RESEARCH INTERESTS:

• Chemical and molecular biology tools for studying neuropsychiatric diseases
• Molecular and circuitry mechanisms of normal and pathological brain functioning
• Biomarkers for neuropsychiatric diseases
• Neuropsychopharmacology

AWARDS:

• 46th International EXhibitions of Inventions Geneva, Switzerland, Gold Medal Award

CURRENT PROJECTS:

• Advanced human and animal brain tissue research methods
• Biomarker discovery in psychiatric diseases

SELECTED PUBLICATIONS:

1. Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM. Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues. Nat Commun. 2018; 9:1066.

2. Lai HM, Ng WL, Gentleman SM, Wu W. Chemicals Probes for Visualizing Intact Animal and Human Brain Tissue. Cell Chem Biol 2017; 24:659-672.

3. Liu AKL, Lai HM, Chang RC, Gentleman SM. Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues. Neuropathol Appl Neurobiol. 2016; 43:346-351.

4. Lai HM, Liu AKL, Ng WL, DeFelice J, Lee WS, Li H, Li W, Ng HM, Chang RCC, Lin B, Wu W, Gentleman SM. Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging. PLoS One. 2016; 11:e0158628.