Associate Professor
Room 360 Science Centre
(852) 3943 6165
(852) 2603 5057
jiangxia@cuhk.edu.hk
Education
| 1999 | B.Sc. | Nanjing University |
| 2002 | M.S. | Nanjing University |
| 2006 | Ph.D. | Stanford University |
Position
| Since 2015.4 | Associate Professor (by courtesy), School of Life Sciences, The Chinese University of Hong Kong |
| Since 2014.12 | Associate Professor, Department of Chemistry, The Chinese University of Hong Kong |
| 2008.12-2014.12 | Assistant Professor, The Chinese University of Hong Kong |
| 2007-2008 | Research Associate, Howard Hughes Medical Institute |
| 2007-2008 | Postdoctoral scholar, California Institute of Technology |
Research Interests
Chemical biology and synthetic biology
— with a focus on subcellular structures, such as organelles and protein coacervates, and their biocatalytic and biomedical applications.
| 1. | Protein reactions: site-selective protein reactions (cysteine, tyrosine to lysine reactions); reactions of proteins, enzymes, antibodies to organelles |
| 2. | Protein assembly: multienzyme complexes, synthetic metabolon and synthetic organelles |
| 3. | Protein biomaterials: cartilage and skin regeneration and anti-infection |
Selected Publications
| 1 | “Exosome-mediated drug delivery for cell-free therapy of osteoarthritis” Duan, L*.; Xu, X.; Xu, L.; Chen, H.; Li, X.; Alahdal, M.; Xiao, Y.; Liang, Y.*; Xia, J.* Curr. Med. Chem. 2020, DOI: 10.2174/0929867327666201118161232. |
| 2 | “Exosome-Mediated Delivery of Kartogenin for Chondrogenesis of Synovial Fluid-Derived Mesenchymal Stem Cells and Cartilage Regeneration” Xu, X.; Liang, Y.; Li, X.; Ouyang, K.; Wang, M.; Cao, T.; Li, W.; Liu, J.; Xiong, J.; Li, B.; Xia, J.*; Wang, D.*; Duan, L.* Biomaterials, 2020, doi.org/10.1016/j.biomaterials.2020.120539. |
| 3 | “Antibacterial photodynamic peptides for staphylococcal skin infection” Lei, X.; Qiu, L.; Lan, M.; Du, X.; Zhou, S.; Cui, P.; Zheng, R.; Jiang, P.*; Wang, J.*; Xia, J.* Biomater. Sci. 2020 DOI: 10.1039/D0BM01467B |
| 4 | “Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo” Wei, Q.; He, S.; Qu, J.; Xia, J.* Bioconjugate Chem. 2020 doi: 10.1021/acs.bioconjchem.0c00476 |
| 5 | “An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance” Xiao, X.; Zhang, S.; Chen, S.; Qian, Y.; Xie, J.; Cong, Z.; Zhang, D.; Zou, J.; Zhang, W.; Ji, Z.; Cui, R.; Qiao, Z.; Jiang, W.; Dai, Y.; Wang, Y.; Shao, X.; Sun, Y.; Xia, J.; Fei, J.; Liu, R. Biomater. Sci. 2020 doi: 10.1039/d0bm01211d |
| 6 | “Bacteriophage-derived Endolysins to Target Gram-Negative Bacteria” Lai, W. C. B.; Chen, X.; Ho, M. K. Y.; Xia, J.; Leung, S. S. Y. Int. J. Pharmaceutics 2020, 589, 119833 |
| 7 | “Mesenchymal Stem Cell − Derived Exosomes for Treatment of Autism Spectrum Disorder” Liang, Y.; Duan, L.; Xu, X.; Li, X.; Liu, M.; Chen, H.; Lu, J.*; Xia, J.* ACS Appl. Bio Mater. 2020, 3, 6384−6393. |
| 8 | “Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy” Liang, Y.; Xu, X.; Li, X.; Xiong, J.; Li, B.; Duan, L.*; Wang, D.*; Xia, J.* ACS Appl. Mater. Interfaces 2020, 12, 36938–36947 |
| 9 | “Host–guest protein assembly for affinity purification of methyl-lysine proteomes” Li, L.; Liu, M.; Yue, L.; Wang, R.; Zhang, N.; Liang, Y.; Zhang, L.; Cheng, L.*; Xia, J.*; Wang, R.* Anal. Chem. 2020. doi.org/10.1021/acs.analchem.0c01643 (Link) |
| 10 | “Phase-separated multienzyme biosynthesis” Liu, M.; He, S.; Cheng, L.; Qu, J.; Xia, J.* Biomacromolecules, 2020, doi.org/10.1021/acs.biomac.0c00321. (Link) |
| 11 | “Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism” Qiu, J.; Nie, Y.; Zhao, Y.; Zhang, Y.; Li, L.; Wang, R.; Wang, M.; Chen, S.; Wang, J.*; Li, Y.Q.*; Xia, J.* Proc. Natl. Acad. Sci. U. S. A. 2020, 117, 5260-5268. (Link) |
| 12 | “On-Resin Passerini Reaction towards C-Terminal Photocaged Peptides” So, W. H.; Xia, J.* Organic Lett. 2020, 22, 214-218. (Link) |
| 13 | “Self-Assembled Multi-Enzyme Nanostructures on Synthetic Protein Scaffolds” Liu, Z.; Cao, S.; Liu, M.; Kang, W.; Xia, J.*. ACS Nano 2019, 13, 11343-11352. |
| 14 | “Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux” Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L.; He, S.; Qu, J.; Au, S. W-N.; Kang, B. H.; Lau, W. C. Y.; Deng, Z.; Xia, J.*, Liu, T.*. Nat. Commun. 2019, 10, 4248. (Link) |
| 15 | “Synthetic Multienzyme Complexes, Catalytic Nanomachineries for Cascade Biosynthesis In Vivo.” Qu, J., Cao, S., Wei, Q., Zhang, H., Wang, R., Kang, W., Ma, T., Zhang, L., Liu, T., Au, W-N. S., Sun, F., Xia, J.*. ACS Nano 2019, 13, 9895-9906. (Link) |
| 16 | “Magnetic enhancement of chondrogenic differentiation of mesenchymal stem cells” Huang, J.; Liang, Y.; Huang, Z.; Zhao, P.; Liang, Q.; Liu, Y.; Duan, L.; Liu, W.; Zhu, F.; Bian, L.; Xia, J.*, Xiong, J.;* Wang, D.* ACS Biomaterials Science & Engineering, 2019, 5, 2200-2207. (Link) [Featured on Supplementary Cover]. |
| 17 | “Site-selective lysine reactions guided by protein-peptide interaction” Zhang, Y.; Liang, Y.; Huang, F.; Zhang, Y.; Li, X.; Xia, J.* Biochemistry. 2019, 58, 1010-1018. (Link) |
| 18 | “Affinity purification of methyllysine proteome by site-specific covalent conjugation” Wang, R.; Huang, M.; Li, L.; Kaneko, T.; Voss, C.; Zhang, L.*; Xia, J.*; Li, S. S. C.* Anal. Chem. 2018, 90, 13876-13881. (Link) |
| 19 | “Reverse binding mode of phosphotyrosine peptides with SH2 protein” Wang, R.; Leung, P. Y. M.; Huang, F.; Tang, Q.; Kaneko, T.; Huang, M.; Li, Z.; Li, S. S. C.*; Wang, Y.*; Xia, J.* Biochemistry 2018, 57, 5257-5269. (Link) |
| 20 | “Syntenin-targeted peptide blocker inhibits progression of cancer cells” Liu, J.; Qu, J.; Zhou, W.; Huang, Y.; Jia, L.; Huang, X.; Qian, Z.; Xia, J.*; Yu. Y.* Eur. J. Med. Chem. 2018, 154, 354-366. (Link) |
| 21 | “A proximity-induced covalent fluorescent probe for selective detection of bromodomain 4” Feng, L.; Chhabra, M.; So, W. H.; Zhu, Q.; Xia, J.*; Sun, H.* Chin. Chem. Letters, 2018, 29, 1147-1150. (Link) |
| 22 | “Peptide photocaging: a brief account of the chemistry and biological applications” So, W. H.; Wong, C. T. T.; Xia, J.* Chin. Chem. Letters, 2018, 29, 1058-1062 (Invited review). (Link) |
| 23 | “Versatile site-selective protein reaction guided by WW domain–peptide motif interaction” Liu, M.; Ji, Z.; Zhang, M.; Xia, J.* Bioconjugate Chem., 2017, 28, 2199-2205. (Link) |
| 24 | “Site-selective covalent reactions on proteinogenic amino acids” So, W. H.; Zhang, Y.; Kang, W.; Wong, C. T. T.*; Sun, H.*; Xia, J.* Curr. Opin. Biotech. 2017, 48, 220–227 (Link) (Invited review). |
| 25 | “Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells” Yu, Y.; Nie, Y.; Feng, Q.; Qu, J.; Wang, R.; Bian, L.; Xia, J.* Mol. Pharmaceutics, 2017, 14, 1548−1557. (Link) |
| 26 | “Thiol-ether Stabilized DProline-LProline Induced b-Hairpin Peptide of Defensin Segment Increases its Anti-Candida Albicans Ability” Zhao, B.; Yang, D.; Wong, J. H.; Wang, J.; Yin, C.; Zhu, Y.; Fan, S.; Ng, T. B.*; Xia, J*.; Li, Z.* Chembiochem, 2016, 17, 1416 – 1420. (Link) |
| 27 | “Affinity-guided protein conjugation: the trilogy of covalent protein labeling, assembly and inhibition” Yu, Y.; Xia, J.* Sci. China Chem. 2016, 59, 1-8 (Invited review) (Link) |
| 28 | “PDZ-reactive peptide activates ephrin-B reverse signaling and inhibits neuronal chemotaxis” Yu, Y.; Liu, M.; Ng, T. T.; Huang, F.; Nie, Y.; Wang, R.; Yao, Z-P.; Li, Z.; Xia, J.* ACS Chem. Biol. 2016, 11, 149-158. (Link) |
| 29 | “Site selective Azo coupling for peptide cyclization and affinity labeling of an SH3 protein.” Huang, F.; Nie, Y.; Ye, F.; Zhang, M.; Xia, J.* Bioconjugate Chem. 2015, 26, 1613-1622. |
| 30 | “Antiviral activities of whey proteins” Ng, T. B.; Cheung, R. C.; Wong, J. H.; Wang, Y.; Ip, D. T.; Wan, D. C.; Xia, J. Appl. Microbiol. Biotechnol. 2015, 99, 6997-7008. (Link) |