中大職務
醫學院助理院長 (內地事務)
內科及藥物治療學系教授
消化疾病研究所管理委員會委員
消化疾病研究實驗室主任
消化疾病研究國家重點實驗室副主任
專業範疇
- 胃腸道腫瘤發生機制
- 脂肪性肝病
- 腸道微生態和腫瘤
教育及資歷
MB, MM (Heibei Med); MD, PhD (Tongji Med).
專注研究
- 消化道腫瘤發生過程中的基因組和表觀遺傳學組異常改變
- 腸道微生態，細菌和宿主細胞的相互作用和腫瘤的發生和發展
- 非酒精性脂肪肝病和其相關肝癌的發病機制和治療靶點
- 消化道腫瘤診斷和治療標誌物
更多資訊
獎項及榮譽
- 何梁何利基金科學與技術進步獎, 2018
- 美國胃腸病學會腫瘤研究導師獎, 2017
- 藥明康得生命化學研究獎, 2017
- 國家自然科學獎二等獎, 2016
- 國家創新團隊獎, 2016
- 香港裘槎卓越科研獎等, 2016
- 香港中文大學醫學院傑出研究員, 2015
- 教育部自然科學獎一等獎, 2014 & 2010
- 國家科技進步獎二等獎, 2012
- 教育部科技進步獎一等獎, 2012
- 香港中文大學研究優勝獎, 2009
專業服務
- 中國抗癌協會微生態與腫瘤學會副主任
- 美國胃腸病學會微生態和代謝常務理事
- 國際腫瘤微生態學會（英國）理事
美國胃腸病學會腫瘤常務理事
教育部長江學者講座教授
香港科學家協會副主席
Oncogene 副編輯； Gut、Scientific Reports 及 JGH 編輯
香港免疫學會主席, 2017-2018
香港流式細胞學會主席, 2015-2016
部分論文 (只有英文版本)
- Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019 Jul;71(1):163-174.
- Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J. Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut. 2019 Apr;68(4):654-662.
- Liang JQ, Teoh N, Xu L, Pok S, Li X, Chu ESH, Chiu J, Dong L, Arfianti E, Haigh WG, Yeh MM, Ioannou GN, Sung JJY, Farrell G, Yu J. Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling. Nat Commun. 2018 Oct 26;9(1):4490.
- Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Yuen-Tung Lam T, Chi-Shing Yu A, Wang X, Chen Z, Chi-Sang Wong M, Ng SC, Chan MTV, Chan PKS, Leung Chan FK, Jao-Yiu Sung J, Yu J. Alterations in Enteric Virome Associate With Colorectal Cancer and Survival Outcomes. Gastroenterology. 2018 Aug;155(2):529-541.e5.
- Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018 Jun;67(6):1024-1032.
- Sun W, Zhang Y, Wong KC, Liu K, Yang Y, Wu B, Tong JH, Chan AW, Chan HL, Yu J. Increased expression of GATA Zinc Finger Domain Containing 1 via gene amplification promotes liver cancer by directly inducing PRL3. Hepatology. 2018 Jun;67(6):2302-2319.
- Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437).
- Tsoi H, Chu ES, Zhang X, Sheng J, Nakatsu D, Ng SC, Chan AW, Chan FK, Sung JJ, Yu J. Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017 May;152(6):1419-1433.e5.
- Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, Chen H, Go MY, Wu JL, Cheng KW, Ng SS, Sung JJ, Cai Z, Yu J. SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations, and Xenograft Tumor Progression in Mice, via Intracellular Synthesis of Aspartate. Gastroenterology. 2016 Nov;151(5):945-960.
- Zhang J, Tsoi H, Li X, Wang H, Gao J, Wang K, Go MY, Ng SC, Chan FK, Sung JJ, Yu J. Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis. Gut. 2016 Sep;65(9):1482-93.