Ho, Y. C., & He, W. J. (2000). Localized brain activation by selective tasks improves specific cognitive functions in humans. Neuroscience Letters, 283, 162-164.
Cheung, M. C., Chan, A., Law, S., Chan, J., & Tse, V. (2000). Cognitive function of patients with nasopharyngeal carcinoma with and without temporal lobe radionecrosis. Archives of Neurology, 57, 1347-1352.
Chan, A., Salmon, D., & DeLaPena, J. (2001) Abnormal semantic network for “animals” but not “tools” in patients with Alzheimer’s disease. Cortex, 37, 197-217.
Chan A., Choi M. K., & Salmon D. P. (2001). The effect of age, education, and gender on the Mattis Dementia Rating Scale performance of Chinese and American elderly. Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 56B, 6, 356-363.
Cheung, M. C., Chan, A. S., Chan, Y. L., Yeung, D. K. W., Lam, J. M. K., He, W. J., & Chung, M. C. B. (2001). Variations in memory performance: Hippocampal versus frontal involvement. NeuroImage, 13, 648.
Chan, A., Ho, S., & Poon, W. S. (2002) Neuropsychological sequelae of patients treated with microsurgical clipping or endovascular embolization for anterior communicating artery aneurysm. European Neurology, 47, 37-44.
Chan, A., Tam, J., Murphy, C., Chiu, H., & Lam, L. (2002). Utility of olfactory identification test for diagnosing Chinese patients with Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 24, 251-259.
Bondi, M. W., Serody, A. B., Chan, A. S., Eberson-Shumate, S. C., Delis, D. C., Hansen, L. A., & Salmon, D. P. (2002). Cognitive and neuropathologic correlates of Stroop color-word test performance in Alzheimer’s disease. Neuropsychology, 16, 335-343.
Guo, Q. H., Lu, C. Z., Chan, S. Y., Hong, Z. Dong, Q. (2002). Research of auditory verbal memory impairment following stroke of different subcerebral structures. Chinese Journal of Clinical Psychology, 10, 81-84. [in Chinese]
Cheung, M. C., & Chan, (2003). Memory impairment in humans after bilateral damage to lateral temporal neocortex. Neuroreport, 14, 371-374.
Chan, A., Choi, A., Chiu, H., & Lam, L. (2003). Clinical validity of the Chinese version of Mattis Dementia Rating Scale in differentiating dementia of Alzheimer’s type in Hong Kong. Journal of the International Neuropsychological Society, 9, 45-55.
Au, A., Chan, A., & Chui, H. (2003). Verbal learning in Alzheimer’s dementia. Journal of the International Neuropsychological Society, 9, 363-375.
Cheung, M. C., Chan, A., Law, S. C., Chan, J. H., & Tse, V. K. (2003). Impact of radionecrosis on cognitive dysfunction in patients following radiotherapy for nasopharyngeal carcinoma. Cancer, 97, 2019-2026.
Cheung, M. C., Chan, A., Law, S. C., Chan, J. H., & Tse, V. K. (2003). Alpha-tocopherol (vitamin E) improves the cognitive functions of patients with radionecrosis. Neurology, 60, A20.
Chan, A., He, W. J., Cheung, M. C., Bai, Z. K., Poon, W. S., Sun, D., Zhu, X. L., & Chan Y. L (2003). Cutaneous stimulation improves function of a chronic patient with cerebellar damage. European Journal of Neurology, 10, 265-269.
Chan, A., & Ho, Y. C. (2003). Things aren’t as bad as they seem: A comment on Storms et al. (2003). Neuropsychology, 17, 247-254.
Ho, Y. C., Cheung, M. C., & Chan, A. (2003). Music training improves verbal but not visual memory: Cross-sectional and longitudinal explorations in children. Neuropsychology, 12, 439-450.
Au, A., Chan, A. S., & Chiu, H. (2003). Conceptual organization in Alzheimer’s dementia. Journal of Clinical and Experimental Neuropsychology, 25, 737-750.
Chan, A., Shum, D., & Cheung, R. (2003). Recent development of cognitive and neuropsychological assessment in Asian countries. Psychological Assessment, 15, 257-267.
Woo, J., Lau, E., Ho, S.C., Cheng, F., Chan, C., Chan A. S., Haines, C. J., Chan, T. Y. K., Li, M., & Sham, A. (2003). Comparison of pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause, 10, 352-361.
Cheung, R., Cheung, M. C., & Chan, A. (2004). Confrontation naming in Chinese patients with left, right and bilateral brain damage. Journal of the International Neuropsychological Society, 10, 46-53.
Chan, A., Cheung, M. C., Law, S. C., & Chan, J. H., (2004). Phase II study of Alpha-Tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis. Cancer, 100, 398-404.
Wong, A., Mok, V. C., Yim, P., Fu, M., Lam, W. W., Hui, A. C., Yau, C., Chan, A. S., & Wong, K. S. (2004). The executive clock drawing task (CLOX) is a poor screening test for executive dysfunction in Chinese elderly patients with subcortical ischemic vascular disease. Journal of Clinical Neuroscience, 11, 493-497.
Chan, A., Sze, S. & Cheung, M. C. (2004). Neuroanatomical basis in the temporal lobe in processing living things. Neuropsychology, 18, 700-709.
Cheung, M. C., Chan, A., Chan, Y., Lam, J. M., & Cheung, R. W. (2004). Naming impairment in the Chinese patients with left temporal lobe epilepsy: A fMRI study. Archives of Clinical Neuropsychology, 19, 940.
Ho, Y., & Chan, A. (2004). Comparing the effects of Chinese national tile game and reading on the cognitive reserve of the elderly. Archives of Clinical Neuropsychology, 19, 976.
Ho, Y., & Chan, A. (2005). Comparing the effects of mahjong playing and reading on cognitive reserve of the elderly. Journal of Psychology in Chinese Societies, 6, 5-26.
Chan, A., Cheung, J., Leung, W. M., Cheung, R. & Cheung M. C. (2005). Verbal expression and comprehension deficits in young children with autism. Focus on Autism and Other Developmental Disabilities, 2, 117-124.
Chan, A., Ho, Y., Cheung, M., Albert, M., Chiu, H. & Lam, L. (2005). Association between mind-body and cardiovascular exercises and memory in older adults. Journal of American Geriatrics Society, 53, 1754-1760.
Chan, A. (2005). Asian cross cultural issues in diagnosing dementia. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 1, S106-S107.
Chan, A. & Leung, W. (2006). Differentiating autistic children with quantitative encephalography: A 3-month longitudinal study. Journal of Child Neurology, 21, 391-399.
Chan, A. (2006). Conducting functional magnetic resonance imaging studies on children: An adaptive process. Journal of Bio-education, 1, 50-53.
Chan, A., Cheung, M. C., Chan, Y. L., Yeung, D. K., & Lam, W. (2006). Bilateral frontal activation associated with cutaneous stimulation of elixir field: An fMRI study. American Journal of Chinese Medicine, 34, 207-216.
Cheung, M. C., Chan, A. S., Chan, Y. L., Lam, J. M., & Lam, W. (2006). Effects of illness duration on memory processing of patients with temporal lobe epilepsy. Epilepsia, 47, 1320-1328.
Cheung, M. C., Chan, A. S., Chan, Y. L., & Lam, J. M. (2006). Language lateralization of Chinese-English bilingual patients with temporal lobe epilepsy: a functional MRI study. Neuropsychology, 20(5), 589-597.
Chan, A. S., & Cheung, M. C. (2007). Pre-activating the mesial temporal lobe facilitates learning. Neuroscience Letters, 411, 194-199.
Cheung, M.C., & Chan, A.S., (2010). fMRI activation associated with brand names: A category of proper nouns. Clinical Neurophysiology, 120, S210.
Cheung, M.C., & Chan, A.S., (2010). Change in EEG activity associated with positive mood change after cutaneous stimulation over Shenmen. Clinical Neurophysiology, 121, S245.
Cheung, M.C., Chan, A.S., Wu, J., & Sze, S. L. (2010). Micro-current electrical stimulation at bilateral wrist hand area facilitates changes in EEG activities associated with reduction in arousal: A randomized controlled trial. International Journal of Psychophysiology, 77, 319.
Chan, A. S., Sze, S. L., Cheung, M. C., Han, Y. M., Leung, W. W. & Shi, D. (2011) Dejian mind-body intervention improves the cognitive functions of a child with autism. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2011/549254
Chan, A., Wong, Q. Y., Sze, S. L., Kwong, P. P. K., Han, Y. M. Y., & Cheung, M. C. (2012). A Chinese Chan-based mind-body intervention improves sleep on patients with depression: a randomized controlled trial. The ScientificWorldJournal, doi:10.1100/2012/235206
Chan, A., Sze, S. L., Han, Y. M. Y., & Cheung, M. C. (2012). A Chan dietary intervention enhances executive functions and anterior cingulate activity in autism spectrum disorders: a randomized controlled trial. Evidence-based Complementary and Alternative Medicine, 2012, 262136.
Chan, A. S., Sze, S. L., & Han, Y. M. (2014). An intranasal herbal medicine improves executive functions and activates the underlying neural network in children with autism. Research in Autism Spectrum Disorders, 8(6), 681-691.
Cheung, M. C., Chan, A. S., & Yip, J. (2015). Microcurrent stimulation at Shenmen acupoint facilitates EEG associated with sleepiness and positive mood: a randomized controlled electrophysiological study. Evidence-Based Complementary and Alternative Medicine, 2015, 182837.
Han, Y. M. Y., Sze, S. L., Wong, C. K., & Chan, A. S. (2015). Intranasal Borneol Improves the Behavioral Problems and Enhances the Immunologic Function in Children with Autism. J Pharmacogn Nat Prod, 1, 114.
Chan, A. S., Sze, S. L., Cheung, M. C., & Han, Y. M. (2016). Development and application of neuropsychology in Hong Kong: implications of its value and future advancement. The Clinical Neuropsychologist, 30(8), 1236-1251.
Yeung, M. K., Han, Y. M., Sze, S. L., & Chan, A. S. (2016). Abnormal frontal theta oscillations underlie the cognitive flexibility deficits in children with high-functioning autism spectrum disorders. Neuropsychology, 30(3), 281.
Yeung, M. K., Sze, S. L., Woo, J., Kwok, T., Shum, D. H., Yu, R., & Chan, A. S. (2016). Altered frontal lateralization underlies the category fluency deficits in older adults with mild cognitive impairment: a near-infrared spectroscopy study. Frontiers in aging neuroscience, 8.
Yeung, M. K., Sze, S. L., Woo, J., Kwok, T., Shum, D. H., Yu, R., & Chan, A. S. (2016). Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy. Dementia and Geriatric Cognitive Disorders, 42(5-6), 278-296.
Han, Y. M., & Chan, A. S. (2017). Disordered cortical connectivity underlies the executive function deficits in children with autism spectrum disorders. Research in Developmental Disabilities, 61, 19-31.
Han, Y. M., Cheung, W. K., Wong, C. K., Sze, S. L., Cheng, T. W., Yeung, M. K., & Chan, A. S. (2017). Distinct Cytokine and Chemokine Profiles in Autism Spectrum Disorders. Frontiers in Immunology, 8.
Cheung, M. C., Chan, A. S., Liu, Y., Law, D., & Wong, C. W. (2017). Music training is associated with cortical synchronization reflected in EEG coherence during verbal memory encoding. PloS one, 12(3), e0174906.
Chan, A. S., Cheung, W. K., Yeung, M. K., Woo, J., Kwok, T., Shum, D. H., ... & Cheung, M. C. (2017). A Chinese Chan-based Mind-Body Intervention Improves Memory of Older Adults. Frontiers in Aging Neuroscience, 9.
Yeung, M. K., Lee, T. L., Cheung, W. K., & Chan, A. S. (2018). Frontal underactivation during working memory processing in adults with acute partial sleep deprivation: a near-infrared spectroscopy study. Frontiers in Psychology, 9.
Chan, A. S., Cheung, K. Y., Yeung, M. K., & Lee, T. L. (2018). Sustained effects of memory and lifestyle interventions on memory functioning of older adults. Frontiers in Aging Neuroscience, 10, 240.
Chan, A. S., Lee, T. L., Yeung, M. K., & Hamblin, M. R. (2019). Photobiomodulation improves the frontal cognitive function of older adults. International Journal of Geriatric Psychiatry, 34(2),369-377.
Yeung, M. K., Lee, T. L., & Chan, A. S. (2019). Impaired recognition of negative facial expressions is partly related to facial perception deficits in adolescents with high-functioning autism spectrum disorder. Journal of Autism and Developmental Disorders, 1-11.
Yeung, M. K., Lee, T. L., & Chan, A. S. (2019). Frontal lobe dysfunction underlies the different word retrieval impairment in adolescents with high-functioning autism. Autism Research, 12(4), 600-613.
Salmon, D. P., & Chan, A. S. (1994). Semantic memory deficits associated with Alzheimer’s disease. In: L. S. Cermak (Ed.) Neuropsychological Explorations of Memory and Cognition: Essays in Honor of Nelson Butters (pp. 61-76). New York: Plenum Press.
Salmon, D., & Chan, A. (1995). Semantic memory in Alzheimer's disease patients. In L. S. Cermak (Ed). Neuropsychological explorations of memory and cognition: Essays in honor of Nelson Butters. New York: Plenum Press.
Chan, A., Butters, N., & Salmon, D. (1998). Semantic networks abnormality of patients with Alzheimer's disease (p 381-393). In R. W. Parks, D. S. Levine & D. L. Long (Eds). Fundamentals of neural network modeling: Neuropsychology and cognitive neuroscience, Mass: MIT Press.
Chan, A., & Kwok, I. (1999). The Hong Kong List Learning Test: Manual and preliminary norm. Department of Psychology: CUHK
Chan, A., Poon, M., Choi, A., & Cheung, M.C. (2002) Chinese version of the Mattis Dementia Rating Scale. Psychological Assessment Resources: Florida.
Chan, A. (2006). The Hong Kong List Learning Test (2nd Edition). Department of Psychology: CUHK.
Chan, A. Cheung, M.C., & Sze, S. L. (2008). Effect of mind-body training on children with behavioral and learning problems: A randomized controlled study. In F. Columbus (Eds.), Mind-body and Relaxation Research Focus . NOVA Science Publishers.
Chan, A. S., Leung, W. W., & Cheung, M. C. (2010). Clinical neuropsychology in China. In M. H. Bond (Ed.), The Oxford Handbook of Chinese Psychology (pp.383-398). New York: Oxford University Press.
Chan, A. S. (2010). The Shaolin Chanwuyi: A Chinese Chan Buddhism. Hong Kong: Chanwuyi Publishing.
Chan, A. S., Leung, W. W., & Cheung, M. C. (2011). Neuropsychology in China. In D. E. M. Fujii (Ed.), Neuropsychology of Asian Americans (pp.201-217). London: Taylor & Francis.
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Neuropsychology, as a branch of psychology and neurology, is a science studying the relationship between the human brain and behaviors. The main objective of neuropsychology is to understand specific psychological processes and behaviors of human being from the perspective of the structure and function of the brain. It is scientific in its approach and shares an information processing view of the mind with cognitive psychology and cognitive science.
“The brain controls all of our thoughts, feelings and behaviors”. This notion was not generally agreed in the history of when neuropsychology began to emerge. The origin of the development in neuropsychology can be traced back to around 3500 B.C. in ancient Egypt, when Imhotep, one of the first physicians recorded in history, began to study functions of the brain scientifically. Nevertheless, by that time, the brain was still looked upon as a useless organ and was generally discarded during burial processes and autopsies. People at that time tended to explain human body function from a religious point of view and attribute any abnormalities to bad spirits and the gods. The brain has not always been looked upon as the center for the functioning body as we know it to be now; rather, it has taken hundreds of years for the hundreds of great minds committed to their scientific investigation for the discovery of our brain’s functions and its relations to our behaviors.
Neuropsychology can be seen as an experimental and clinical field of psychology that aims to study, assess, understand and treat behaviors directly related to brain functioning. The major difference between experimental and clinical neuropsychology is that the prior involves studying healthy humans with experimental psychology approach to understand human brain functions in a laboratory setting, whereas the latter applies neuropsychological knowledge to the assessment, management and rehabilitation of people with brain disorders in clinical settings or as an expert witness in medico-legal proceedings. Some experimental neuropsychologists would also conduct animal studies. By integrating with a psychological point of view to the treatment for brain disordered patients, a clinical neuropsychologist can understand how the brain disorder may affect and be affected by psychological factors, and thereby determine whether a person is demonstrating difficulties attributed to the brain pathology or simply a psychological reaction or both. Another sub-division of neuropsychology is termed as cognitive neuropsychology, which is an approach composing the elements of both experimental and clinical neuropsychology. Cognitive neuropsychology studies the behaviors of people who have sustained brain injury or neurological disorders to understand human brain functions, with the basic principle that a specific part of the brain is in some way involved in certain cognitive function if that cognitive function becomes impaired after that specific brain region get injured.
“The brain controls all of our thoughts, feelings and behaviors”. This notion was not generally agreed in the history of when neuropsychology began to emerge. The origin of the development in neuropsychology can be traced back to around 3500 B.C. in ancient Egypt, when Imhotep, one of the first physicians recorded in history, began to study functions of the brain scientifically. Nevertheless, by that time, the brain was still looked upon as a useless organ and was generally discarded during burial processes and autopsies. People at that time tended to explain human body function from a religious point of view and attribute any abnormalities to bad spirits and the gods. The brain has not always been looked upon as the center for the functioning body as we know it to be now; rather, it has taken hundreds of years for the hundreds of great minds committed to their scientific investigation for the discovery of our brain’s functions and its relations to our behaviors.
In whatever aspects of neuropsychology, structure and function of the brain can be assessed by the following widely adopted methods and tools:
1) Standardized Neuropsychological Tests:
Neuropsychological tests are mostly paper-and-pencil tests that have been developed based upon the understanding of brain-behavior relationship and typically validated and standardized with a specific group (or groups) of individuals before being used in individual clinical cases. These tests are designed such that the performance on the tests can reflect the condition of specific neurocognitive processes. Some well-known examples of neuropsychological tests include the Halstead-Reitan Neuropsychological Battery, the Boston Naming Test, the California Verbal Learning Test, and the Wisconsin Card Sorting Test. Given that majority of the neuropsychological tests is developed for the Western societies, while some of them are limited by the language and cultural factors that they can hardly be applied to the Asian populations, therefore, some researchers have devoted to translating existing neuropsychological tests or developing new tests for the Asians. Our laboratory has also developed several neuropsychological tests with clinical validation for the Chinese people, such as the Hong Kong List Learning Test (a test for verbal memory function), the Chinese version of Dementia Rating Scale (a test for dementia), a modified version of the Boston Naming Test (a test for naming ability), the verbal fluency test (a test for fluent speech production), which have been widely adopted in local allied-health institutes and universities in Hong Kong and mainland China.
2) Brain Scans:
Various brain scanning methods can be used for examining the structure or function of the brain. These methods are simply a way to assess the brain structure with high resolution pictures or to assess the relative activations of different brain areas. The techniques for examining the structure of the brain include computed axial tomography (CAT or CT) and magnetic resonance imaging (MRI); whereas techniques for assessing the function of the brain include functional magnetic resonance imaging (fMRI), positron emission tomography (PET), electroencephalography (EEG) and magneto-encephalography (MEG).
3) Experimental Tasks
The experimental tasks used in neuropsychology are often computerized and typically measuring the reaction time and accuracy on the experimental paradigm that is believed to be related to a specific neurocognitive process. These tasks are also usually implemented while the research participants are undergoing some brain scanning procedures, such as fMRI, PET, EEG, MEG. This is to examine how the brain works when a person is undergoing certain cognitive process so as to tease out functions specific to certain brain region or a network of various parts of the brain.
Dementia Rating Scale (DRS) Chinese Version
Translator: Chan Sui Yin, Poon Wai Lin, Choi Ming Kwan, Cheung Mei Chun
Publisher: The Chinese University of Hong Kong
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Dementia Rating Scale (DRS) Chinese Version CD
Author: Chan Sui Yin
Publisher: The Chinese University of Hong Kong
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Hong Kong List Learning Test(HKLLT) 2nd Edition
Author: Chan Sui Yin
Publisher: The Chinese University of Hong Kong
Address: Room 347, 3/F, Sino Building, Chung Chi College, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong
Tel: (+852) 3943-4166
E-mail: info.crc@cuhk.edu.hk