Division of Gastroenterology & Hepatology

Head of Division	Prof. Vincent WS Wong, Professor
Academic Staff and Clinical Staff	Prof. Joseph JY Sung, Mok Hing Yiu Professor of Medicine Prof. Francis KL Chan, Professor of Medicine and Dean Prof. Henry LY Chan, Professor Prof. Siew-Chien Ng, Professor Prof. Grace LH Wong, Professor Prof. Justin CY Wu, Professor Prof. Jun Yu, Professor Prof. Sunny H Wong, Associate Professor Prof. Joyce WY Mak, Assistant Professor Prof. Tao Zuo, Research Assistant Professor
Nursing Staff	Angel ML Chim Jessica YL Ching Thomas YT Lam
Technicians/Research Staff	Annie ON Chan Carmen KM Chan Hoi-Yun Chan Shuk-Yi Chan Yawen Chan Pui-Kuan Cheong Ching-Han Choi Eagle SH Chu Fan Fang Ka-Man Kee Katherine YY Kwan Camey WM Lai Tina KT Lau Jiang Lei Hor-Yan Li Xiaoxing Li Qiaoyi Liang Geicho Nakatsu Jiayun Shen Wing-Yan Tang Pete CH Tse Yee-Kit Tse

Facilities

Research Interests

Elucidation of the genetic and epigenetic basis of major gastrointestinal (GI) cancers (i.e. gastric, colorectal and liver cancers) and functional validation of key molecular abnormalities
Molecular characterization of fecal microbiota in nonalcoholic steatohepatitis and colorectal cancer
Identification and large-cohort validation of new diagnostic and prognostic biomarkers for GI cancers
Identification of novel therapeutic targets and development of new molecular therapies for GI cancers
Clinical trials for viral hepatitis B and C treatment
Development of non-invasive tests for diagnosis and prognostication of liver diseases
Study of ketamine-induced liver injury
Development of novel endoscopic techniques for GI cancer screening and treatment
Epidemiological and epigenomics studies of inflammatory bowel diseases
Evaluation of the functional role of autophagy in digestive diseases
Biomarkers of functional gastrointestinal disorders

Selected Publications

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 2018;390:2769-2778.

Kyaw MH, Otani K, Ching JYL, Higashimori A, Kee KM, Watanabe T, Tse YK, Lee V, Tanigawa T, Cheong PK, Suen BY, Fujiwara Y, Lam K, Arakawa T, Chan FKL. Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding. Gastroenterology 2018;155:1090-1097.

Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH. Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer. Gastroenterology 2018;155:383-390.

Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Lam TY, Yu AC, Wang X, Chen Z, Wong MC, Ng SC, Chan MTV, Chan PKS, Chan FKL, Sung JJ, Yu J. Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes. Gastroenterology 2018;155:529-541.

Wong GL, Chan HL, Tse YK, Yip TC, Lam KL, Lui GC, Wong VW. Normal on-treatment ALT during antiviral treatment is associated with a lower risk of hepatic events in patients with chronic hepatitis B. J Hepatol 2018;69:793-802.

Chan FKL, Ching JYL, Tse YK, Lam K, Wong GLH, Ng SC, Lee V, Au KWL, Cheong PK, Suen BY, Chan H, Kee KM, Lo A, Wong VWS, Wu JCY, Kyaw MH. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 2017;389:2375-2382.

Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J. Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice. Gastroenterology 2017;153:1621-1633.

Chan FK, Kyaw M, Tanigawa T, Higuchi K, Fujimoto K, Cheong PK, Lee V, Kinoshita Y, Naito Y, Watanabe T, Ching JY, Lam K, Lo A, Chan H, Lui R, Tang RS, Sakata Y, Tse YK, Takeuchi T, Handa O, Nebiki H, Wu JC, Abe T, Mishiro T, Ng SC, Arakawa T. Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin. Gastroenterology 2017;152:105-110.

Chan HL, Fung S, Seto WK, Chuang WL, Chen CY, Kim HJ, Hui AJ, Janssen HL, Chowdhury A, Tsang TY, Mehta R, Gane E, Flaherty JF, Massetto B, Gaggar A, Kitrinos KM, Lin L, Subramanian GM, McHutchison JG, Lim YS, Acharya SK, Agarwal K; GS-US-320-0110 Investigators. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol 2016;1:185-195.

Kwok R, Choi KC, Wong GL, Zhang Y, Chan HL, Luk AO, Shu SS, Chan AW, Yeung MW, Chan JC, Kong AP, Wong VW. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study. Gut 2016;65:1359-68.