Students

Name: Tian Qi

Post: Full-time Ph.D

Enrolled: August 2004 - 2007

Origin: Mainland China, Shandong, Qingdao

Supervisor: Prof. Charles D. Gomersall, Prof. Tony Gin

Title of Thesis:

Antibiotic adsorption by haemofilters

Outline of the Thesis:

Sepsis-induced acute renal failure is common in critically ill patients. Outside of North America these patients usually receive continuous renal replacement therapy (CRRT) which utilizes high flux haemofilter membranes. Thus it is common for these patients to be concurrently receiving antibiotics and CRRT. However, information about the various filter's adsorptive capacity for most drugs is lacking. Thus we developed one in-vitro model to examine adsorption of antibiotics onto haemofilters. We also established high-performance liquid chromatography (HPLC) to assay levofloxacin and vancomycin. Fluorescence polarization immunoassay (FPIA) was used to assay amikacin. Oseltamivir carboxylate and telavancin was determined using HPLC/MS methods.

Our main recent findings included: (1) low absolute adsorption of levofloxacin and oseltamivir carboxylate by haemofilters at clinically relevant concentrations; (2) the adsorption of levofloxacin is dependent on initial concentration and is reversible; (3) the adsorption of oseltamivir carboxylate is dependent on initial concentration, but not on membrane-material; (4) sieving coefficient (SC) of oseltamivir carboxylate is very near to 1.0 (1- protein binding of oseltamivir carboxylate).

In conclusion, the effect of antibiotic adsorption by haemofilters on pharmacokinetics and pharmacodynamics and the relevantly influencing factors might be considered in ICU work.

Publications arising from his research work:

(A) Scientific Papers:

1. Tian Q, Gomersall CD, Wong A, Leung P, Choi G, Joynt GM, Tan P, Lipman J. Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters. Int J Antimicrob Agents 2006; 28:147-50.
   
   
2. Gruber PC, Tian Q, Gomersall CD, Joynt GM, Choi G. An in vitro study of elimination of oseltamivir carboxylate by haemofiltration. Int J Antimicrob Agents 2007; 30:95-97.
   
   
3. Tian Q, Gomersall CD, Leung P, Choi G, Joynt GM, Tan P, Wong A. The adsorption of vancomycin by polyacrylonitrile, polyamide and polysulfone hemofilters. Artif Organs 2008; 32:81-4
   
   
4. Tian Q, Gomersall CD, IP M, Tan PE, Joynt GM, Choi G. Adsorption of amikacin: a significant mechanism of elimination by haemofiltration. Antimicrob Agents Chemother 2008; 52:1009-13.
   
   

(B) Conference Abstracts:

5. Tian Q, Gomersall CD, Leung P, Choi G, Joynt GM, Tan P, Wong A. In vitro adsorption of vancomycin by three types of hemofilters. The Society of Critical Care Medicine (SCCM) 36th Critical Care Congress 2007, Orlando, FL, USA. 17-21 Feburuary, 2007 Crit Care Med 2006; 34: A97.
   
   
6. Tian Q, Gomersall CD, Leung P, Choi G, Joynt GM, Tan P, Wong A. The adsorption of vancomycin by polyacrylonitrile/AN69 and polyamide haemofilters. The 14th Congress of Asia Pacific Association of Critical Care Medicine (APACCM 2006), Beijing, China. 26-29 August, 2006